کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9990899 | 1580829 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study
ترجمه فارسی عنوان
نمره ریسک پولی ژنیک برای اسکیزوفرنی و ارتباطات ساختاری مغز در سن بالاتر: مطالعه ی اتصال طولی و تراکتوگرافی
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کلمات کلیدی
جنون جوانی، سالخورده، اتصال سازمانی، طولی ژنتیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
Higher polygenic risk score for schizophrenia (szPGRS) has been associated with lower cognitive function and might be a predictor of decline in brain structure in apparently healthy populations. Age-related declines in structural brain connectivity-measured using white matter diffusion MRI -are evident from cross-sectional data. Yet, it remains unclear how graph theoretical metrics of the structural connectome change over time, and whether szPGRS is associated with differences in ageing-related changes in human brain connectivity. Here, we studied a large, relatively healthy, same-year-of-birth, older age cohort over a period of 3 years (ageâ¯â¼â¯73 years, Nâ¯=â¯731; age â¼76 years, Nâ¯=â¯488). From their brain scans we derived tract-averaged fractional anisotropy (FA) and mean diffusivity (MD), and network topology properties. We investigated the cross-sectional and longitudinal associations between these structural brain variables and szPGRS. Higher szPGRS showed significant associations with longitudinal increases in MD in the splenium (βâ¯=â¯0.132, pFDRâ¯=â¯0.040), arcuate (βâ¯=â¯0.291, pFDRâ¯=â¯0.040), anterior thalamic radiations (βâ¯=â¯0.215, pFDRâ¯=â¯0.040) and cingulum (βâ¯=â¯0.165, pFDRâ¯=â¯0.040). Significant declines over time were observed in graph theory metrics for FA-weighted networks, such as mean edge weight (βâ¯=â¯â0.039, pFDRâ¯=â¯0.048) and strength (βâ¯=â¯â0.027, pFDRâ¯=â¯0.048). No significant associations were found between szPGRS and graph theory metrics. These results are consistent with the hypothesis that szPGRS confers risk for ageing-related degradation of some aspects of structural connectivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 183, December 2018, Pages 884-896
Journal: NeuroImage - Volume 183, December 2018, Pages 884-896
نویسندگان
C. Alloza, S.R. Cox, M. Blesa Cábez, P. Redmond, H.C. Whalley, S.J. Ritchie, S. Muñoz Maniega, M. del C. Valdés Hernández, E.M. Tucker-Drob, S.M. Lawrie, J.M. Wardlaw, I.J. Deary, M.E. Bastin,