کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9901408 | 1545419 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Baclofen-loaded microspheres in gel suspensions for intrathecal drug delivery: In vitro and in vivo evaluation
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کلمات کلیدی
PLGALC/MSMSCMCLOQBaclofen - باکلوفنBurst effect - تأثیر برانگیختنIntrathecal administration - تزریق داخل رحمیLod - لودCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیlimit of quantification - محدودیت اندازه گیریlimit of detection - محدودیت تشخیصMicrospheres - میکروسپرسPLGA microsphere - میکروسپور PLGAPoly (lactide-co-glycolide) - پلی (لاکتید گلیکولید)Polymer gel - ژل پلیمرcarboxymethylcellulose - کربوکسی متیل سلولزliquid chromatography tandem mass spectrometry - کروماتوگرافی مایع اسپکترومتری دو طرفه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
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چکیده انگلیسی
Baclofen was encapsulated in poly(lactide-co-glycolide) (PLGA) microspheres which were then dispersed in chitosan thermosensitive gels, Pluronic® PF-127 gels, carboxymethylcellulose solutions or Ringer lactate solution. The release rate was assessed in vitro using continuous flow cells and in vivo after intrathecal injection in goats: baclofen was quantified in cerebrospinal fluid (CSF) and plasma, and the associated pharmacological effect was evaluated. The results showed that the burst effect was reduced by at least a factor of 2 in vitro, after microsphere dispersion in viscous media. In vivo, PF-127 gel was found to be the best vehicle to reduce the burst effect by a factor of 10 in CSF, and by a factor of 2 in plasma. The toxic effect of baclofen due to the burst effect was reduced by the dispersion in PF127 gels. Therapeutic levels of baclofen in CSF were maintained during at least 1 month.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 61, Issue 3, October 2005, Pages 171-180
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 61, Issue 3, October 2005, Pages 171-180
نویسندگان
Frederic Lagarce, Nathalie Faisant, Jean-Claude Desfontis, Laurent Marescaux, Freddy Gautier, Joel Richard, Philippe Menei, Jean-Pierre Benoit,