کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9645961 546060 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of GABAA receptor modulating neuroactive steroids in patients with social phobia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Involvement of GABAA receptor modulating neuroactive steroids in patients with social phobia
چکیده انگلیسی
Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEA-S), neurosteroids synthesized in the brain, are weak gamma-aminobutyric acid (GABA) A receptor allosteric antagonists that may be involved in anxiety disorders. In the present study we measured the levels of DHEA, DHEA-S, pregnenolone and cortisol in platelets of untreated patients (n = 26) diagnosed with social phobia (SP) compared with sex- and age-matched healthy controls (n = 21). No significant differences in neurosteroids were observed in the platelets of untreated SP patients compared with healthy controls. The findings may reflect an absence of involvement of the GABAA modulators DHEA, DHEA-S and pregnenolone in SP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 137, Issues 1–2, 15 November 2005, Pages 131-136
نویسندگان
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