کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9818183 1518777 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of trace elements in the human substantia nigra
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سطوح، پوشش‌ها و فیلم‌ها
پیش نمایش صفحه اول مقاله
Determination of trace elements in the human substantia nigra
چکیده انگلیسی
For the first time, we have differentially investigated the intra- and extraneuronal elemental concentrations (especially iron) of the human substantia nigra pars compacta versus pars reticulata with detection limits in the range of 50 μmol/l. Thus, we could compare the neuronal iron concentration in human brain sections of healthy and parkinsonian brain tissue. Clear differences in the iron concentration and distribution could be disclosed. Additionally, we could show in situ that the increased intraneuronal iron content is linked to neuromelanin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms - Volume 231, Issues 1–4, April 2005, Pages 224-228
نویسندگان
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