کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9894066 1542259 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemical approaches to the lysophospholipid receptors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Chemical approaches to the lysophospholipid receptors
چکیده انگلیسی
Both ligand-based and GPCR privileged scaffold chemical tools have recently emerged to provide new insights into the function and physiology of the GPCR lysophospholipid receptors both in vitro and in vivo. Both rational, design-based approaches as well as hybrid approaches where high throughput screening has been coupled to an understanding of critical molecular interactions have been productive in advancing understanding of physiology and potential therapeutics in this field. It is now feasible to identify reasonably potent and selective small molecules that provide chemical proof-of-concept in vivo directly from high throughput screening. These developments, coupled with the availability of receptor knock-out mice, presage rapid progress in the field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins & Other Lipid Mediators - Volume 77, Issues 1–4, September 2005, Pages 179-184
نویسندگان
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