Relationship between plasma lipid concentrations and HDL subclasses

With the increase of plasma TG, TC, LDL-C or the decrease of plasma HDL-C concentrations, there was a general shift toward smaller-sized HDL, which, in turn, indicates that reverse cholesterol transport might be weakened and HDL maturation might be abnormal. Plasma TG concentration is a more important factor than TC concentration on the changes of HDL subclass distribution. Moreover, when TG is normal and HDL-C decreased, large-size HDL particles tended to decrease.