کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9573198 | 1388887 | 2005 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of the modal hypothesis of Ca2+-dependent inactivation of L-type Ca2+ channels
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
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چکیده انگلیسی
A kinetic model of Ca2+-dependent inactivation (CDI) of L-type Ca2+ channels was developed. The model is based on the hypothesis that postulates the existence of four short-lived modes with lifetimes of a few hundreds of milliseconds. Our findings suggest that the transitions between the modes is primarily determined by the binding of Ca2+ to two intracellular allosteric sites located in different motifs of the CI region, which have greatly differing binding rates for Ca2+ (different kon). The slow-binding site is controlled by local Ca2+ near a single open channel that is consistent with the “domain” CDI model, and Ca2+ binding to the fast-binding site(s) depends on Ca2+ arising from distant sources that is consistent with the “shell” CDI model. The model helps to explain numerous experimental findings that are poorly understood so far.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 117, Issue 2, 1 September 2005, Pages 173-190
Journal: Biophysical Chemistry - Volume 117, Issue 2, 1 September 2005, Pages 173-190
نویسندگان
Nick I. Markevich, Oleg Y. Pimenov, Yury M. Kokoz,