کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9645988 | 546070 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cholecystokinin (CCK) and the CCKA receptor gene polymorphism, and smoking behavior
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We analyzed genetic variants of the promoter region of the cholecystokinin (CCK; which modulates the release of dopamine) gene, and intron 1 and exon 5 of the CCKA receptor gene, and performed association analyses of nicotine dependence using an allele-specific amplification (ASA) method and PCR-RFLP methods. There was a significant difference between the current smoking and nonsmoking groups in the allele frequency of the CCK-45C/T polymorphism. However, there was no significant difference in the CCKA PstI polymorphism, and the HincII polymorphism was not detected in our study. Our data suggest that polymorphisms of the CCK gene may be one of the risk factors for smoking behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 133, Issues 2â3, 28 February 2005, Pages 123-128
Journal: Psychiatry Research - Volume 133, Issues 2â3, 28 February 2005, Pages 123-128
نویسندگان
Takahiro Takimoto, Hayato Terayama, Chikako Waga, Takashi Okayama, Kazutaka Ikeda, Isao Fukunishi, Kazuhiko Iwahashi,