Effect of BQ-123, an Endothelin Antagonist, on Renal Hemodynamics, Tubular Function, Vasoactive Hormones, and Blood Pressure in Healthy Humans: A Dose Response Study

Infusion of an endothelin A antagonist resulted in an increase in renal sodium excretion despite a stimulation of the renin-angiotensin system and a decrease in diastolic BP.