کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9917623 | 1556304 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique
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کلمات کلیدی
PMSGelucire®XRPDGBMDSCTGAPVPSDSAmorphous - آمورفDiffuse Reflectance Infrared Fourier Transform Spectroscopy - اسپکتروسکوپ تبدیل فوریه مادون قرمز Reflection DiffusionDRIFTS - جادوهاSpray drying - خشک کردن اسپریSilicon dioxide - سیلیکون دی اکسیدphysical mixtures - مخلوط های فیزیکیSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیScanning electron microscopy - میکروسکوپ الکترونی روبشیX-ray powder diffraction - پراش پودر اشعه ایکسSolid dispersions - پراکندگی جامدpolyvinylpyrrolidone - پلی وینیل پیرولیدونPEG - پلیاتیلن گلیکول Differential scanning calorimetry - کالریمتری روبشی افتراقیglibenclamide - گلی بن کلامیدPolyethylene glycols - گلیکول پلی اتیلن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Solid dispersions (SDs) of glibenclamide (GBM); a poorly water-soluble drug and polyglycolized glycerides (Gelucire®) with the aid of silicon dioxide (Aerosil® 200); as an adsorbent, were prepared by spray drying technique. SDs and spray dried GBM in comparison with pure GBM and corresponding physical mixtures (PMs) were initially characterized and then subjected to ageing study up to 3 months. Initial characterization of SDs and spray dried GBM by DSC and XRPD showed that GBM was present in its amorphous form (AGBM). Improvement in the solubility and dissolution rate was observed for all samples. DRIFT spectroscopy revealed presence of hydrogen bonding in SDs. During ageing study, almost no decrease of in vitro drug dissolution was observed, over the period of 3 months as compare with freshly prepared SDs. Slight crystallinity in SDs was observed in the DSC and XRPD studies during ageing. Moreover in vivo study in Swiss Albino mice also justified the improvement in the therapeutic efficacy of amorphous GBM in SDs over pure GBM. Thus, present study demonstrated the high potential of spray drying technique for obtaining stable free flowing SDs of poorly water-soluble drugs using polyglycolized glycerides carriers with the aid of silicon dioxide as an adsorbent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 26, Issue 2, October 2005, Pages 219-230
Journal: European Journal of Pharmaceutical Sciences - Volume 26, Issue 2, October 2005, Pages 219-230
نویسندگان
Bhaskar Chauhan, Shyam Shimpi, Anant Paradkar,