Design and synthesis of novel bis(l-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity Fulltext Access 6 Pages 2007
Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: A semi-empirical investigation Fulltext Access 6 Pages 2007
N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists Fulltext Access 6 Pages 2007
Structure–activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase Fulltext Access 6 Pages 2007
Identification of potent and selective TACE inhibitors via the S1 pocket Fulltext Access 6 Pages 2007
Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease Fulltext Access 6 Pages 2007
Chemically programmed antibodies: Endothelin receptor targeting CovX-Bodies™ Fulltext Access 6 Pages 2007
Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: Implication for targeting protein kinases in metabolic diseases Fulltext Access 6 Pages 2007
Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers Fulltext Access 6 Pages 2007
2-Arylidenedihydroindole-3-ones: Design, synthesis, and biological activity on bladder carcinoma cell lines Fulltext Access 6 Pages 2007
Isoindolone derivatives, a new class of 5-HT2C antagonists: Synthesis and biological evaluation Fulltext Access 6 Pages 2007
Studies towards the identification of a new generation of atypical antipsychotic agents Fulltext Access 6 Pages 2007
Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors Fulltext Access 6 Pages 2007
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors Fulltext Access 6 Pages 2007
α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists Fulltext Access 6 Pages 2007
Structure–activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II Fulltext Access 6 Pages 2007
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties Fulltext Access 6 Pages 2007
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents Fulltext Access 6 Pages 2007
Effects of a mixture of fatty acids from sugar cane (Saccharum officinarum L.) wax oil in two models of inflammation: Zymosan-induced arthritis and mice tail test of psoriasis Fulltext Access 6 Pages 2007
Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract Fulltext Access 6 Pages 2007
The effect of extracts from ginger rhizome on inflammatory mediator production Fulltext Access 6 Pages 2007
Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid Fulltext Access 6 Pages 2007
Antipyretic effect of Mao-to, a Japanese herbal medicine, for treatment of type A influenza infection in children Fulltext Access 6 Pages 2007
Antiulcerogenic potential of Strychnos potatorum Linn seeds on Aspirin plus pyloric ligation-induced ulcers in experimental rats Fulltext Access 6 Pages 2007
Down-regulation of prostate specific antigen in LNCaP cells by flavonoids from the pollen of Brassica napus L. Fulltext Access 6 Pages 2007
Stimulating effects on mouse splenocytes of glycoproteins from the herbal medicine Atractylodes macrocephala Koidz. Fulltext Access 6 Pages 2007
Synergic effect of grape seed extract with amphotericin B against disseminated candidiasis due to Candida albicans Fulltext Access 6 Pages 2007
Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin Fulltext Access 6 Pages 2007
From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-β-carbolines: A new class of orally bioavailable mGluR1 antagonists Fulltext Access 6 Pages 2007
Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide Fulltext Access 6 Pages 2007
Effect of sun ginseng methanol extract on lipopolysaccharide-induced liver injury in rats Fulltext Access 6 Pages 2007
Cranberry juice improved antioxidant status without affecting bone quality in orchidectomized male rats Fulltext Access 6 Pages 2007
Extract of Pelargonium sidoides (EPs® 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro Fulltext Access 6 Pages 2007
Treatment of rats with the Pelargonium sidoides extract EPs® 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin Fulltext Access 6 Pages 2007
Therapeutic effects of Saireito (TJ-114), a traditional Japanese herbal medicine, on postoperative edema and inflammation after total hip arthroplasty Fulltext Access 6 Pages 2007
Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: Identification of a lead and initial SAR studies Fulltext Access 6 Pages 2007
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE) Fulltext Access 6 Pages 2007
Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin Fulltext Access 6 Pages 2007
Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) δ agonists Fulltext Access 6 Pages 2007
CC chemokine receptor-3 (CCR3) antagonists: Improving the selectivity of DPC168 by reducing central ring lipophilicity Fulltext Access 6 Pages 2007
C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists Fulltext Access 6 Pages 2007
Design and synthesis of novel hydantoin-containing melanin-concentrating hormone receptor antagonists Fulltext Access 6 Pages 2007
Docking-based 3D-QSAR study for selectivity of DPP4, DPP8, and DPP9 inhibitors Fulltext Access 6 Pages 2007
Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats Fulltext Access 6 Pages 2007
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis Fulltext Access 6 Pages 2007
Synthesis and anthelmintic activity of cyclohexadepsipeptides with cyclohexylmethyl side chains Fulltext Access 6 Pages 2007
A new class of histamine H3 receptor antagonists derived from ligand based design Fulltext Access 6 Pages 2007
Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors Fulltext Access 6 Pages 2007
3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2 Fulltext Access 6 Pages 2007
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor δ agonists Fulltext Access 6 Pages 2007
Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2 Fulltext Access 6 Pages 2007
1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies Fulltext Access 6 Pages 2007
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors Fulltext Access 6 Pages 2007
Structure–activity relationships of SERMs optimized for uterine antagonism and ovarian safety Fulltext Access 6 Pages 2007
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics Fulltext Access 6 Pages 2007
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents Fulltext Access 6 Pages 2007
Synthesis and structure–activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-β inhibitors Fulltext Access 6 Pages 2007
Optimization of novel combi-molecules: Identification of balanced and mixed bcr-abl/DNA targeting properties Fulltext Access 6 Pages 2007
New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site Fulltext Access 6 Pages 2007
Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: Oxadiazolyl ketones Fulltext Access 6 Pages 2007
Novel selective PPARδ agonists: Optimization of activity by modification of alkynylallylic moiety Fulltext Access 6 Pages 2007
Carbonic anhydrase activators: Activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines Fulltext Access 6 Pages 2007
Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives Fulltext Access 6 Pages 2007
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I Fulltext Access 6 Pages 2007
The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents Fulltext Access 6 Pages 2007
Synthesis and biological activity of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety as novel angiotensin II AT1 receptor antagonists Fulltext Access 6 Pages 2007
Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3 Fulltext Access 6 Pages 2007
Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors Fulltext Access 6 Pages 2007
Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases Fulltext Access 6 Pages 2007
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids Fulltext Access 6 Pages 2007
Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent Fulltext Access 6 Pages 2007
Synthesis and in vitro photodynamic activities of water-soluble fluorinated tetrapyridylporphyrins as tumor photosensitizers Fulltext Access 6 Pages 2007
2-(2-(2-Ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzamine inhibits EAT cell induced angiogenesis by down regulation of VEGF secretion Fulltext Access 6 Pages 2007
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE) Fulltext Access 6 Pages 2007
Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk Fulltext Access 6 Pages 2007
Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity Fulltext Access 6 Pages 2007
Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein Fulltext Access 6 Pages 2007
Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: Benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety Fulltext Access 6 Pages 2007
Structure function analysis of benzalacetone synthase from Rheum palmatum Fulltext Access 6 Pages 2007
β-Substituted cyclohexanecarboxamide cathepsin K inhibitors: Modification of the 1,2-disubstituted aromatic core Fulltext Access 6 Pages 2007
Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity Fulltext Access 6 Pages 2007
Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors Fulltext Access 6 Pages 2007
The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer Fulltext Access 6 Pages 2007
Potent anti-obese principle from Rosa canina: Structural requirements and mode of action of trans-tiliroside Fulltext Access 6 Pages 2007
Ligand based virtual screening and biological evaluation of inhibitors of chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv Fulltext Access 6 Pages 2007
Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: Impacts of glutathione trapping and glucuronide conjugation on covalent binding Fulltext Access 6 Pages 2007