کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2485031 | 1114343 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of Imiquimod-Loaded Mucoadhesive Films for Oral Dysplasia
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کلمات کلیدی
2-hydroxypropyl-β-cyclodextrinSolubility - انحلال پذیریBiomaterials - بیومتریال، بیومواد Mucosal drug delivery - تحویل داروی تخمدانPolymeric drug carrier - حامل مواد مخدر پلیمریOral cancer - سرطان دهانpolyvinylpyrrolidone - پلی وینیل پیرولیدونcarboxymethylcellulose - کربوکسی متیل سلولزControlled release/delivery - کنترل انتشار / تحویل
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development of Imiquimod-Loaded Mucoadhesive Films for Oral Dysplasia Development of Imiquimod-Loaded Mucoadhesive Films for Oral Dysplasia](/preview/png/2485031.png)
چکیده انگلیسی
Oral squamous dysplasia, which can usually be readily visualized as leukoplakia during an oral examination and confirmed by histology, is often considered a premalignant condition. Current treatments, however, focus on the final stages of disease, and treatments such as surgery can lead to postoperative disabilities. Hence, this study was designed to develop a noninvasive, mucoadhesive drug delivery system loaded with an immune response modifier, imiquimod, as a treatment for precancerous dysplastic lesions. Blends of polyvinylpyrrolidone and carboxymethylcellulose were used to prepare mucoadhesive films that were backed with poly(ethylene-co-vinyl acetate). Because of the hydrophobic nature of imiquimod, four loading methods (sonication, linoleic acid, 2-hydroxypropyl-β-cyclodextrin, and acetate buffer) were compared. The formation of imiquimod-cyclodextrin complexes and their solubility was studied by differential scanning calorimetry and phase solubility studies. All films achieved sustained release of drug for 3 h except those prepared by linoleic acid. The high solubility of imiquimod in acetate buffer facilitated high loading capacity and greater release (68%) of drug than did the other formulations (approximately 40%). In summary, a noninvasive and local approach with the potential to treat precancerous lesions may be achieved by this described mucoadhesive drug delivery system. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:593-603, 2013
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 2, February 2013, Pages 593-603
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 2, February 2013, Pages 593-603
نویسندگان
Sandeep K. Ramineni, Larry L. Jr., Thomas D. Dziubla, David A. Puleo,