کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9943339 | 1573501 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute Tumor Necrosis Factor-α-Induced Liver Injury in the Absence of Tumor Necrosis Factor Receptor-Associated Factor 1 Gene Expression
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Pulmonary and serum levels of tumor necrosis factor-α (TNF-α), are elevated in many lung diseases, causing local inflammation, fever, and multiorgan, including hepatic, dysfunction. Cellular responses to TNF-α are determined by recruitment of specific proteins to intracellular receptor signaling complexes. One of these proteins, TNF receptor-associated factor 1 (TRAF1), is highly regulated in pulmonary cells. To determine the effect of reduced pulmonary TRAF1 expression, TRAF1-null (â/â) and control, BALB/c (wild-type), mice were treated intratracheally, intraperitoneally, or intravenously, with TNF-α. Despite relatively mild lung injury, intratracheal TNF-α-treated TRAF1â/â mice exhibited marked liver injury with an approximate fivefold increase in serum liver enzyme levels as compared to wild-type mice. In addition, serum TNF-α levels were strikingly elevated in TRAF1â/â mice. Pretreatment with neutralizing anti-TNFRI antibody significantly reduced liver injury and serum TNF-α. Cells isolated by bronchoalveolar lavage from intratracheally treated TRAF1â/â mice produced more TNF-α than cells from treated wild-type mice, suggesting that lung cells contributed to elevated serum TNF-α. These studies suggest that TRAF1 provides negative feedback for TNF-α synthesis and limits TNFRI-mediated systemic effects of TNF-α originating in the lung.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Pathology - Volume 166, Issue 6, June 2005, Pages 1637-1645
Journal: The American Journal of Pathology - Volume 166, Issue 6, June 2005, Pages 1637-1645
نویسندگان
Gloria S. Pryhuber, Heidie L. Huyck, Jason M. Roper, Judith Cornejo, Michael A. O'Reilly, Robert H. Pierce, Erdyni N. Tsitsikov,