کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9959538 | 1577531 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes
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کلمات کلیدی
LDL-CPROVE IT-TIMI 22ICAMPAI-1HMG-CoAvWFtPAACSinterleukin - اینترلوکینplasminogen activator inhibitor - بازدارنده فعال کننده پلاسمینوژنcoronary artery disease - بیماری عروق کرونرThrombomodulin - ترومبومودولینacute coronary syndromes - سندرم های کرونری حادCAD - طراحی به کمک رایانه یا کَدTissue factor - عامل بافتVon Willebrand factor - عامل فون ویلبراندtissue plasminogen activator - فعال کننده بافتی پلاسمینوژنintercellular adhesion molecule - مولکول چسبندگی بین سلولیNitric oxide - نیتریک اکسیدC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی Low-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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![عکس صفحه اول مقاله: The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes](/preview/png/9959538.png)
چکیده انگلیسی
Emerging data suggest that acute presentations of coronary artery disease may involve a complex interplay between the vessel wall, inflammatory cells, and the coagulation cascade. Although a culprit thrombotic lesion may be treated effectively by antithrombotic therapy and revascularization, this will have little effect on the global processes that determine recurrent events at non-culprit sites. Thus, additional systemic treatment is required to modulate the adverse biological features that are the hallmark of acute coronary syndromes (ACS). Statins possess multiple beneficial effects that are independent of low-density-lipoprotein cholesterol (LDL-C) lowering and that have favorable effects on inflammation, the endothelium, and the coagulation cascade. In the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22 (PROVE IT-TIMI 22) trial, differences were seen based on achieved LDL-C that could be further discriminated by the achieved C-reactive protein level. Studies of non-vascular disease such as multiple sclerosis have shown that statins reduce inflammation, supporting the presence of lipid-independent effects of statins. This review focuses on the potential importance of these effects in the management of ACS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 46, Issue 8, 18 October 2005, Pages 1425-1433
Journal: Journal of the American College of Cardiology - Volume 46, Issue 8, 18 October 2005, Pages 1425-1433
نویسندگان
Kausik K. MRCP, MD, Christopher P. (FACC),