Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity Fulltext Access 5 Pages 2005
The molecular crystal structure and self-assembly behavior of 6I-O-(3-nitrophenyl)cyclomaltoheptaose Fulltext Access 5 Pages 2005
Studies on the synthesis of safflomin-A, a yellow pigment in safflower petals: oxidation of 3-C-β-d-glucopyranosyl-5-methylphloroacetophenone Fulltext Access 5 Pages 2005
Ramachandran free-energy surfaces for disaccharides: trehalose, a case study Fulltext Access 5 Pages 2005
Polysaccharide structures from powder diffraction data: molecular models of arabinan Fulltext Access 5 Pages 2005
Periodate oxidation of sodium alginate in water and in ethanol-water mixture: a comparative study Fulltext Access 5 Pages 2005
The O-polysaccharide from the lipopolysaccharide of Providencia stuartii O44 contains l-quinovose, a 6-deoxy sugar rarely occurring in bacterial polysaccharides Fulltext Access 5 Pages 2005
Structure of the O-polysaccharide from the lipopolysaccharide of Providencia stuartii O43 containing an amide of d-galacturonic acid with l-serine Fulltext Access 5 Pages 2005
Direct one-pot conversion of acylated carbohydrates into their alkylated derivatives under heterogeneous reaction conditions using solid NaOH and a phase transfer catalyst Fulltext Access 5 Pages 2005
Possible role of hydroxyl radicals in the oxidative degradation of folic acid Fulltext Access 5 Pages 2005
Structure of an acidic polysaccharide from the marine bacterium Pseudoalteromonas aliena type strain KMM 3562T containing two residues of l-serine in the repeating unit Fulltext Access 5 Pages 2005
2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents Fulltext Access 5 Pages 2005
Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist Fulltext Access 5 Pages 2005
Further studies on ethenyl and ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of a subnanomolar Src kinase inhibitor Fulltext Access 5 Pages 2005
A two-state homology model of the hERG K+ channel: application to ligand binding Fulltext Access 5 Pages 2005
A chromism-based assay (CHROBA) technique for in situ detection of protein kinase activity Fulltext Access 5 Pages 2005
Synthesis and fluorescence studies of thiazole orange tethered onto oligonucleotide: development of a self-contained DNA biosensor on a fiber optic surface Fulltext Access 5 Pages 2005
1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands Fulltext Access 5 Pages 2005
Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands Fulltext Access 5 Pages 2005
Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors Fulltext Access 5 Pages 2005
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs) Fulltext Access 5 Pages 2005
Structural analysis of the O-antigen polysaccharide from Escherichia coli O152 Fulltext Access 5 Pages 2005
Structure of the O-polysaccharide from the Azospirillum lipoferum Sp59b lipopolysaccharide Fulltext Access 5 Pages 2005
Structural analysis of the core oligosaccharide from Pasteurella multocida strain X73 Fulltext Access 5 Pages 2005
A new neutral polymer from the cell wall of actinomycete Kineosporia aurantiaca VKM Ac-702T Fulltext Access 5 Pages 2005
An expedient synthesis of benzyl 2,3,4-tri-O-benzyl-β-d-glucopyranoside and benzyl 2,3,4-tri-O-benzyl-β-d-mannopyranoside Fulltext Access 5 Pages 2005
Study on the synergetic degradation of chitosan with ultraviolet light and hydrogen peroxide Fulltext Access 5 Pages 2005
Structural characterisation of a highly branched exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus NCFB2074 Fulltext Access 5 Pages 2005
Synthesis of bis-(methyl 3,4,6-tri-O-acetyl-D-glucopyranosid-2-yl)-oxamides Fulltext Access 5 Pages 2005
AFM studies of water-soluble wheat arabinoxylans-effects of esterase treatment Fulltext Access 5 Pages 2005
An efficient and concise synthesis of a β-(1â6)-linked d-galactofuranosyl hexasaccharide Fulltext Access 5 Pages 2005
Synthesis of methyl 4,6-O-benzylidene-2,3-dideoxy-2-C-formyl-α-d-erythro-hex-2-enopyranoside Fulltext Access 5 Pages 2005
Synthesis, crystal structure, and high-resolution NMR spectroscopy of methyl 3-azido-2,3-dideoxy-4,6-di-O-p-tolylsulfonyl-α-d-xylo-hexopyranoside Fulltext Access 5 Pages 2005
Enzymatic procedures in the preparation of regioprotected d-fructose derivatives Fulltext Access 5 Pages 2005
Synthesis of alkyl and aryl C-pyranosides using organozinc reagents via a Ferrier-type rearrangement Fulltext Access 5 Pages 2005
Structural analyses of novel glycerophosphorylated α-cyclosophorohexadecaoses isolated from X. campestris pv. campestris Fulltext Access 5 Pages 2005
Structure of the O-specific polysaccharide from Shewanella japonica type strain KMM 3299T containing the rare amino sugar Fuc4NAc Fulltext Access 5 Pages 2005
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2 Fulltext Access 5 Pages 2005
Syntheses and properties of the major hydroxy metabolites in humans of blonanserin AD-5423, a novel antipsychotic agent Fulltext Access 5 Pages 2005
Spiro-annulation of barbituric acid derivatives and its analogs by ring-closing metathesis reaction Fulltext Access 5 Pages 2005
Synthesis and biological activity evaluation of lignan lactones derived from (â)-cubebin Fulltext Access 5 Pages 2005
Synthesis of mono-glucose-branched cyclodextrins with a high inclusion ability for doxorubicin and their efficient glycosylation using Mucor hiemalis endo-β-N-acetylglucosaminidase Fulltext Access 5 Pages 2005
Identification of nonpeptidic small-molecule inhibitors of interleukin-2 Fulltext Access 5 Pages 2005
QSAR of estrogen receptor modulators: exploring selectivity requirements for ERα versus ERβ binding of tetrahydroisoquinoline derivatives using E-state and physicochemical parameters Fulltext Access 5 Pages 2005
A rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butylcarbamates Fulltext Access 5 Pages 2005
Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP Fulltext Access 5 Pages 2005
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors Fulltext Access 5 Pages 2005
The development of potent and selective bisarylmaleimide GSK3 inhibitors Fulltext Access 5 Pages 2005
Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes Fulltext Access 5 Pages 2005
6â²-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the α4β2 nicotinic receptor pharmacophore model Fulltext Access 5 Pages 2005
Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine Fulltext Access 5 Pages 2005
Crystal structure of methyl 3-amino-2,3-dideoxy-β-d-arabino-hexopyranoside. Stabilization of the crystal lattice by a double network of N-Hâ¯O, O-Hâ¯N and O-Hâ¯O interactions Fulltext Access 5 Pages 2005
A strategy to profile prime and non-prime proteolytic substrate specificity Fulltext Access 5 Pages 2005
Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives Fulltext Access 5 Pages 2005
Structure–activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors Fulltext Access 5 Pages 2005
Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: Orally active prostacyclin mimetics. Part 3 Fulltext Access 5 Pages 2005
Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease Fulltext Access 5 Pages 2005
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential Fulltext Access 5 Pages 2005
Quaternary salts of 4,3′ and 4,4′ bis-pyridinium monooximes: Synthesis and biological activity Fulltext Access 5 Pages 2005
Total asymmetric synthesis of (−)-conduramine B-1 and of its enantiomer. N-Benzyl derivatives of conduramine B-1 are β-glucosidase inhibitors Fulltext Access 5 Pages 2005
Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors Fulltext Access 5 Pages 2005
1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors Fulltext Access 5 Pages 2005
Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides Fulltext Access 5 Pages 2005
Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design Fulltext Access 5 Pages 2005
Design, synthesis, and biological activity of novel PPARγ ligands based on rosiglitazone and 15d-PGJ2 Fulltext Access 5 Pages 2005
Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases Fulltext Access 5 Pages 2005
Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1 Fulltext Access 5 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides Fulltext Access 5 Pages 2005
Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors Fulltext Access 5 Pages 2005
Structure-activity relationship study of novel tissue transglutaminase inhibitors Fulltext Access 5 Pages 2005
Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome Fulltext Access 5 Pages 2005
Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists Fulltext Access 5 Pages 2005
Fluorescent metal ion indicators based on benzoannelated crown systems: a green fluorescent indicator for intracellular sodium ions Fulltext Access 5 Pages 2005
4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR Fulltext Access 5 Pages 2005
Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships Fulltext Access 5 Pages 2005
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents Fulltext Access 5 Pages 2005
QSAR-by-NMR: quantitative insights into structural determinants for binding affinity by analysis of 1H/15N chemical shift differences in MMP-3 ligands Fulltext Access 5 Pages 2005
Kinetic model studies on the chemical ligation of oligonucleotides via hydrazone formation Fulltext Access 5 Pages 2005
Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines Fulltext Access 5 Pages 2005
2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity Fulltext Access 5 Pages 2005
Synthesis and evaluation of novel peripherally restricted κ-opioid receptor agonists Fulltext Access 5 Pages 2005