Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines Fulltext Access 5 Pages 2005
Induction of apoptosis by a novel indirubin-5-nitro-3′-monoxime, a CDK inhibitor, in human lung cancer cells Fulltext Access 5 Pages 2005
Bradykinin B1 antagonists: SAR studies in the 2,3-diaminopyridine series Fulltext Access 5 Pages 2005
Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain Fulltext Access 5 Pages 2005
Ketoheterocycle-based inhibitors of cathepsin K: A novel entry into the synthesis of peptidic ketoheterocycles Fulltext Access 5 Pages 2005
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors Fulltext Access 5 Pages 2005
Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers Fulltext Access 5 Pages 2005
Synthesis of an N-acyl sulfamate analog of luciferyl-AMP: A stable and potent inhibitor of firefly luciferase Fulltext Access 5 Pages 2005
SAR and biological evaluation of novel trans-3,4-dimethyl-4-arylpiperidine derivatives as opioid antagonists Fulltext Access 5 Pages 2005
A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series Fulltext Access 5 Pages 2005
Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3 Fulltext Access 5 Pages 2005
Synthesis of doxorubicin–peptide conjugate with multidrug resistant tumor cell killing activity Fulltext Access 5 Pages 2005
Structure–activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3-(substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption Fulltext Access 5 Pages 2005
Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor Fulltext Access 5 Pages 2005
High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization Fulltext Access 5 Pages 2005
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists Fulltext Access 5 Pages 2005
Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases Fulltext Access 5 Pages 2005
Bis(indole) alkaloids as sortase A inhibitors from the sponge Spongosorites sp. Fulltext Access 5 Pages 2005
Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides Fulltext Access 5 Pages 2005
Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes Fulltext Access 5 Pages 2005
Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia Fulltext Access 5 Pages 2005
Induced resistance and allocation costs: What is the impact of pathogen challenge? Fulltext Access 5 Pages 2005
In vitro characterization of radioiodinated (+)-2-[4-(4-iodophenyl) piperidino]cyclohexanol [(+)-pIV] as a sigma-1 receptor ligand Fulltext Access 5 Pages 2005
Halenaquinone and xestoquinone derivatives, inhibitors of Cdc25B phosphatase from a Xestospongia sp. Fulltext Access 5 Pages 2005
In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor Fulltext Access 5 Pages 2005
A new route to trihydroxamate-containing artificial siderophores and synthesis of a new fluorescent probe Fulltext Access 5 Pages 2005
Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro Fulltext Access 5 Pages 2005
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles Fulltext Access 5 Pages 2005
Certain factors associated with blister blight resistance in Camellia sinensis (L.) O. Kuntze Fulltext Access 5 Pages 2005
Dinophilidae (Annelida) is most likely not a progenetic Eunicida: Evidence from 18S and 28S rDNA Fulltext Access 5 Pages 2005
A phylogenetic analysis of Epimedium (Berberidaceae) based on nuclear ribosomal DNA sequences Fulltext Access 5 Pages 2005
Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1H-benzimidazol-5-yl)-3-tert-butylurea derivatives Fulltext Access 5 Pages 2005
Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor Fulltext Access 5 Pages 2005
Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain Fulltext Access 5 Pages 2005
Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action Fulltext Access 5 Pages 2005
A structural screening approach to ketoamide-based inhibitors of cathepsin K Fulltext Access 5 Pages 2005
Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors Fulltext Access 5 Pages 2005
Effects of linking 15-zinc finger domains on DNA binding specificity and multiple DNA binding modes Fulltext Access 5 Pages 2005
Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides Fulltext Access 5 Pages 2005
Sialyl Lewisx analogs based on a quinic acid scaffold as the fucose mimic Fulltext Access 5 Pages 2005
Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein Fulltext Access 5 Pages 2005
Estrogen receptor β selective ligands: Discovery and SAR of novel heterocyclic ligands Fulltext Access 5 Pages 2005
A novel one-pot three-component reaction: Synthesis of triheterocyclic 4H-pyrimido[2,1-b]benzazoles ring systems Fulltext Access 5 Pages 2005
Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata Fulltext Access 5 Pages 2005
Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1) Fulltext Access 5 Pages 2005
Molecular docking and 3D-QSAR on 2-(oxalylamino) benzoic acid and its analogues as protein tyrosine phosphatase 1B inhibitors Fulltext Access 5 Pages 2005
Preparation of human Melanocortin-4 receptor agonist libraries: Linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2 Fulltext Access 5 Pages 2005
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains Fulltext Access 5 Pages 2005
Toll-like receptor 2 antagonists. Part 1: Preliminary SAR investigation of novel synthetic phospholipids Fulltext Access 5 Pages 2005
A practical molecular clip for immobilization of receptors and biomolecules on devices’ surface: Synthesis, grafting protocol and analytical assay Fulltext Access 5 Pages 2005
Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists Fulltext Access 5 Pages 2005
Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors Fulltext Access 5 Pages 2005
Synthesis and structure–activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II Fulltext Access 5 Pages 2005
Synthesis, spectral studies and in vitro assessment for antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones Fulltext Access 5 Pages 2005
N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands Fulltext Access 5 Pages 2005
Selection of 5′-untranslated sequences that enhance initiation of translation in a cell-free protein synthesis system from wheat embryos Fulltext Access 5 Pages 2005
Synthesis and in vitro anti-hepatitis B and C virus activities of ring-expanded ('fat') nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system Fulltext Access 5 Pages 2005
Photoisomerization as a trigger for Bergman cyclization: Synthesis and reactivity of azoenediynes Fulltext Access 5 Pages 2005
Factors affecting the protease activity of venom from jellyfish Rhopilema esculentum Kishinouye Fulltext Access 5 Pages 2005
Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor Fulltext Access 5 Pages 2005
Design, synthesis, and evaluation of proline based melanocortin receptor ligands Fulltext Access 5 Pages 2005
Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry Fulltext Access 5 Pages 2005
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain Fulltext Access 5 Pages 2005
Discovery of selective aldo-keto reductase ligands—an on-bead assay strategy Fulltext Access 5 Pages 2005
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity Fulltext Access 5 Pages 2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors Fulltext Access 5 Pages 2005
Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes Fulltext Access 5 Pages 2005
Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5) Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I Fulltext Access 5 Pages 2005
Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization Fulltext Access 5 Pages 2005
Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates Fulltext Access 5 Pages 2005
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters Fulltext Access 5 Pages 2005
Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs) Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors Fulltext Access 5 Pages 2005
Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives Fulltext Access 5 Pages 2005
Decrease in the particle size of low-density lipoprotein (LDL) by oxidation Fulltext Access 5 Pages 2005
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum Fulltext Access 5 Pages 2005
P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold Fulltext Access 5 Pages 2005
Synthesis of all-trans arachidonic acid and its effect on rabbit platelet aggregation Fulltext Access 5 Pages 2005
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2) Fulltext Access 5 Pages 2005
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors Fulltext Access 5 Pages 2005
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: Toward agents for boron neutron capture therapy of hypoxic tumo Fulltext Access 5 Pages 2005
Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: Orally active prostacyclin mimetics. Part 2 Fulltext Access 5 Pages 2005
Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors Fulltext Access 5 Pages 2005