Genetics of nicotine and tobacco dependency

Animal studies have shown that variations in the structure of the nicotinergic acetylcholine receptor might interfere with the development of nicotine dependence. Other possible candidate genes for receptors in the serotonergic, adrenergic and dopaminergic system are being examined as potential contributors to the development of nicotine or tobacco dependence. Furthermore, reduced metabolism of nicotine into cotinine may also reduce risk for nicotine dependence. Although current research findings cannot fully explain how nicotine or tobacco dependence develops, it has advanced understanding of dependence disorders.