کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8358867 | 1542166 | 2016 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DHCR7: A vital enzyme switch between cholesterol and vitamin D production
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
AEBSDHCR77-dehydrocholesterol reductase7-DehydrocholesterolDHCR24EBPSRESREBP-2HMGCRLBRNADPHUVB7DHCSSDSLOS24-dehydrocholesterol reductase - 24-دی هیدروکلوسترول ردوکتاز3-hydroxy-3-methylglutaryl-CoA reductase - 3-هیدروکسی-3-methylglutaryl-CoA ردوکتازultraviolet B - اشعه ماوراء بنفش BHedgehog - جوجهتیغی، خارپشتsterol-sensing domain - دامنه سنجش استرولtransmembrane domain - دامنه فرابنفشantiestrogen binding site - سایت اتصال دهنده آنتی استروژنSmith-Lemli-Opitz Syndrome - سمیت اسمیت-لملی-اپیتسnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphateVitamin D3 - ویتامین D3، کوله کلسیفرولSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدcholesterol - کلسترولLamin B receptor - گیرنده Lamin B
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: DHCR7: A vital enzyme switch between cholesterol and vitamin D production DHCR7: A vital enzyme switch between cholesterol and vitamin D production](/preview/png/8358867.png)
چکیده انگلیسی
The conversion of 7-dehydrocholesterol to cholesterol, the final step of cholesterol synthesis in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol reductase (DHCR7). Homozygous or compound heterozygous mutations in DHCR7 lead to the developmental disease Smith-Lemli-Opitz syndrome, which can also result in fetal mortality, highlighting the importance of this enzyme in human development and survival. Besides serving as a substrate for DHCR7, 7-dehydrocholesterol is also a precursor of vitamin D via the action of ultraviolet light on the skin. Thus, DHCR7 exerts complex biological effects, involved in both cholesterol and vitamin D production. Indeed, we argue that DHCR7 can act as a switch between cholesterol and vitamin D synthesis. This review summarizes current knowledge about the critical enzyme DHCR7, highlighting recent findings regarding its structure, transcriptional and post-transcriptional regulation, and its links to vitamin D synthesis. Greater understanding about DHCR7 function, regulation and its place within cellular metabolism will provide important insights into its biological roles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 64, October 2016, Pages 138-151
Journal: Progress in Lipid Research - Volume 64, October 2016, Pages 138-151
نویسندگان
Anika V. Prabhu, Winnie Luu, Dianfan Li, Laura J. Sharpe, Andrew J. Brown,