Antagonism of the Renin-Angiotensin System Can Counteract Cardiac Angiogenic Vascular Endothelial Growth Factor Gene Therapy and Myocardial Angiogenesis in the Normal Heart

Enalapril and candesartan both specifically inhibit phVEGF-A165 induced myocardial angiogenesis in the normal heart. The mechanism of inhibition is a combination of inhibition of cardiac hVEGF-A expression and of decreased endogenous expression of the mVEGF ligand and receptor system.