کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
974726 932995 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Local and global responses in complex gene regulation networks
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
پیش نمایش صفحه اول مقاله
Local and global responses in complex gene regulation networks
چکیده انگلیسی
Here we address, on a data analysis perspective, the discrimination between local and global scale regulations, this goal was achieved by means of the examination of two biological systems: innate immune response in macrophages and oscillating growth dynamics in yeast. Our aim was to reconcile the 'hard-wired' local view of gene regulation with a global continuous and scalable one borrowed from statistical physics. This reconciliation is based on the network paradigm in which the local 'hard-wired' activities correspond to the activation of specific crucial nodes in the regulation network, while the scalable continuous responses can be equated to the collective oscillations of the network after a perturbation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 388, Issue 8, 15 April 2009, Pages 1738-1746
نویسندگان
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