کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9892243 | 1541106 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The aim of this study was to analyze the cardiovascular effects of chronic stanozolol administration in male rats. The rats were randomly assigned to one of three groups: (1) control (n = 12), (2) chronic treatment with low dose of stanozolol (LD, n = 18, 5 mg/kg week) and; (3) treatment with high dose of stanozolol (HD, n = 28, 20 mg/kg week). Mean arterial pressure (MAP) was higher in both HD (128 ± 2.2 mmHg) and LD (126 ± 2.5 mmHg) than control (116 ± 2 mmHg). The LD group showed an increase in cardiac output (control 121 ± 2.5, LD 154 ± 5.9 ml/min), whereas in the HD group total peripheral resistance increased (control 1.03 ± 0.07, HD 1.26 ± 0.07 mmHg/ml/min). Acute sympathetic blockade caused a similar decrease in MAP in all groups. In conscious rats, the baroreflex index for bradycardia (control â3.7 ± 0.4, LD â2.0 ± 0.1 beat/mmHg) and tachycardia (control â3.6 ± 0.3, LD â4.7 ± 0.2 beat/mmHg) responses changed only in the LD group. Cardiac hypertrophy was observed in both treated groups (P < 0.05). In conclusion, hypertension with differential hemodynamic changes and alterations in the reflex control in heart rate is seen at different stanozolol doses, which may be important variables in the cardiovascular effects of anabolic steroids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 93, Issue 1, January 2005, Pages 43-48
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 93, Issue 1, January 2005, Pages 43-48
نویسندگان
Abram Beutel, Cássia Toledo Bergamaschi, Ruy Ribeiro Campos,