Facile synthesis of substituted thiophenes via Pd/C-mediated sonogashira coupling in water Fulltext Access 5 Pages 2006
Discovery and initial development of a novel class of antibacterials: Inhibitors of Staphylococcus aureus transcription/translation Fulltext Access 5 Pages 2006
Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists Fulltext Access 5 Pages 2006
Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense Fulltext Access 5 Pages 2006
Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors Fulltext Access 5 Pages 2006
Biocatalytic ammonolysis of (5S)-4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester: Preparation of an intermediate to the dipeptidyl peptidase IV inhibitor Saxagliptin Fulltext Access 5 Pages 2006
Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors Fulltext Access 5 Pages 2006
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists Fulltext Access 5 Pages 2006
Side-chain modified analogues of histaprodifen: Asymmetric synthesis and histamine H1-receptor activity Fulltext Access 5 Pages 2006
Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase Fulltext Access 5 Pages 2006
Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives Fulltext Access 5 Pages 2006
Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues Fulltext Access 5 Pages 2006
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II Fulltext Access 5 Pages 2006
N-(Aryl)-4-(azolylethyl)thiazole-5-carboxamides: Novel potent inhibitors of VEGF receptors I and II Fulltext Access 5 Pages 2006
The electronic structure of human erythropoietin as an aid in the design of oxidation-resistant therapeutic proteins Fulltext Access 5 Pages 2006
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor α/δ dual agonists Fulltext Access 5 Pages 2006
Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to l-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase Fulltext Access 5 Pages 2006
Guiding farnesyltransferase inhibitors from an ECLiPS® library to the catalytic zinc Fulltext Access 5 Pages 2006
Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: 1H-Pyrimidin-2-one derivatives Fulltext Access 5 Pages 2006
Relationship between the lipophilicity of gallic acid n-alquil esters' derivatives and both myeloperoxidase activity and HOCl scavenging Fulltext Access 5 Pages 2006
Biosynthesis of acaterin: Mechanism of the reaction catalyzed by dehydroacaterin reductase Fulltext Access 5 Pages 2006
Biological evaluation of newly synthesized quinoline-5,8-quinones as Cdc25B inhibitors Fulltext Access 5 Pages 2006
Peptide–polyethylene glycol conjugates: Synthesis and properties of peptides bearing a C-terminal polyethylene glycol chain Fulltext Access 5 Pages 2006
4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists Fulltext Access 5 Pages 2006
Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes Fulltext Access 5 Pages 2006
Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases Fulltext Access 5 Pages 2006
Synthesis and biological evaluation of copper (II) complexes of sterically hindered o-aminophenol derivatives as antimicrobial agents Fulltext Access 5 Pages 2006
Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp. Fulltext Access 5 Pages 2006
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains Fulltext Access 5 Pages 2006
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors Fulltext Access 5 Pages 2006
Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitors Fulltext Access 5 Pages 2006
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A new class of pestivirus inhibitors Fulltext Access 5 Pages 2006
Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds Fulltext Access 5 Pages 2006
Synthesis and anti-HIV-1 activity of a novel series of 1,4,2-benzodithiazine-dioxides Fulltext Access 5 Pages 2006
Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14α-demethylase (CYP51) of fungi Fulltext Access 5 Pages 2006
Inhibitory mode of 2-acetoxyphenyl alkyl sulfides against COX-1 and COX-2: QSAR analyses Fulltext Access 5 Pages 2006
Application of azide–alkyne cycloaddition ‘click chemistry’ for the synthesis of Grb2 SH2 domain-binding macrocycles Fulltext Access 5 Pages 2006
Design and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A Fulltext Access 5 Pages 2006
Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase Fulltext Access 5 Pages 2006
Tetrahydroisoquinoline PPARγ agonists: Design of novel, highly selective non-TZD antihyperglycemic agents Fulltext Access 5 Pages 2006
Toward a rational design of selective multi-trypanosomatid inhibitors: A computational docking study Fulltext Access 5 Pages 2006
Universal polyethylene glycol linkers for attaching receptor ligands to quantum dots Fulltext Access 5 Pages 2006
Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome Fulltext Access 5 Pages 2006
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase Fulltext Access 5 Pages 2006
Validation of an HPLC method for the simultaneous determination of DZ5 and its active metabolite in dog plasma and its pharmacokinetics Fulltext Access 5 Pages 2006
Application of new membrane selective electrodes for the determination of drotaverine hydrochloride in tablets and plasma Fulltext Access 5 Pages 2006
Determination of salbutamol in syrups by capillary electrophoresis with contactless conductivity detection (CE-C4D) Fulltext Access 5 Pages 2006
The application of LC–NMR and LC–MS for the separation and rapid structure elucidation of an unknown impurity in 5-aminosalicylic acid Fulltext Access 5 Pages 2006
A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation Fulltext Access 5 Pages 2006
Determination of desoxyepothilone B in nude mice plasma by liquid–liquid extraction and reversed-phase high-performance liquid chromatography Fulltext Access 5 Pages 2006
HPLC method for simultaneous determination of retinol, α-tocopherol and coenzyme Q10 in human plasma Fulltext Access 5 Pages 2006
Study on warfarin plasma concentration and its correlation with international normalized ratio Fulltext Access 5 Pages 2006
A sensitive LC-ESI-MS method for the determination of indapamide in human plasma: Method and clinical applications Fulltext Access 5 Pages 2006
Isolation and characterization of benazepril unknown impurity by chromatographic and spectroscopic methods Fulltext Access 5 Pages 2006
Determination of metoprolol tartrate in tablets and human urine using flow-injection chemiluminescence method Fulltext Access 5 Pages 2006
Simultaneous determination of lamivudine and stavudine in antiretroviral fixed dose combinations by first derivative spectrophotometry and high performance liquid chromatography Fulltext Access 5 Pages 2006
Stability of amphotericin B and nystatin in antifungal mouthrinses containing sodium hydrogen carbonate Fulltext Access 5 Pages 2006
Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments Fulltext Access 5 Pages 2006
Electrochemical studies of the interaction of the anticancer herbal drug emodin with DNA Fulltext Access 5 Pages 2006
HPLC determination of anethole trithione and its application to pharmacokinetics in rabbits Fulltext Access 5 Pages 2006
Determination of DPPH free radical scavenging activity by reversed-phase HPLC: A sensitive screening method for polyherbal formulations Fulltext Access 5 Pages 2006
HPLC method for analysis of a new 1,4-dihydropyridine: Application to pharmacokinetic study in rabbit Fulltext Access 5 Pages 2006
Direct determination of niflumic acid in a pharmaceutical gel by ATR/FTIR spectroscopy and PLS calibration Fulltext Access 5 Pages 2006
Interference from a glucuronide metabolite in the determination of ramipril and ramiprilat in human plasma and urine by gas chromatography–mass spectrometry Fulltext Access 5 Pages 2006
Liquid chromatography–tandem mass spectrometry method for the quantification of deglymidodrine in human plasma Fulltext Access 5 Pages 2006
Synthesis and preliminary biological evaluation of β-carotene and retinoic acid oxidation products Fulltext Access 5 Pages 2006
Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells Fulltext Access 5 Pages 2006
Inhibitors from the rhizomes of Alpinia officinarum on production of nitric oxide in lipopolysaccharide-activated macrophages and the structural requirements of diarylheptanoids for the activity Fulltext Access 5 Pages 2006
Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: Influence of sex and inhibitors Fulltext Access 5 Pages 2006
Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N′-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim Fulltext Access 5 Pages 2006
Study on the compounds containing 19F and 10B atoms in a single molecule for the application to MRI and BNCT Fulltext Access 5 Pages 2006
Synthesis and antidepressant-like action of stereoisomers of imidobenzenesulfonylaziridines in mice evaluated in the forced swimming test Fulltext Access 5 Pages 2006
Evaluation of mismatch-binding ligands as inhibitors for Rev–RRE interaction Fulltext Access 5 Pages 2006
Synthesis and antimicrobial activity studies of ortho-chlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[b]thiophene series Fulltext Access 5 Pages 2006
Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase Fulltext Access 5 Pages 2006
Structure–activity relationship of wedelolactone analogues: Structural requirements for inhibition of Na+,K+-ATPase and binding to the central benzodiazepine receptor Fulltext Access 5 Pages 2006
2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally modified at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1 Fulltext Access 5 Pages 2006
Hyphenation of ultra performance liquid chromatography (UPLC) with inductively coupled plasma mass spectrometry (ICP-MS) for fast analysis of bromine containing preservatives Fulltext Access 5 Pages 2006
Evaluation of 99mTc(CO)3 complex of 2-methyl-5-nitroimidazole as an agent for targeting tumor hypoxia Fulltext Access 5 Pages 2006
Profiling of medium chain glycerides used in pharmaceutical formulation development by reversed-phase HPLC Fulltext Access 5 Pages 2006
Evaluation of rapamycin chemical stability in volatile-organic solvents by HPLC Fulltext Access 5 Pages 2006
Determination of nelfinavir mesylate as bulk drug and in pharmaceutical dosage form by stability indicating HPLC Fulltext Access 5 Pages 2006
Extraction of berberine from rhizome of Coptis chinensis Franch using supercritical fluid extraction Fulltext Access 5 Pages 2006
Excipient quantitation and drug distribution during formulation optimization Fulltext Access 5 Pages 2006
Optimization of entrapment of metronidazole in amphiphilic β-cyclodextrin nanospheres Fulltext Access 5 Pages 2006
NMR spectroscopic studies of the transacylation reactivity of ibuprofen 1-β-O-acyl glucuronide Fulltext Access 5 Pages 2006
Square-wave adsorptive stripping voltammetric determination of danazol in capsules Fulltext Access 5 Pages 2006
Development and validation of a dissolution test for rabeprazole sodium in coated tablets Fulltext Access 5 Pages 2006
Electrochemical study of lincomycin on a multi-wall carbon nanotubes modified glassy carbon electrode and its determination in tablets Fulltext Access 5 Pages 2006