کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9753336 1494200 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Huperzine A-human serum albumin association: Chromatographic and thermodynamic approach
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Huperzine A-human serum albumin association: Chromatographic and thermodynamic approach
چکیده انگلیسی
The synthesis of six new huperzine analogues was reported. Each product presents an amidification of the free amine on huperzine A. The synthesis strategy of these new huperzine A derivatives is based on a condensation with an acyl anhydride. The binding on HSA of two molecule series (huperzine and benzodiazepine, respectively) was investigated with high performance liquid affinity chromatography (HPLAC) using an HSA column. A thermodynamic approach showed that binding huperzine A on HSA involved hydrophobic and Van der Waals interactions. A comparative thermodynamic study with benzodiazepine molecules was carried out to determine the potential binding site of huperzine derivatives on HSA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 820, Issue 2, 25 June 2005, Pages 283-288
نویسندگان
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