کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9455 630 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals
چکیده انگلیسی

Here we report the synthesis of uniform silica coated hexagonal-phase NaYF4 nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF4 nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF4 upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 29, Issue 30, October 2008, Pages 4122–4128
نویسندگان
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