Peroxiredoxin-I is an autoimmunogenic tumor antigen in non-small cell lung cancer Fulltext Access 5 Pages 2005
Phenylalanine ammonia lyase, enzyme substitution therapy for phenylketonuria, where are we now? Fulltext Access 5 Pages 2005
Response of patients with phenylketonuria in the US to tetrahydrobiopterin Fulltext Access 5 Pages 2005
Determination of human plasma phospholipid transfer protein mass and activity Fulltext Access 5 Pages 2005
The use of transgenic mice to study cytoprotection by the stress proteins Fulltext Access 5 Pages 2005
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction Fulltext Access 5 Pages 2005
Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin Fulltext Access 5 Pages 2005
Quantitative measurement of events in the mammalian unfolded protein response Fulltext Access 5 Pages 2005
Fluorophore-assisted carbohydrate electrophoresis: a sensitive and accurate method for the direct analysis of dolichol pyrophosphate-linked oligosaccharides in cell cultures and tissues Fulltext Access 5 Pages 2005
Gateway cloning is compatible with protein secretion from Pichia pastoris Fulltext Access 5 Pages 2005
An alternative use of basic pGEX vectors for producing both N- and C-terminal fusion proteins for production and affinity purification of antibodies Fulltext Access 5 Pages 2005
Tetrahydrobiopterin-responsive phenylketonuria: The New South Wales experience Fulltext Access 5 Pages 2005
Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines Fulltext Access 5 Pages 2005
Zinc ions selectively inhibit steps associated with binding and release of NADP(H) during turnover of proton-translocating transhydrogenase Fulltext Access 5 Pages 2005
The longin domain regulates subcellular targeting of VAMP7 in Arabidopsis thaliana Fulltext Access 5 Pages 2005
Identification and characterisation of Arabidopsis glycosyltransferases capable of glucosylating coniferyl aldehyde and sinapyl aldehyde Fulltext Access 5 Pages 2005
Heat stable ssDNA/RNA-binding activity of a wheat cold shock domain protein Fulltext Access 5 Pages 2005
Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy Fulltext Access 5 Pages 2005
Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins Fulltext Access 5 Pages 2005
A previously found thylakoid membrane protein of 14 kDa (TMP14) is a novel subunit of plant photosystem I and is designated PSI-P Fulltext Access 5 Pages 2005
Deletion of flavoredoxin gene in Desulfovibrio gigas reveals its participation in thiosulfate reduction Fulltext Access 5 Pages 2005
Disruption of perlecan binding and matrix assembly by post-translational or genetic disruption of dystroglycan function Fulltext Access 5 Pages 2005
Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes Fulltext Access 5 Pages 2005
Refolding and one-step purification of recombinant human ARA70 over-expressed in Escherichia coli Fulltext Access 5 Pages 2005
Cloning, expression, and refolding of a secretory protein ESAT-6 of Mycobacterium tuberculosis Fulltext Access 5 Pages 2005
Efficient production of Clostridium botulinum exotoxin C3 in bacteria: a screening method to optimize production yields Fulltext Access 5 Pages 2005
Purification of streptomycin adenylyltransferase from a recombinant Escherichia coli Fulltext Access 5 Pages 2005
The T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy Fulltext Access 5 Pages 2005
Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns Fulltext Access 5 Pages 2005
Reconstitution of functional nuclear receptor proteins using high pressure refolding Fulltext Access 5 Pages 2005
Clinical, pathological, and biochemical studies in a patient with propionic acidemia and fatal cardiomyopathy Fulltext Access 5 Pages 2005
Gastrointestinal manifestations of Fabry disease: Clinical response to enzyme replacement therapy Fulltext Access 5 Pages 2005
Genetic variation in the proto-oncogene SKI and risk for orofacial clefting Fulltext Access 5 Pages 2005
Excitation energy trapping in photosystem I complexes depleted in Lhca1 and Lhca4 Fulltext Access 5 Pages 2005
Synergistic heterozygosity in mice with inherited enzyme deficiencies of mitochondrial fatty acid β-oxidation Fulltext Access 5 Pages 2005
Detection of mutations in the glycine decarboxylase gene in patients with nonketotic hyperglycinaemia Fulltext Access 5 Pages 2005
Characterization of 11 novel mutations in the tissue non-specific alkaline phosphatase gene responsible for hypophosphatasia and genotype-phenotype correlations Fulltext Access 5 Pages 2005
Four new mutations in the BCHE gene of human butyrylcholinesterase in a Brazilian blood donor sample Fulltext Access 5 Pages 2005
Common polymorphisms in the PPARγ2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men Fulltext Access 5 Pages 2005
Neonatal hyperphenylalaninemia, perinatal hemochromatosis, and renal tubulopathy: A unique patient or a novel metabolic disorder? Fulltext Access 5 Pages 2005
Inter-individual variation in brain phenylalanine concentration in patients with PKU is not caused by genetic variation in the 4F2hc/LAT1 complex Fulltext Access 5 Pages 2005
Extended tetrahydrobiopterin loading test in the diagnosis of cofactor-responsive phenylketonuria: A pilot study Fulltext Access 5 Pages 2005
Long-term treatment with tetrahydrobiopterin increases phenylalanine tolerance in children with severe phenotype of phenylketonuria Fulltext Access 5 Pages 2005
Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors Fulltext Access 5 Pages 2005
Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist Fulltext Access 5 Pages 2005
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists Fulltext Access 5 Pages 2005
Design, synthesis, and structure–activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis Fulltext Access 5 Pages 2005
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells Fulltext Access 5 Pages 2005
Screening of active compounds as neuromedin U2 receptor agonist from natural products Fulltext Access 5 Pages 2005
An efficient synthesis of aryloxyphenyl cyclopropyl methanones: a new class of anti-mycobacterial agents Fulltext Access 5 Pages 2005
Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2–P1 cyclopropyl alanine combination for improved potency Fulltext Access 5 Pages 2005
Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2â²,2â²-diphenylpropionoxymethyl)pyridinium Fulltext Access 5 Pages 2005
Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives Fulltext Access 5 Pages 2005
Synthesis and cytotoxic activity of platinum complex immobilized by branched polyethylene glycol Fulltext Access 5 Pages 2005
Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles Fulltext Access 5 Pages 2005
Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives Fulltext Access 5 Pages 2005
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of novel (l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents Fulltext Access 5 Pages 2005
Inhibitors of phenylethanolamine N-methyltransferase devoid of α2-adrenoceptor affinity Fulltext Access 5 Pages 2005
Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors Fulltext Access 5 Pages 2005
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists Fulltext Access 5 Pages 2005
Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure–activity relationships Fulltext Access 5 Pages 2005
2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV Fulltext Access 5 Pages 2005
Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1 Fulltext Access 5 Pages 2005
3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone Fulltext Access 5 Pages 2005
Yeast oligosaccharyltransferase consists of two functionally distinct sub-complexes, specified by either the Ost3p or Ost6p subunit Fulltext Access 5 Pages 2005
The upstream area of the chicken α-globin gene domain is transcribed in both directions in the same cells Fulltext Access 5 Pages 2005
Effects of N-acylethanolamines on the respiratory chain and production of reactive oxygen species in heart mitochondria Fulltext Access 5 Pages 2005
Impairment of the activity of the xenobiotic-metabolizing enzymes arylamine N-acetyltransferases 1 and 2 (NAT1/NAT2) by peroxynitrite in mouse skeletal muscle cells Fulltext Access 5 Pages 2005
LEAFY COTYLEDON 2 activation is sufficient to trigger the accumulation of oil and seed specific mRNAs in Arabidopsis leaves Fulltext Access 5 Pages 2005
Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting Fulltext Access 5 Pages 2005
Functional essentiality from topology features in metabolic networks: A case study in yeast Fulltext Access 5 Pages 2005
Defective binding of transcriptional repressor ZEB via DNA methylation contributes to increased constitutive levels of p73 in Fanconi anemia cells Fulltext Access 5 Pages 2005
NosX function connects to nitrous oxide (N2O) reduction by affecting the CuZ center of NosZ and its activity in vivo Fulltext Access 5 Pages 2005
X-ray structure of the γ-subunit of a dissimilatory sulfite reductase: Fixed and flexible C-terminal arms Fulltext Access 5 Pages 2005
Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH Fulltext Access 5 Pages 2005
Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: Inhibitory effects and occurrence in A7r5 cells Fulltext Access 5 Pages 2005
Carbonic anhydrase inhibitors: Inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides Fulltext Access 5 Pages 2005
N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities Fulltext Access 5 Pages 2005
Structure–activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads Fulltext Access 5 Pages 2005
Hydantoin derivative formation from oxidation of 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxodG) and incorporation of 14C-labeled 8-oxodG into the DNA of human breast cancer cells Fulltext Access 5 Pages 2005
Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists Fulltext Access 5 Pages 2005
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: Discovery of potent S1P1 receptor agonists Fulltext Access 5 Pages 2005
Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors Fulltext Access 5 Pages 2005
Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase Fulltext Access 5 Pages 2005
Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1 Fulltext Access 5 Pages 2005
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subt Fulltext Access 5 Pages 2005