Probing structure/affinity relationships for the Plasmodium falciparum hexose transporter with glucose derivatives Fulltext Access 5 Pages 2006
CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads Fulltext Access 5 Pages 2006
Design and synthesis of 3-substituted benzamide derivatives as Bcr-Abl kinase inhibitors Fulltext Access 5 Pages 2006
Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3 Fulltext Access 5 Pages 2006
New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity Fulltext Access 5 Pages 2006
Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents Fulltext Access 5 Pages 2006
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR Fulltext Access 5 Pages 2006
Chemiluminescent acridinium-9-carboxamide boronic acid probes: Application to a homogeneous glycated hemoglobin assay Fulltext Access 5 Pages 2006
Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus Fulltext Access 5 Pages 2006
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: Synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells Fulltext Access 5 Pages 2006
Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists Fulltext Access 5 Pages 2006
Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β Fulltext Access 5 Pages 2006
(+)-12α-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens Fulltext Access 5 Pages 2006
Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists Fulltext Access 5 Pages 2006
5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers Fulltext Access 5 Pages 2006
Stimulation on DNA triplet repeat strand slippage synthesis by the designed spirocycles Fulltext Access 5 Pages 2006
Synthesis and structure–activity relationships of novel pyrrolocarbazole lactam analogs as potent and cell-permeable inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) Fulltext Access 5 Pages 2006
Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase Fulltext Access 5 Pages 2006
Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers Fulltext Access 5 Pages 2006
Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists Fulltext Access 5 Pages 2006
Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions Fulltext Access 5 Pages 2006
The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2 Fulltext Access 5 Pages 2006
A novel nicotinic acetylcholine receptor antagonist radioligand for PET studies Fulltext Access 5 Pages 2006
Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase Fulltext Access 5 Pages 2006
Phenolic P2/P3 core motif as thrombin inhibitors-Design, synthesis, and X-ray co-crystal structure Fulltext Access 5 Pages 2006
Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors Fulltext Access 5 Pages 2006
Enhanced FTase activity achieved via piperazine interaction with catalytic zinc Fulltext Access 5 Pages 2006
Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity Fulltext Access 5 Pages 2006
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection Fulltext Access 5 Pages 2006
Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera Fulltext Access 5 Pages 2006
Synthesis and structure–activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors Fulltext Access 5 Pages 2006
Discovery of a potent phenolic N1-benzylidene–pyridinecarboxamidrazone selective against Gram-positive bacteria Fulltext Access 5 Pages 2006
Synthesis and structure–activity relationships of a new series of 2α-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as μ-selective opioid antagonists Fulltext Access 5 Pages 2006
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2′ side chains Fulltext Access 5 Pages 2006
Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands Fulltext Access 5 Pages 2006
Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties Fulltext Access 5 Pages 2006
Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties Fulltext Access 5 Pages 2006
Structure–activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels Fulltext Access 5 Pages 2006
The reversed binding of β-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors Fulltext Access 5 Pages 2006
Novel, potent P2–P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors Fulltext Access 5 Pages 2006
2-((1H-Azol-1-yl)methyl)-N-arylbenzamides: Novel dual inhibitors of VEGFR-1/2 kinases Fulltext Access 5 Pages 2006
3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6 Fulltext Access 5 Pages 2006
p38 MAP kinase inhibitors. Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design Fulltext Access 5 Pages 2006
A novel 99mTc-labeled testosterone derivative as a potential agent for targeting androgen receptors Fulltext Access 5 Pages 2006
Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors Fulltext Access 5 Pages 2006
N′,2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II Fulltext Access 5 Pages 2006
Arylsulfonamides: A study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors Fulltext Access 5 Pages 2006
Synthesis and antiviral activity against tobacco mosaic virus and 3D-QSAR of α-substituted-1,2,3-thiadiazoleacetamides Fulltext Access 5 Pages 2006
Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators Fulltext Access 5 Pages 2006
Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists Fulltext Access 5 Pages 2006
Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands Fulltext Access 5 Pages 2006
Fluorinated and hemifluorinated surfactants derived from maltose: Synthesis and application to handling membrane proteins in aqueous solution Fulltext Access 5 Pages 2006
Synthesis, aerobic cytotoxicity, and radiosensitizing activity of novel 2,4-dinitrophenylamine tethered 5-fluorouracil and hydroxyurea Fulltext Access 5 Pages 2006
Synthesis and study of anti-inflammatory activity of some novel cyclophane amides Fulltext Access 5 Pages 2006
Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt Fulltext Access 5 Pages 2006
Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches Fulltext Access 5 Pages 2006
Synthesis and anti-HIV properties of new hydroxyquinoline–polyamine conjugates on cells infected by HIV-1 LAV and HIV-1 BaL viral strains Fulltext Access 5 Pages 2006
The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck) Fulltext Access 5 Pages 2006
Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides Fulltext Access 5 Pages 2006
Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases Fulltext Access 5 Pages 2006
Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction Fulltext Access 5 Pages 2006
Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs Fulltext Access 5 Pages 2006
A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives Fulltext Access 5 Pages 2006
From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist Fulltext Access 5 Pages 2006
Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase Fulltext Access 5 Pages 2006
Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents Fulltext Access 5 Pages 2006
Kinase-mediated trapping of bi-functional conjugates of paclitaxel or vinblastine with thymidine in cancer cells Fulltext Access 5 Pages 2006
Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines Fulltext Access 5 Pages 2006
Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I Fulltext Access 5 Pages 2006
Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases Fulltext Access 5 Pages 2006
Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure Fulltext Access 5 Pages 2006
Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors Fulltext Access 5 Pages 2006
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase Fulltext Access 5 Pages 2006
Synthesis of 3H-spiro[benzofuran-2,1′-cyclohexane] derivatives from naturally occurring filifolinol and their classical complement pathway inhibitory activity Fulltext Access 5 Pages 2006
Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: Increased receptor specificity and in vivo activity Fulltext Access 5 Pages 2006
Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors Fulltext Access 5 Pages 2006
Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: Optimization of the 4-substituted piperidine Fulltext Access 5 Pages 2006
Structurally diverse 5-substituted pyrimidine nucleosides as inhibitors of Leishmania donovani promastigotes in vitro Fulltext Access 5 Pages 2006
Synthesis, structure, and bioactivity of N′-substituted benzylidene-3,4,5-trimethoxybenzohydrazide and 3-acetyl-2-substituted phenyl-5-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1,3,4-oxadiazole derivatives Fulltext Access 5 Pages 2006
Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities Fulltext Access 5 Pages 2006
Discovery of potent inhibitors of pseudomonal quorum sensing via pharmacophore modeling and in silico screening Fulltext Access 5 Pages 2006
Potent antagonists of the Kv1.5 potassium channel: Synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides Fulltext Access 5 Pages 2006
Synthesis and structure-activity relationships of 3-phenyl-2-propenamides as inhibitors of glycogen phosphorylase a Fulltext Access 5 Pages 2006
Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: Synthesis and biological evaluation as potential antibacterial and antifungal agents Fulltext Access 5 Pages 2006
Discovery of small molecule inhibitors of integrin αvβ3 through structure-based virtual screening Fulltext Access 5 Pages 2006
Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers Fulltext Access 5 Pages 2006
Effects of α-substitutions on structure and biological activity of anticancer chalcones Fulltext Access 5 Pages 2006