Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; 27-HC; 27-hydroxycholesterol; ER; estrogen receptor; CYP27A1; cytochrome P450, family 27, subfamily A, polypeptide 1; LXR; liver X receptor; BRCA1 and BRCA2; Breast cancer 1 and 2; LDL; low density lipoprotein; HDL; high density lipoprotein; ApoE; apolipo
مقالات ISI 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز (ترجمه نشده)
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Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Acadl; acyl-CoA dehydrogenase, long chain; Acadvl; acyl-CoA dehydrogenase, very long chain; Acaca; acetyl-CoA carboxylase alpha; Abcb11; ATP binding cassette subfamily B member 11; Abcg5; ATP binding cassette subfamily G member 5; Abcg8; ATP binding casse
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Rare disease; Sterol; Homeostasis; Sterol regulatory element binding protein-2; ABCG8; ATP-binding cassette sub-family G member 8; SREBP-2; Sterol regulatory element-binding protein 2; LDL; low-density lipoprotein; HMGCR; 3-Hydroxy-3-Methylglutaryl-CoA re
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; ACSVL3; acyl-coA synthetase VL3; ALDH1; aldehyde dehydrogenase; ALDOA; aldolase A; ALDOC; aldolase C; AMPK; 5â² AMP-activated protein kinase; ASNS; asparagine synthetase; BTICs; brain tumor initiating cells; 3-BrOP; 3-bromo-2-oxopropionate-1-propyl ester
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; FTase; farnesyl transferase; GGTase; geranylgeranyl transferase; Statin toxicity; Prenylation; Cholesterol; HMG COA;
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; AD; Alzheimer's disease; BBB; blood-brain barrier; CE; cholesterol esterase; FC; free cholesterol; HMG-CR; 3-hydroxy-3-methylglutaryl-CoA reductase; LXR-α; liver X receptor-α; LDL; low-density lipoprotein; LDLR; low-density lipoprotein receptor; LXR
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; CYP7A1; cytochrome P450 family 7 subfamily A polypeptide 1; FXRα; farnesoid X receptor α; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; LDLR; low density lipoprotein receptor; PCSK9; proprotein convertase subtilisin/kexin type 9; SREBP2; sterol regul
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; FPP; farnesyl pyrophosphate; FPPS; farnesyl pyrophosphate synthase; GPP; geranyl diphosphate; HMG-CoA reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; IPP; isopentenyl diphosphate; MDD; mevalonate 5-diphosphate decarboxylase, also known as mevalonate
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; ROS; reactive oxygen species; NR; nuclear receptor; FA; fatty acid; TAG; triacylglycerol; MCD; malonyl-CoA decarboxylase; ACC; acetyl-CoA carboxylase; FAS; fatty acid synthase; SCD1; stearoyl-CoA desaturase-1; G-3-P; glycerol 3-phosphate; CPT-1; carnitine
Mining Ferula gummosa transcriptome to identify miRNAs involved in the regulation and biosynthesis of terpenes
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; bp; base pair(s); RNA-seq; ribonucleic acid sequencing; KEGG; The Kyoto Encyclopedia of Genes and Genome; BLAST; basic local alignment search tool; TF; transcription factor; TP; terpene synthesis; GO; gene ontology; E-value; expectation value; MVA; mevalo
Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; AACT; acetoacetyl-CoA acyltransferase; DS; dammarenediol-II synthase; DXPS; 1-deoxy-d-xylulose 5-phosphate synthase; DXPR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPS; farnesyl pyrophosphate synthase; FPP; farnesyl diphosphate; GDPS; gerenyl diph
Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Cholesterol metabolism; Lipoproteins; Liver; Transcription; Dyslipidemia; ABCA1; ATP-binding cassette transporter A1; ACAT2; acyl-Coenzyme A:cholesterol acyltransferase 2; apo; apolipoprotein; CYP7A1; cholesterol 7α-hydroxylase; HMGCR; 3-hydroxy-3-methyl
Part A: Temporal and dose-dependent transcriptional responses in the liver of fathead minnows following short term exposure to the polycyclic aromatic hydrocarbon phenanthrene
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; SREBF1; sterol regulatory element binding transcription factor 1; FASN; fatty acid synthase; HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; ACACA; acetyl-CoA carboxylase alpha; CYB5A; cytochrome b5 type A (microsomal); SLC27A4; solute carrier family
Part B: Morphometric and transcriptomic responses to sub-chronic exposure to the polycyclic aromatic hydrocarbon phenanthrene in the fathead minnow (Pimephales promelas)
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; PNPLA2; patatin-like phospholipase domain containing 2; APOE; apolipoprotein E; NPC1; Niemann-Pick disease, type C1; LCAT; lecithin-cholesterol acyltransferase; DGAT1; diacylglycerol O-acyltransferase 1; LRP1; low density lipoprotein-related protein 1 (al
Lysophosphatidylcholine induces expression of genes involved in cholesterol biosynthesis in THP-1 derived macrophages
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; LPC; lysophosphatidylcholine; PCA; principal component analysis; FFA; free fatty acids; DMSO; dimethyl sulfoxide; FPKM; fragments per kilobase of transcript per million fragments mapped; RT-PCR; reverse transcription polymerase chain reaction; KEGG; Kyoto
Prenatal caffeine ingestion induces long-term alterations in scavenger receptor class B type I expression and glucocorticoid synthesis in adult male offspring rat adrenals
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Prenatal caffeine ingestion (PCI); Intrauterine growth retardation (IUGR); Scavenger receptor class B type I (SR-BI); Glucocorticoids; Cholesterol supply; Adrenal; ACTH; adrenocorticotropic hormone; CE; cholesteryl esters; GAPDH; glyceraldehyde phosphate
The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; GFAP; glial fibrillary acidic protein; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase-1; PSD95; postsynaptic density protein 95; miRNA; astrocytes; cholesterol; aging; memory;
Maternal fructose induces gender-dependent changes in both LXRα promoter methylation and cholesterol metabolism in progeny
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; RCT; Reverse cholesterol transport; LXRα; Liver X-receptor alpha; CpG islands; CG-dinucleotide-rich regions in the gene promoter; HDL; High-density lipoproteins; PPAR; Peroxisome proliferator-activated receptor; SRB-1; Scavenger Receptor class B, member
Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; AD; Alzheimer disease; Aβ; β-amyloid; ADAM10; A disintegrin and metalloproteinase domain-containing protein 10/α-secretase (brain); APP; Amyloid Protein Precursor; APOE ε4; Apolipoprotein, allele epsilon4; BACE1; beta-site amyloid precursor protein cl
Complex lipid metabolic remodeling is required for efficient hepatitis C virus replication
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; AA; arachidonic acid; ALA; α-linolenic acid; CD81; cluster of differentiation 81; CE; cholesterol ester; Cer; ceramides; Chol; cholesterol; CoA; coenzyme A; cPLA2; cytosolic phospholipases A2; DAG; diglycerides; DHA; docosahexaenoic acid; DMV; double-mem
Short communicationPhosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; 7DHC; 7-dehydrocholesterol; AMPK; AMP-activated protein kinase; CaMKII; calmodulin-dependent kinase II; CHO; Chinese hamster ovary; CKI; casein kinase I; DHCR7; 7-dehydrocholesterol reductase; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; PBGD; porphob
The molecular basis of superficial scald development related to ethylene perception and α-farnesene metabolism in 'Wujiuxiang' pear
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; 1-MCP; 1-methylcyclopropene; CTols; conjugated trienols; HMGR; 3-hydroxy-3-methylglutaryl-CoA reductase; AFS; α-farnesene synthase; GPX; glutathione peroxidase; GST; glutathione S-transferase; CT; conjugated triene; ROS; reactive oxygen species; SOD; sup
Thyroid stimulating hormone exhibits the impact on LDLR/LDL-c via up-regulating hepatic PCSK9 expression
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; SCH; subclinical hypothyroidism; TC; total cholesterol; LDL-c; low-density lipoprotein cholesterol; TSH; thyroid stimulating hormone; TSHR; thyroid stimulating hormone receptor; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; PCSK9; proprotein convertase
Coenzyme Q10 protects against statin-induced myotoxicity in zebrafish larvae (Danio rerio)
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; ATV; Atorvastatin; EM; embryo medium; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; hpf; hours post-fertilization; PTS; polyoxyethanyl-α-tocopheryl sebacate; Zebrafish; Larvae; CoQ10; Myotoxicity; Muscle atrophy; Mitochondria;
Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; CYP; cytochrome P450; EMT; epithelial-to-mesenchymal transition; Cx43; connexin 43; GJIC; gap junction intercellular communication; HMGCoA reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; NHE1; Na
HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the late stage*
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; hpi; hours post infection; JNK1/2; Jun NH(2)-terminal kinase 1/2; kb; kilobase; MβCD; methyl-β-cyclodextrin; PBS; phosphate-buffered saline; PCR; polymer
Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; 24S-OHC; 24(S)-hydroxycholesterol; Apoe; apolipoprotein E; CNS; central nervous system; Cyp27a1; cholesterol 27-hydroxylase; Cyp46a1; cholesterol 24-hydroxylase; Hmgcr; 3-hydroxy-3-methylglutaryl-CoA reductase; Mecp2; methyl CpG-binding protein 2; SC4mol;
Research paperHMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; GC; gastric cancer; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; ATCC; American Type Culture Collection; FBS; fetal bovine serum; GFP; green fluorescence protein; PBS; phosphate-buffered saline; Gastric cancer; HMGCR; Cell growth and migration; Hedgeh
DHCR7: A vital enzyme switch between cholesterol and vitamin D production
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; 7DHC; 7-dehydrocholesterol; AEBS; antiestrogen binding site; DHCR7; 7-dehydrocholesterol reductase; DHCR14; Î14-sterol reductase; DHCR24; 24-dehydrocholesterol reductase; EBP; emopamil binding protein; Hh; Hedgehog; HMGCR; 3-hydroxy-3-methylglutaryl-CoA
Quantitative metabolome, proteome and transcriptome analysis of midgut and fat body tissues in the mountain pine beetle, Dendroctonus ponderosae Hopkins, and insights into pheromone biosynthesis
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Cytochrome P450; Mevalonate pathway; Midgut; Fat bodies; AACT; acetoacetyl-CoA thiolase; GO; gene ontology; GPPS/FPPS; geranyl diphosphate synthase/farnesyl diphosphate synthase; GGPPS; geranylgeranyl diphosphate synthase; HMG-R; 3-hydroxy-3-methylglutary
Production of dammarane-type sapogenins in rice by expressing the dammarenediol-II synthase gene from Panax ginseng C.A. Mey
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; DS; Dammarenediol-II synthase; T-DNA; Transfer-DNA; HPLC; High performance liquid chromatography; PPD; 20 (S)-Protopanaxadiol; PPT; 20 (S)-Protopanaxatriol; DAD; Dammarenediol-II; ESI; Electrospray ionization; EIC; Extracted ion chromatogram; PSY; Phyto
The low temperature induced rate of 3-hydroxy-3-methylglutaryl-CoA reductase in Parthenium argentatum Gray limits the theoretical rate of rubber formation
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Partheniumar gentatum Gray; Chihuahuan Desert; 3-Hydroxy-3-methylglutaryl-CoA reductase; Rubber transferase; Rubber induction; Quantitative rubber biosynthesis; HMGS; 3-hydroxy-3-methylglutaryl-CoA synthase; HMGR; 3-hydroxy-3-methylglutaryl-CoA reductase;
Partial cloning, tissue distribution and effects of epigallocatechin gallate on hepatic 3-hydroxy-3-methylglutaryl-CoA reductase mRNA transcripts in goldfish (Carassius auratus)
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; ABCA1; ATP-binding cassette transporter A1; BW; body weight; CYP7A1; cholesterol 7alpha-hydroxylase; EGCG; Epigallocatechin gallate; HMGCoAR; 3-hydroxy-3-methylglutaryl-CoA reductase; HMGCoAR-a; 3-hydroxy-3-methylglutaryl-CoA reductase isoform A; HMGCoAR-
Multiple genes of mevalonate and non-mevalonate pathways contribute to high aconites content in an endangered medicinal herb, Aconitum heterophyllum Wall
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; HMGS; 3-hydroxy-3-methylglutaryl-CoA synthase; HMGR; 3-hydroxy-3-methylglutaryl-CoA reductase; PMK; phosphomevalonate kinase; IPPI; isopentenyl pyrophosphate isomerase; DXPS; 1-deoxy-d-xylulose 5-phosphate synthase; ISPD; 2-C-methylerythritol 4-phosphate
Cholesterol biosynthesis and ER stress in peroxisome deficiency
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Peroxisomes; Cholesterol; Isoprenoid; Pex2; SREBP-2; ER stress; Integrated stress response; Unfolded protein response; Zellweger syndrome; ACAT; acetoacetyl-CoA thiolase; ATF; activating transcription factor; BA; bile acid; CHOP; C/EBP homologous protein;
eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; TERT; telomerase reverse transcriptase; mTOR; mechanistic target of rapamycin; S6K; p70 S6 kinase; 4E-BP1; 4E-binding protein 1; eIF4; eukaryotic initiation factor 4; PI3K; phosphoinositide 3-kinase; CHAPS; 3-[(3-Cholamidopropyl)dimethylammonio]-l-propane
Cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza Bge. f. alba
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Salvia miltiorrhiza Bge. f. alba; SmHDR1; Expression profiling; Tanshinones; Hairy root; CTAB; cetyltrimethylammonium bromide; DMAPP; dimethylallyl diphosphate; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synt
Contents of therapeutic metabolites in Swertia chirayita correlate with the expression profiles of multiple genes in corresponding biosynthesis pathways
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; 7-DLGT; 7-deoxyloganetic acid glucosyl transferase; 8-HGO; 8-hydroxygeraniol oxidoreductase; AAC; acetyl-CoA carboxylase; AACT; acetoacetyl-CoA thiolase; ADH; arogenate dehydrogenase; ADT; prephenate dehydratase; C3H; p-coumarate 3-hydroxylase; C4H; trans
Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Polyalthia longifolia var. pendula; Clerodane diterpene; Lipid lowering activity; 3-Hydroxy-3-methylglutaryl-CoA reductase; Hamsters
Implication of HMGR in homeostasis of sequestered and de novo produced precursors of the iridoid biosynthesis in leaf beetle larvae
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Leaf beetle; Chemical defense; Iridoids; 3-Hydroxy-3-methylglutaryl-CoA reductase; 8-Hydroxygeraniol; Fat body; Sequestration
Diosgenin, a naturally occurring furostanol saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Colon cancer; HCT-116 cells; 3-Hydroxy-3-methylglutaryl-CoA reductase; Diosgenin; Saponin; Cytotoxicity; Apoptosis
Iridoid biosynthesis in Chrysomelina larvae: Fat body produces early terpenoid precursors
Keywords: 3-هیدروکسی-3-methylglutaryl-CoA ردوکتاز; Leaf beetle; Chemical defense; Iridoids; 3-hydroxy-3-methylglutaryl-CoA reductase; Isoprenyl diphosphate synthase; Fat body;