An anti-staphylococcal acylphloroglucinol from Hypericum foliosum

Bioassay-guided isolation of a hexane extract of Hypericum foliosum (Guttiferae) led to the characterisation of the new acylphloroglucinol (1) as the major anti-staphylococcal principle. Minimum inhibitory concentration values ranged from 16-32 μg/ml against methicillin and multidrug-resistant Staphylococcus aureus strains.