کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9830307 1524506 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Using magnetic fields to control convection during protein crystallization-analysis and validation studies
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
پیش نمایش صفحه اول مقاله
Using magnetic fields to control convection during protein crystallization-analysis and validation studies
چکیده انگلیسی
The effect of convection during the crystallization of proteins is not very well understood. In a gravitational field, convection is caused by crystal sedimentation and by solutal buoyancy induced flow and these can lead to crystal imperfections. While crystallization in microgravity can approach diffusion-limited growth conditions (no convection), terrestrially strong magnetic fields can be used to control fluid flow and sedimentation effects. In this work, we develop the analysis for magnetic flow control and test the predictions using analog experiments. Specifically, experiments on solutal convection in a paramagnetic fluid were conducted in a strong magnetic field gradient using a dilute solution of manganese chloride. The observed flows indicate that the magnetic field can completely counter the settling effects of gravity locally and are consistent with the theoretical predictions presented. This phenomenon suggests that magnetic fields may be useful in mimicking the microgravity environment of space for some crystal growth and biological applications where fluid convection is undesirable.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crystal Growth - Volume 274, Issues 1–2, 15 January 2005, Pages 297-306
نویسندگان
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