کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9894357 | 1542454 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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![عکس صفحه اول مقاله: Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima Cloning of novel bombesin precursor cDNAs from skin of Bombina maxima](/preview/png/9894357.png)
چکیده انگلیسی
Amphibian skin is a rich resource of bioactive peptides like proline-rich bombesin from frog Bombina maxima. A novel cDNA clone encoding a precursor protein that comprises proline-rich bombesin and a novel peptide, designated as bombestatin, was isolated from a skin cDNA library of B. maxima. The predicted primary structure of the novel peptide is WEVLLNVALIRLELLSCRSSKDQDQKESCGMHSW, in which two cysteines form a disulfide bond. A BLAST search of databases did not detect sequences with significant similarity. Bombestatin possesses dose-dependent contractile activity on rat stomach strips. The differences between cDNAs encoding PR-bombesin plus bombestatin and PR-bombesin alone are due to fragment insertions located in 3â²-coding region and 3â²-untranslational region, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 132, Issues 1â3, 15 December 2005, Pages 102-106
Journal: Regulatory Peptides - Volume 132, Issues 1â3, 15 December 2005, Pages 102-106
نویسندگان
Ji-Hong Shen, Shu-Bai Liu, Ying-Xia Zhang, Yang Jin, Wen-Hui Lee, Yun Zhang,