کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9954293 | 1543151 | 2018 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Experimental Models for Studying Food Allergy
ترجمه فارسی عنوان
مدل های تجربی برای مطالعه آلرژی غذایی
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کلمات کلیدی
TregLCTLong chain triglyceridesFCER1AEPITFcεRITSLPT helperHSCGM-CSFPBMCIgEMCTWASPAnaphylaxis - آنافیلاکسی یا بیشدفاعی epicutaneous immunotherapy - ایمونوتراپی epicutangeoral immunotherapy - ایمونوتراپی دهانimmunoglobulin - ایمونوگلوبولینinterleukin - اینترلوکینmedium chain triglycerides - تری گلیسیرید زنجیره متوسطallergen sensitization - حساسیت به آلرژنOIT - سازمان بین المللی کارRegulatory T cell - سلول T تنظیم کنندهHematopoietic stem cell - سلول بنیادی هماتوپوئیتPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیgranulocyte-macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factorThymic stromal lymphopoietin - لنفوپیتین استروما تیمیکmouse mast cell protease - پروتئاز ماست سلولی ماوسWiskott–Aldrich syndrome protein - پروتئین سندرم Wiskott-Aldrichallergen challenge - چالش آلرژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی
Immunoglobulin E-mediated food allergy is rapidly developing into a global health problem. Publicly available therapeutic intervention strategies are currently restricted to allergen avoidance and emergency treatments. To gain a better understanding of the disease pathophysiology so that new therapies can be developed, major research efforts have been put into studying food allergy in mice. Animal models should reflect the human pathology as closely as possible to allow for a rapid translation of basic science observations to the bedside. In this regard, experimental models of food allergy provide significant challenges for research because of discrepancies between the presentation of disease in humans and mice. The goal of this review is to give a summary of commonly used murine disease models and to discuss how they relate to the human condition. We will focus on epicutaneous sensitization models, on mouse strains that sensitize spontaneously to food as seen in humans, and on models in humanized animals. In summary, expanding the research toolbox of experimental food allergy provides an important step toward closing gaps in our understanding of the derailing immune mechanism that underlies the human disease. The availability of additional experimental models will provide exciting opportunities to discover new intervention points for the treatment of food allergies. (Cell Mol Gastroenterol Hepatol 2018;x:x)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular and Molecular Gastroenterology and Hepatology - Volume 6, Issue 3, 2018, Pages 356-369.e1
Journal: Cellular and Molecular Gastroenterology and Hepatology - Volume 6, Issue 3, 2018, Pages 356-369.e1
نویسندگان
Cynthia Kanagaratham, Benjamin F. Sallis, Edda Fiebiger,