Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 α-amino acid by a α-hydroxy acid Fulltext Access 5 Pages 2005
Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists Fulltext Access 5 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS Fulltext Access 5 Pages 2005
Synthesis of alkyne derivatives of a novel triazolopyrazine as A2A adenosine receptor antagonists Fulltext Access 5 Pages 2005
Hybridization dependent cleavage of internally modified disulfide-peptide nucleic acids Fulltext Access 5 Pages 2005
Lysine derivatives as potent HIV protease inhibitors. Discovery, synthesis and structure-activity relationship studies Fulltext Access 5 Pages 2005
Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors Fulltext Access 5 Pages 2005
New derivatives of 1α,25-dihydroxy-19-norvitamin D3 with two substituents at C-2: synthesis and biological activity Fulltext Access 5 Pages 2005
Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors Fulltext Access 5 Pages 2005
Synthesis and in vitro antitrypanosomal activity of novel Nifurtimox analogues Fulltext Access 5 Pages 2005
Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine-5,7-diones and its application to the synthesis of GnRH antagonists Fulltext Access 5 Pages 2005
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor Fulltext Access 5 Pages 2005
Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives Fulltext Access 5 Pages 2005
Chiral polyamines from reduction of polypeptides: asymmetric pyridoxamine-mediated transaminations Fulltext Access 5 Pages 2005
(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents Fulltext Access 5 Pages 2005
cis-6-Oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-oxo-hexahydropyrrolo[3,2-c]pyrazole based scaffolds: design rationale, synthesis and cysteinyl proteinase inhibition Fulltext Access 5 Pages 2005
Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells Fulltext Access 5 Pages 2005
Design and synthesis of highly active Alzheimer's β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability Fulltext Access 5 Pages 2005
Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors Fulltext Access 5 Pages 2005
Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist Fulltext Access 5 Pages 2005
Enzymatic syntheses and selective hydrolysis of O-β-d-galactopyranosides using a marine mollusc β-galactosidase Fulltext Access 5 Pages 2005
A comparative binding study of BIV Tat peptide against its TAR RNA duplex, RNA-DNA heteroduplex and DNA duplex Fulltext Access 5 Pages 2005
Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides Fulltext Access 5 Pages 2005
Potent Kv1.3 inhibitors from correolide-modification of the C18 position Fulltext Access 5 Pages 2005
Novel estimation of lipophilicity using 13C NMR chemical shifts as molecular descriptor Fulltext Access 5 Pages 2005
Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus Fulltext Access 5 Pages 2005
N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists Fulltext Access 5 Pages 2005
Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design Fulltext Access 5 Pages 2005
Trypanocidal activity of (â)-cubebin derivatives against free amastigote forms of Trypanosoma cruzi Fulltext Access 5 Pages 2005
Detection of aptamer-protein interactions using QCM and electrochemical indicator methods Fulltext Access 5 Pages 2005
The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors Fulltext Access 5 Pages 2005
Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines Fulltext Access 5 Pages 2005
Specific recognition of napthyridine-based ligands toward guanine-containing bulges in RNA duplexes and RNA-DNA heteroduplexes Fulltext Access 5 Pages 2005
Comparative structural analysis of 5,6,7,9-tetra-O-acetyl-4,8-anhydro-1,3-dideoxy-d-glycero-l-gluco-nonulose and its 1-O-acetylated analog, 1,2,3,4,6-penta-O-acetyl-β-d-galactopyranose using X-ray crystallography Fulltext Access 5 Pages 2005
Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics Fulltext Access 5 Pages 2005
N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists Fulltext Access 5 Pages 2005
Increased catalytic activity of protein disulfide isomerase using aromatic thiol based redox buffers Fulltext Access 5 Pages 2005
3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity Fulltext Access 5 Pages 2005
Synthesis of 9-(2-β-C-methyl-β-d-ribofuranosyl)-6-substituted purine derivatives as inhibitors of HCV RNA replication Fulltext Access 5 Pages 2005
Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors Fulltext Access 5 Pages 2005
Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8 Fulltext Access 5 Pages 2005
Identification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cells Fulltext Access 5 Pages 2005
Enzymatic hydrolysis of stampidine and other stavudine phosphoramidates in the presence of mammalian proteases Fulltext Access 5 Pages 2005
Theoretical analysis of the retention behavior of alcohols in gas chromatography Fulltext Access 5 Pages 2005
Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ Fulltext Access 5 Pages 2005
New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human κ opioid receptors Fulltext Access 5 Pages 2005
Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds Fulltext Access 5 Pages 2005
Regioselective synthesis of cyclodextrin mono-substituted conjugates of non-steroidal anti-inflammatory drugs at C-2 secondary hydroxyl by protease in non-aqueous media Fulltext Access 5 Pages 2005
Synthesis and antimycobacterial evaluation of various 7-substituted ciprofloxacin derivatives Fulltext Access 5 Pages 2005
Carbonic anhydrase inhibitors: Inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides Fulltext Access 5 Pages 2005
Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion Fulltext Access 5 Pages 2005
Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral α-helix peptides Fulltext Access 5 Pages 2005
Sesterterpenoids and an alkaloid from a Thorectandra sp. as inhibitors of the phosphatase Cdc25B Fulltext Access 5 Pages 2005
A proposed molecular basis for the selective resveratrol inhibition of the PGHS-1 peroxidase activity Fulltext Access 5 Pages 2005
Solution conformations of two naturally occurring RNA nucleosides: 3-Methyluridine and 3-methylpseudouridine Fulltext Access 5 Pages 2005
A synthetic approach to the generation of quercetin sulfates and the detection of quercetin 3′-O-sulfate as a urinary metabolite in the rat Fulltext Access 5 Pages 2005
A mild and environmentally friendly scandium(III) trifluoromethanesulfonate-catalyzed synthesis of bis(3′-indolyl)alkanes and bis(3′-indolyl)-1-deoxyalditols Fulltext Access 5 Pages 2005
Synthesis of the tetrasaccharide α-d-Glcp-(1→3)-α-d-Manp-(1→2)-α-d-Manp-(1→2)-α-d-Manp recognized by Calreticulin/Calnexin Fulltext Access 5 Pages 2005
Synthesis of sterically crowded derivatives of anomeric pairs of d-glucose disaccharides Fulltext Access 5 Pages 2005
The O-chain structure from the LPS of marine halophilic bacterium Pseudoalteromonas carrageenovora-type strain IAM 12662T Fulltext Access 5 Pages 2005
Glycosyl trichloroacetylcarbamate: a new glycosyl donor for O-glycosylation Fulltext Access 5 Pages 2005
Regio- and stereoselective cyclizations of dianhydro sugar alcohols catalyzed by a chiral (salen)CoIII complex Fulltext Access 5 Pages 2005
The structure of a polysaccharide isolated from Inonotus levis P. Karst. mushroom (Heterobasidiomycetes) Fulltext Access 5 Pages 2005
Synthesis and biological activity of N-methylated analogs of endomorphin-2 Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390 Fulltext Access 5 Pages 2005
Quantitative structure–activity relationship studies of vitamin D receptor affinity for analogues of 1α,25-dihydroxyvitamin D3. 1: WHIM descriptors Fulltext Access 5 Pages 2005
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis Fulltext Access 5 Pages 2005
Estrogen receptor ligands. Part 14: Application of novel antagonist side chains to existing platforms Fulltext Access 5 Pages 2005
Mild and efficient oxidation of alcohols with sodium periodate catalyzed by polystyrene-bound Mn(III)porphyrin Fulltext Access 5 Pages 2005
Synthesis of DEHP metabolites as biomarkers for GC–MS evaluation of phthalates as endocrine disrupters Fulltext Access 5 Pages 2005
A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria) Fulltext Access 5 Pages 2005