Metal nitrates catalysed O-glucosylation using acetyl glucal in organic solvents and ionic liquids: A comparative investigation

The screening of metal nitrates revealed the ability of Bi(NO3)3·5H2O and Fe(NO3)3·9H2O as catalyst for the Ferrier O-glucosylation using 3,4,6-tri-O-acetyl-d-glucal. The Bi(NO3)3·5H2O-mediated O-glucosylation show substantial solvent dependency and enhanced reaction rate in [bmim][PF6] than in the conventional organic solvents. Apart from the ambient quality, eco-friendly nature and catalyst economy, the Bi(NO3)3·5H2O/[bmim][PF6] method offers good yields and high anomeric selectivity, reduced catalyst concentration, reduced reaction time and recyclability of reaction medium.