کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9727913 | 1480213 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Helix-coil transition in closed circular DNA
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A simplified model for the closed circular DNA (ccDNA) is proposed to describe some specific features of the helix-coil transition in such molecules. The Hamiltonian of ccDNA is related to the one introduced earlier for the open chain DNA (ocDNA). The basic assumption is that the reduced energy of the hydrogen bond is not constant through the transition process but depends effectively on the fraction of already broken bonds. A transformation formula is obtained which relates the temperature of ccDNA at a given degree of helicity during the transition to the temperature of the corresponding open chain at the same degree of helicity. The formula provides a simple method to calculate the melting curve for the ccDNA from the experimental melting curve of the ocDNA with the same nucleotide sequence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 348, 15 March 2005, Pages 327-338
Journal: Physica A: Statistical Mechanics and its Applications - Volume 348, 15 March 2005, Pages 327-338
نویسندگان
Vladimir F. Morozov, Eugene Sh. Mamasakhlisov, Arsen V. Grigoryan, Artem V. Badasyan, Shura Hayryan, Chin-Kun Hu,