کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9912409 1549780 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells
چکیده انگلیسی
It has been suggested that baicalein, a flavonoid obtained from the Scutellaria root, exerts a protective role on neurons against several neuronal insults. However, the protective mechanisms underlying this protective effect remain largely unknown. Our results indicate that baicalein protects SH-SY5Y cells, a dopaminergic neuronal cell line, from 6-hydroxydopamine (6-OHDA)-induced damage by the attenuation of reactive oxygen species (ROS). In order to determine the effects of baicalein on mitochondrial events, mitochondrial membrane potentials (ΔΨm) and caspase cascades downstream of mitochondria were assessed. Baicalein inhibited the collapse of ΔΨm, suggesting that baicalein reduces the mitochondrial dysfunction associated with 6-OHDA treatment. Baicalein also inhibited caspase-9 and caspase-3 activation, which can be triggered by mitochondrial malfunctions. Furthermore, baicalein induced a significant reduction in the level of phospho-JNK, which is known as an apoptotic mediator in 6-OHDA-induced neuronal cell death. Our results indicate that baicalein protects neurons from the deleterious effects of 6-OHDA via the attenuation of oxidative stress, mitochondrial dysfunction, caspase activity, and JNK activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cell Biology - Volume 84, Issue 11, 14 November 2005, Pages 897-905
نویسندگان
, , , , , , , ,