کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9753203 1494197 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective photo-reduction of N-nitroamines combined with micellar electrokinetic chromatography and laser fluorimetric detection
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Selective photo-reduction of N-nitroamines combined with micellar electrokinetic chromatography and laser fluorimetric detection
چکیده انگلیسی
N-nitroso compounds (NOC) are potent carcinogens. Reliable methods for the analysis of volatile carcinogenic NOC are well established; however selective and sensitive methods for routine analysis of thermally unstable, ionic or non-volatile NOC are still needed. For this purpose, a method based on micellar electrokinetic chromatography (MEKC) with laser induced fluorescence (LIF) detection is described for the simultaneous determination of a broad range of N-nitroso compounds. In this procedure, the nitroso group is photolytically cleaved from the NOC to yield the corresponding amine. The amines are then derivatized with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl), identified and quantified using MEKC-LIF. For the standard mixture of NOC, this method has good sensitivity and a large dynamic range. The detection limit provided by the method is 9 ppb for N-nitrosopyrrolidine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 826, Issues 1–2, 5 November 2005, Pages 160-168
نویسندگان
, ,