کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5409019 | 1506534 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inclusion complex of antiasthmatic compound with 2-hydroxypropyl-β-cyclodextrin: Preparation and physicochemical properties
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inclusion complex of antiasthmatic compound with 2-hydroxypropyl-β-cyclodextrin: Preparation and physicochemical properties Inclusion complex of antiasthmatic compound with 2-hydroxypropyl-β-cyclodextrin: Preparation and physicochemical properties](/preview/png/5409019.png)
چکیده انگلیسی
This work aims at obtaining 2-hydroxypropyl-β-cyclodextrin inclusion complex with an original antiasthmatic compound in buffer solution and solid state with higher solubility and, hence, bioavailability. The compound solubility with different 2-hydroxypropyl-β-cyclodextrin concentrations has been studied by the phase solubility method. The linearity of the phase solubility diagrams is classified as an AL type and indicates the formation of inclusion complexes with 1:1 stoichiometry. The complex stoichiometry has been confirmed by the Job's method. The solubility of the studied compound in buffer has been considerably increased by complexation with 2-hydroxypropyl-β-cyclodextrin. Complexation stability constants and thermodynamic parameters have been calculated. The obtained inclusion complexes in solid state have been studied by the differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The kinetic characteristics of dissolution for the supramolecular complex have been obtained.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 237, July 2017, Pages 185-192
Journal: Journal of Molecular Liquids - Volume 237, July 2017, Pages 185-192
نویسندگان
Marina V. Ol'khovich, Angelica V. Sharapova, German L. Perlovich, Sofia Ya. Skachilova, Nikolai K. Zheltukhin,