Keywords: freeze-drying/lyophilization; lyophilization; drying; proteins; stability; excipients; solid state; monoclonal antibody; glass; CFD; conventional freeze-drying; HPW; highly purified water; HP-β-CD; 2-Hydroxypropyl-β-cyclodextrin; mAb; monoclonal antibod
مقالات ISI (ترجمه نشده)
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Keywords: GB; Glibenclamide; αCD; α-cyclodextrin; βCD; β-cyclodextrin; HP-βCD; 2-hydroxypropyl-β-cyclodextrin; RM-βCD; randomly methyl-β-cyclodextrin; γCD; γ-cyclodextrin; DLS; dynamic light scattering; TEM; transmission electron microscopy; CE; complexat
Simultaneous separation and determination of four uncaria alkaloids by capillary electrophoresis using dual cyclodextrin system
Keywords: HP-β-CD; 2-hydroxypropyl-β-cyclodextrin; ED-β-CD; mono-(6-ethylenediamine-6-deoxy)-β-cyclodextrin; UR; Uncaria rhynchophylla (Miq) Miq. ex Havil; RC; rhynchophylline; IRC; isorhynchophylline; CN; corynoxeine; ICN; isocorynoxeine; BGE; background elect
Keywords: Nanoparticle; Rebamipide; Particle size; Ophthalmic dispersion; Cornea; Abs; absorbance; BAC; benzalkonium chloride; CA; commercially available; HCE-T; human corneal epithelial cell line; HPβCD; 2-hydroxypropyl-β-cyclodextrin; MC; methylcellulose; OLETF
Keywords: MetAP; methionine aminopeptidase; MetAMC; methionyl-7-amino-4-methylcoumarin; HP-β-CD; 2-hydroxypropyl-β-cyclodextrin; Substrate bridging; Cyclodextrin; Methionine aminopeptidase; Inhibition; Cyclodextrin-substrate complex; Molecular modeling;
Role of 6-O-α-maltosyl-β-cyclodextrin in lysosomal cholesterol deprivation in Npc1-deficient Chinese hamster ovary cells
Keywords: 6-O-α-maltosyl-β-cyclodextrin (Mal-βCD); Npc1-deficient cells; Lysosomal unesterified cholesterol; Cholesterol/efflux; Endocytosis; Liquid chromatography-mass spectrometry; βCD; β-cyclodextrin; CHO; Chinese hamster ovary; DAOS; (hydroxy-3-sulfopropyl
Spectral and theoretical study on complexation of sulfamethoxazole with β- and HPβ-cyclodextrins in binary and ternary systems
Keywords: Sulfamethaxazole; Inclusion complex; β-Cyclodextrin; Ternary complex; 2-Hydroxypropyl-β-cyclodextrin; Molecular dynamics;
Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes
Keywords: cyclodextrin; 2-hydroxypropyl-β-cyclodextrin; COSY; correlation spectroscopy; 7DHP; 7-dehydropregnenolone; 7DHC; 7-dehydrocholesterol; HSQC; heteronuclear single quantum correlation; HMBC; heteronuclear multiple bond correlation; pD; pregcalciferol; TOCS
A water-based topical Chinese traditional medicine (Zicao) for wound healing developed using 2-hydroxypropyl-β-cyclodextrin
Keywords: Traditional chinese medicine; 2-Hydroxypropyl-β-cyclodextrin; Zicao; Wound healing; Water soluble;
CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites
Keywords: CYP; cytochrome P450; 7DHC; 7-dehydrocholesterol; 20,22(OH)2L3; 20,22-dihydroxylumisterol3; HP-β-CD; 2-hydroxypropyl-β-cyclodextrin; 25(OH)D3; 25-hydroxyvitamin D3; 22(OH)L3; 22-hydroxylumisterol3; 24(OH)L3; 24-hydroxylumisterol3; 25(OH)L3; 25-hydroxylu
Redox-stimuli-responsive drug delivery systems with supramolecular ferrocenyl-containing polymers for controlled release
Keywords: A549; A549 lung cancer cells; AAO; anodized alumina substrates; Ad; adamantane; ALMA; allyl methacrylate; ATRP; atom transfer radical polymerization; AuNPs; gold nanoparticles; CAC; critical aggregation concentration; CB[7]; cucurbituril; β-CD; β-cyclod
Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3
Keywords: 1,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 25(OH)D3; 25-hydroxyvitamin D3; 20(OH)D3; 20S-hydroxyvitamin D3; 20,25(OH)2D3; 20S,25-dihydroxyvitamin D3; 20,23(OH)2D3; 20S,23S-dihydroxyvitamin D3; 1,20,25(OH)3D3; 1α,20S,25-trihydroxyvitamin D3; CYP; cytochrome
Experimental and molecular modeling investigations of inclusion complexes of imazapyr with 2-hydroxypropyl(β/γ) cyclodextrin
Keywords: Imazapyr; Herbicides; 2-Hydroxypropyl-β-cyclodextrin; 2-hydroxypropyl-γ-cyclodextrin; Inclusion complex; Molecular dynamics;
CYP260B1 acts as 9α-hydroxylase for 11-deoxycorticosterone
Keywords: AdR; adrenodoxin reductase; Adx4-108; adrenodoxin (truncated form); P450; cytochrome P450; DOC; 11-deoxycorticosterone; HP-β-CD; 2-hydroxypropyl-β-cyclodextrin; T224A mutant; CYP260B1-T224A; Steroids; 11-Deoxycorticosterone; CYP260B1; Sorangium cellul
Development and pharmaceutical evaluation of the anticancer Anthrafuran/Cavitron complex, a prototypic parenteral drug formulation
Keywords: Anthra[2,3-b]furan; 2-Hydroxypropyl-β-cyclodextrin; Drug formulation; Anticancer activity; Acute toxicity;
Supramolecular structure of glibenclamide and β-cyclodextrins complexes
Keywords: GB; Glibenclamide; βCD; β-cyclodextrin; HPβCD; 2-hydroxypropyl-β-cyclodextrin; RMβCD; randomly methyl-β-cyclodextrin; KN; kneaded; ECOEtOH; coevaporated in ethanol/water; CONH3; coevaporated in ammonia water; FD; freeze-dried; PM; physical mixture;
Synthesis, characterization, in vitro SAR and in vivo evaluation of N,Nâ²bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC
Keywords: NCI; National Cancer Institute; IC50; inhibitory concentration 50%; NSCLC; non-small cell lung cancer; IC23; 4,5-dichloro-1,3-bis(naphthalen-2-ylmethyl)imidazolium bromide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; CD; cyclodextri
Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease
Keywords: CDX; 2-hydroxypropyl-β-cyclodextrin; GCS; glucosylceramide synthase; GSH-EE; GSH ethyl ester; mGSH; mitochondrial GSH; NAC; N-acetylcysteine; NPC; Niemann Pick type C disease; SMS; sphingomyelin synthase; Ceramide; Sphingolipids, Mitochondrial GSH; Cereb
Inclusion complex of antiasthmatic compound with 2-hydroxypropyl-β-cyclodextrin: Preparation and physicochemical properties
Keywords: Antiasthmatic compound; 2-Hydroxypropyl-β-cyclodextrin; Inclusion complex; Improved solubility; UV-vis; FTIR; XPRD;
Characterization and cytotoxicity of PLGA nanoparticles loaded with formononetin cyclodextrin complex
Keywords: Formononetin; 2-Hydroxypropyl-β-cyclodextrin; Inclusion complex; PLGA nanoparticles; Cytotoxicity;
Physicochemical characteristics of the inclusion complexes of biologically active compounds with 2-hydroxypropyl-β-cyclodextrin
Keywords: Biologically active compounds; 2-hydroxypropyl-β-cyclodextrin; Inclusion complex; Improved solubility; Characterization;
Structure-property relationship for in vitro siRNA delivery performance of cationic 2-hydroxypropyl-β-cyclodextrin: PEG-PPG-PEG polyrotaxane vectors
Keywords: Gene silencing; siRNA; Polyrotaxane; β-Cyclodextrin; Cryoelectron microscopy; Small angle X-ray scattering; PO; polypropylene alcohol; EO; polyethylene alcohol; HPβCD; 2-hydroxypropyl-β-cyclodextrin; PR+; cationic polyrotaxanes; L2K; Lipofectamine® 20
Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis
Keywords: MS; multiple sclerosis; CNS; central nervous system; S1P; sphingosine 1-phosphate; BBB; blood-brain barrier; OPC; oligodendrocyte progenitor cell; Shh; sonic hedgehog; Smo; smoothened; EAE; experimental autoimmune encephalomyelitis; PLP; myelin proteoli
Melatonin/HPβCD complex: Microwave synthesis, integration with chitosan scaffolds and inhibitory effects on MG-63CELLS
Keywords: 2-Hydroxypropyl-β-cyclodextrin; Melatonin; Microwave; Inclusion complex;
Inhibitory effect of Angelica sinensis extract in the presence of 2-hydroxypropyl-β-cyclodextrin
Keywords: Angelica sinensis; 2-Hydroxypropyl-β-cyclodextrin; Traditional Chinese medicine; Complex; Hepatoma cell;
Lumisterol is metabolized by CYP11A1: Discovery of a new pathway
Keywords: cyclodextrin; 2-hydroxypropyl-β-cyclodextrin; 7-DHC; 7-dehydrocholesterol; L3; lumisterol3; 20(OH)L3; 20-hydroxylumisterol3; 22(OH)L3; 22-hydroxylumisterol3; 24(OH)L3; 24-hydroxylumisterol3; 20,22(OH)2L3; 20,22-dihydroxylumisterol3; pL; pregnalumisterol;
The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors
Keywords: ERK; extracellular signal-regulated kinase; hERG; human ether-a-go-go related gene; HPCD; 2-hydroxypropyl-β-cyclodextrin; LYSA; lyophilized solubility assay; MEK; mitogen-activated protein kinase; PAMPA; parallel artificial membrane permeability assay; P
Substitution of membrane cholesterol with β-sitosterol promotes nonamyloidogenic cleavage of endogenous amyloid precursor protein
Keywords: Aβ; beta amyloid; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE-1; β-secretase-1; BS; β-sitosterol; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; DMEM; Dulbecco's Minimum Essential Medium; ELISA; enzyme-linked im
Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents
Keywords: Adx; adrenodoxin; Adr; adrenodoxin reductase; DLPC; dilauroylglycerol-3-phosphatidylcholine; HPCD; 2-hydroxypropyl-β-cyclodextrin; KPi; potassium phosphate; PL; phospholipid; Cytochrome P450; CYP11A1; CYP46A1; Inhibition; Activation; Drug target;
Enhancement of rhubarb extract solubility and bioactivity by 2-hydroxypropyl-β-cyclodextrin
Keywords: Rhubarb; 2-Hydroxypropyl-β-cyclodextrin; Traditional Chinese medicine; Complex; Hepatoma cell;
Development of Imiquimod-Loaded Mucoadhesive Films for Oral Dysplasia
Keywords: oral cancer; mucosal drug delivery; biomaterials; polyvinylpyrrolidone; carboxymethylcellulose; 2-hydroxypropyl-β-cyclodextrin; controlled release/delivery; polymeric drug carrier; solubility;
Studies on the Preparation, Characterization, and Solubility of 2-HP-β-Cyclodextrin-Meclizine HCI Inclusion Complexes
Keywords: 2-Hydroxypropyl-β-cyclodextrin; β-cyclodextrin; co-precipitation method; kneading method; phase solubility profile; Meclizine HCl;
Effects of an antimalarial quinazoline derivative on human erythrocytes and on cell membrane molecular models
Keywords: SEM; scanning electron microscopy; IUM; isolated unsealed erythrocyte membrane; RBCS; red blood cell suspensions; LUV; large unilamellar vesicles; DMPC; dimyristoylphosphatidylcholine; DMPE; dimyristoylphosphatidylethanolamine; r; fluorescence anisotropy;
Photodynamic therapy with zinc-tetra(p-sulfophenyl)porphyrin bound to cyclodextrin induces single strand breaks of cellular DNA in G361 melanoma cells
Keywords: PDT; photodynamic therapy; ZnTPPS4; zinc complex of meso-tetrakis(4-sulphonatophenyl)porphyrin; hpβCD; 2-hydroxypropyl-β-cyclodextrin; CD; cyclodextrin; Sensitizers; Light; Phototoxicity; Comet assay;
Simultaneous quantification of different cyclodextrins and Gantrez by HPLC with evaporative light scattering detection
Keywords: β-Cyclodextrin; 2-Hydroxypropyl-β-cyclodextrin; HPLC; ELSD; Nanoparticles; Poly(methyl vinyl ether-co-maleic anhydride);