کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9954923 | 1559727 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of the efficacy of nicotine in treatment of allergic asthma in BALB/c mice
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کلمات کلیدی
TGF-βT helper 2FBSTh2TregnAChROVAPBSTIL-4BSA - BSAAsthma - آسمbovine serum albumin - آلبومین سرم گاوAllergy - آلِرژیinflammation - التهاب( توروم) Ovalbumin - اوبلبومینInterleukin 4 - اینترلوکین 4Transforming Growth Factor Beta - تبدیل بتا فاکتور رشدfetal bovine serum - سرم جنین گاوRegulatory T cell - سلول T تنظیم کنندهBAL fluid - شیر مایعBronchoalveolar lavage fluid - مایع لارو برونکلوفلورNicotine - نیکوتین nicotinic acetylcholine receptor - گیرنده استیلکولین نیکوتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nicotine, an nAChR agonist, shows prominent anti-inflammatory properties, and some studies have illustrated its suppressive effects on inflammation. Here, we have examined whether nicotine as a medicine may have beneficial effects on the treatment of asthma in a mouse model of allergic asthma. BALB/c mice were sensitized with OVA and alum. Two weeks later, the mice received nicotine with concentrations of 1 and 10â¯mg/kg three times every other day. After 10â¯days, the mice were challenged with OVA (5%) using an ultrasonic nebulizer and died the next day. Our results showed that the administration of nicotine reduced lung-tissue inflammation, the number of eosinophils in bronchoalveolar fluid, allergen-specific IgE and IL-4 production, while it increased the TGF-β/IL-4 ratio and the number of Treg cells. Our results showed that nicotine applies its suppressive effects in a dose-dependent manner: administration of 10â¯mg/kg of nicotine showed more suppressive effects than 1â¯mg/kg. Such data suggested that nicotine might be a good candidate to be used as a medicine in the treatment of allergic asthma by decreasing allergic inflammation severity and potentiating Treg cells proliferation against the allergen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 63, October 2018, Pages 239-245
Journal: International Immunopharmacology - Volume 63, October 2018, Pages 239-245
نویسندگان
Ebrahim Mazloomi, Behrooz Ilkhanizadeh, Ahad Zare, Adel Mohammadzadeh, Nowruz Delirezh, Shahram Shahabi,