کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9933609 | 1568467 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus
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کلمات کلیدی
LPSGAPDHPPINS2Influenza - آنفلوانزا Fetus - جنین minimal essential medium - حداقل وسایل ضروریBrain development - رشد مغز lipopolysaccharide - لیپوپلی ساکاریدMEM - مامانPrepulse inhibition - مهار پیش قاعدگیneuraminidase - نورآمینیدازmatrix protein - پروتئین ماتریکسNuclear protein - پروتئین هسته ایGlyceraldehyde phosphate dehydrogenase - گلیسرالیدید فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus](/preview/png/9933609.png)
چکیده انگلیسی
Epidemiological studies have shown that maternal infection can increase the risk for mental illness in the offspring. In a mouse model of maternal respiratory infection with influenza virus, the adult offspring display striking behavioral, pharmacological and histological abnormalities. Although influenza primarily infects the respiratory system, there are reports of viral mRNA and protein in the fetus of infected pregnant animals. To determine the extent of viral spread following maternal respiratory infection, we used RT-PCR to assay various maternal and fetal tissues for influenza A mRNAs coding for neuraminidase, non-structural protein 2, nuclear protein and matrix protein. While infected maternal lungs exhibit uniformly very strong signals, placentae are only rarely positive, and viral RNAs are not detectable in fetal brains from infected mothers. Thus, the effects of maternal infection on fetal brain development are likely to be indirect, probably involving the maternal inflammatory response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 23, Issues 2â3, AprilâMay 2005, Pages 299-305
Journal: International Journal of Developmental Neuroscience - Volume 23, Issues 2â3, AprilâMay 2005, Pages 299-305
نویسندگان
Limin Shi, Nora Tu, Paul H. Patterson,