Gait analysis in three different 6-hydroxydopamine rat models of Parkinson's disease
Keywords: Parkinson's disease; Gait; CatWalk; 6-Hydroxydopamine; Neurochemical correlation;
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Increased neurotrophic factor levels in ventral mesencephalic cultures do not explain the protective effect of osteopontin and the synthetic 15-mer RGD domain against MPPÂ + toxicity
Keywords: 6-OHDA; 6-hydroxydopamine; BDNF; brain-derived neurotrophic factor; ED-1; ectodermal dysplasia 1; GDNF; glial-derived neurotrophic factor; GFAP; glial fibrillary acidic protein; MPPÂ +; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahyd
Other MethodOriginal ArticleEffects of Stochastic Vestibular Galvanic Stimulation and LDOPA on Balance and Motor Symptoms in Patients With Parkinson's Disease
Keywords: Parkinson's disease; Vestibular stimulation; Levodopa; Posture; 6-OHDA; 6-hydroxydopamine; COP; center of pressure; PLM; posturo-locomotor-manual test; MT; movement time; SR; stochastic resonance; STN-DBS; subthalamic nucleus deep brain stimulation; SVS;
Alpha-linolenic acid suppresses dopaminergic neurodegeneration induced by 6-OHDA in C. elegans
Keywords: 6-Hydroxydopamine; Alpha linolenic acid (ALA); C. elegans; Dopamine; Neurodegeneration; Lifespan;
Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson's disease
Keywords: 6-OHDA; 6-hydroxydopamine; AIMs; abnormal involuntary movements; L-DOPA; L-3,4-dihydroxyphenylalanine; LID; L-DOPA-induced dyskinesia; MPTP; 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine; PD; Parkinson's disease; SERT; serotonin transporter; SSRIs; selec
Intranasal administration of glial-derived neurotrophic factor (GDNF) rapidly and significantly increases whole-brain GDNF level in rats
Keywords: 6-OHDA; 6-hydroxydopamine; BBB; blood-brain barrier; BSA; bovine serum albumin; ELISA; enzyme-linked immunosorbent assay; GDNF; glial-derived neurotrophic factor; PBS; phosphate-buffered saline; PD; Parkinson's disease; SN; substantia nigra; intranasa
The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions
Keywords: ANOVA; analysis of variance; α-CtxMII; α-conotoxinMII; DAT; dopamine transporter; nAChRs; nicotinic receptors; 6-OHDA; 6-hydroxydopamine; 125I-RTI-121; 125I-3β-(4-iodophenyl)tropane-2β-carboxylic acid isopropyl ester; ABT-107; DMXB; Neuroprotection; N
Disturbance of sensorimotor filtering in the 6-OHDA rodent model of Parkinson's disease
Keywords: 6-Hydroxydopamine; Parkinson's disease model; Basal ganglia; L-DOPA; Prepulse inhibition;
Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways
Keywords: 6-OHDA; 6-hydroxydopamine; Akt; anti-apoptotic kinase; CNS; central nervous system; DA; dopaminergic; DMSO; dimethyl sulfoxide; dpf; days post-fertilization; FBS; fetal bovine serum; GSK3β; glycogen synthase kinase-3β; MAPKs; mitogen-activated protein k
The nonsteroidal antiinflammatory drug piroxicam reverses the onset of depressive-like behavior in 6-OHDA animal model of Parkinson's disease
Keywords: 5-HIAA; 5-hydroxyindoleacetic acid; 6-OHDA; 6-hydroxydopamine; ANOVA; analysis of variance; COX; cyclooxygenase; CSF; cerebrospinal fluid; EDTA; ethylenediaminetetraacetic acid; FST; forced swim test; HPLC; high-performance liquid chromatography; HVA; hom
Anti-apoptotic effect of modified Chunsimyeolda-tang, a traditional Korean herbal formula, on MPTP-induced neuronal cell death in a Parkinson's disease mouse model
Keywords: ABC; avidin-biotin peroxidase complex; DG; modified Chungsimyeolda-tang; FBS; fetal bovine serum; MYH; modified Youldahanso-tang; PD; Parkinson's disease; MEM; minimal essential medium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-
The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease
Keywords: 6-OHDA; 6-hydroxydopamine; ANOVA; analysis of variance; DOPAC; 3,4-dihydrophenylacetic acid; HPLC; high-performance liquid chromatography; IL; interleukin; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; MPP; 1-methyl-4-phenylpyridinium; M
Translational research for Parkinson׳s disease: The value of pre-clinical primate models
Keywords: PD; Parkinson׳s disease; SNpc; substantia nigra pars compacta; L-DOPA; Levodopa, 3,4-dihydroxyphenylalanine; 6OHDA; 6-hydroxydopamine; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; AADC; L-aromatic amino acid decarboxylase; TH; tyrosine hydroxylase
Effects of (-)-sesamin on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and dopaminergic neuronal cells of Parkinson's disease rat models
Keywords: (-)-Sesamin; 6-Hydroxydopamine-induced neurotoxicity; PC12 cells; 6-Hydroxydopamine-lesioned rat model of Parkinson's disease; Adjuvant therapeutics; DOPAC; 3,4-dihydroxyphenylacetic acid; ERK1/2; extracellular signal-regulated kinase; HVA; +acid; JNK1/2;
Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents l-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice
Keywords: 6-OHDA; 6-hydroxydopamine; AIM; abnormal involuntary movements; ANOVA; Analysis of variance; Gad; glutamic acid decarboxylase; l-DOPA; levodopa; LID; l-DOPA-induced dyskinesia; GABA; 6-hydroxydopamine; levodopa; dyskinesia; striatum; striatonigral;
Basic NeuroscienceX-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation
Keywords: Severe combined immunodeficiency rats; Xeno-transplantation; Parkinson's disease; Dopaminergic neurons; 6-Hydroxydopamine; Immune response;
Research reportAnxiolytic effects of prelimbic 5-HT1A receptor activation in the hemiparkinsonian rat
Keywords: Prelimbic medial prefrontal cortex; Anxiety; 5-HT1A receptor; 6-Hydroxydopamine; Parkinson's disease; Rat;
Basic neuroscienceMethodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease
Keywords: 6-Hydroxydopamine; Nigrostriatal pathway; Neurochemistry; Neuroprotection; Peptide; Intranasal administration; THpositive (+) neurons; tyrosine hydroxylase positive neurons; STS; staurosporine; 6-OHDA; 6-hydroxydopamine; DOPAC; 3,4-dihydroxyphenylacetic a
Respiratory deficits in a rat model of Parkinson's disease
Keywords: 6-OHDA; 6-hydroxydopamine; cVRG; caudal ventral respiratory group; fR; respiratory frequency; LC; locus coeruleus; MV; minute ventilation; PD; Parkinson's disease; phox2b-ir; phox2b immunoreactivity; preBötC; pre-Bötzinger complex; RTN; retrotrapezoid
Evidence for a role for α6â nAChRs in l-dopa-induced dyskinesias using parkinsonian α6â nAChR gain-of-function mice
Keywords: α-CtxMII; α-conotoxinMII; â; denotes the possible presence of other subunits in the receptor complex; 125I-RTI-121; 125I-3β-(4-iodophenyl)tropane-2β-carboxylic acid isopropyl ester; 6-OHDA; 6-hydroxydopamine; AIMs; abnormal involuntary movements; BS
Research reportA partial lesion model of Parkinson's disease in mice - Characterization of a 6-OHDA-induced medial forebrain bundle lesion
Keywords: Parkinson's disease; Mouse model; Medial forebrain bundle; 6-Hydroxydopamine; Behavioral test; Prediction model;
Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway
Keywords: 6-OHDA; 6-hydroxydopamine; DPI; diphenyleneiodonium; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence-activated cell sorting; FITC; fluorescein isothiocyanate; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSH; glutathione; LDH; lactate deh
Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents
Keywords: Parkinson's disease; Deoxygedunin; Neuroprotection; Brain derived neurotrophic factor; 6-Hydroxydopamine; MPTP;
Dorsomedial hindbrain catecholamine regulation of hypothalamic astrocyte glycogen metabolic enzyme protein expression: Impact of estradiol
Keywords: 6-OHDA; 6-hydroxydopamine; ARH; arcuate hypothalamic nucleus; CA; catecholamine; CV4; caudal fourth ventricle; GP; glycogen phosphorylase; GS; glycogen synthase; GSK3β1; glycogen synthase kinase-3-β; IIH; insulin-induced hypoglycemia; LHA; lateral hypot
Age and lesion-induced increases of GDNF transgene expression in brain following intracerebral injections of DNA nanoparticles
Keywords: 6-OHDA; 6-hydroxydopamine; AAV; adeno-associated virus; ANOVA; analysis of variance; BSA; bovine serum albumin; DA; dopamine; DNP; DNA nanoparticles; EDTA; ethylenediaminetetraacetic acid; eGFP; enhanced green fluorescent protein; ELISA; enzyme-linked imm
AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo
Keywords: 6-OHDA; 6-hydroxydopamine; AAV; adeno-associated viral vector; Bcl-2; B-cell lymphoma 2; CNS; central nervous system; ctl; contralateral; DAPI; 4â²,6-diamidino-2-phenylindole; DIV; day in vitro; DOPAC; 3,4-dihydroxyphenylacetic acid; EGFP; enhanced green
Basic NeuroscienceReviewα-Synuclein and nonhuman primate models of Parkinson's disease
Keywords: α-syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; AAV2; adeno-associated viral vector serotype 2/2; ALP; autophagy-lysosomal pathway; BBB; blood-brain-barrier; c-hGH; cadaver-derived human growth hormone; CK; casein kinases; DA; dopamine; DAT; dopamine
Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway
Keywords: 6-OHDA; 6-hydroxydopamine; ARE; antioxidant response element; BSA; bovine serum albumin; Cyt C; cytochrome c; DA; dopamine; DAPI; 4â²,6-diamidino-2-phenylindole; DCFH-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DMSO; dimethylsulfoxide; DOPAC; dih
Involvement of the Nrf2/HO-1 signaling pathway in sulfuretin-induced protection against amyloid beta25-35 neurotoxicity
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; amyloid beta; AD; Alzheimer's disease; AREs; anti-oxidant response elements; DCFH-DA; 2,7â²-dichlorofluorescin diacetate; DMSO; dimethyl sulfoxide; DMEM; Dulbecco's modified Eagle's medium; EMSA; electrophoretic mobi
Striatal tyrosine hydroxylase-positive neurons are associated with l-DOPA-induced dyskinesia in hemiparkinsonian mice
Keywords: 6-OHDA; 6-hydroxydopamine; AADC; aromatic acid decarboxylase; AIMs; abnormal involuntary movements; DA; dopamine; L-DOPA; L-3,4-dihydroxyphenylalanine; LID; L-DOPA-induced dyskinesia; MFB; medial forebrain bundle; NHS; normal horse serum; OD; optical dens
Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity
Keywords: 6-OHDA; 6-hydroxydopamine; AD; Alzheimer's disease; ARE; antioxidant response elements; DA; dopamine; DMF; dimethyl fumarate; DOPAC; dihydroxyphenylacetic acid; GCLC; glutathione cysteine ligase regulatory subunit; GCLM; glutathione cysteine ligase modu
Medicinal uses, phytochemistry and pharmacology of the genus Uncaria
Keywords: U1; Uncaria acida (Hunter) Roxb; U2; Uncaria africana G. Don; U3; Uncaria attenuate Korth; U4; Uncaria barbata Merr; U5; Uncaria bernaysii F. Muell; U6; Uncaria borneensis Havil; U7; Uncaria callophylla Blume ex Korth; U8; Uncaria canescens Korth; U9; Unc
Current knowledge and pharmacological profile of berberine: An update
Keywords: 5-HT; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BBB; blood brain barrier; BChE; butyrylcholinestesrase; CD; cluster of differentiation; Cdk; cyclin-dependent ki
MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model
Keywords: 6-OHDA; 6-hydroxydopamine; ADAM17; ADAM metallopeptidase domain 17; AMS; 4-acetamido-4â²-maleimidylstilbene-2, 2â²-disulfonic acid, disodium salt; ASK1; Apoptosis signal-regulating kinase 1; CIB1; Calcium and integrin-binding protein 1; C (in figure); V
The protein l-isoaspartyl (d-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells
Keywords: 6-OHDA; 6-hydroxydopamine; AdoMet; S-adenosyl-l-methionine; CaPIMT1; chick pea PIMT; DA; dopamine; DMSO; dimethyl sulfoxide; gly-LDL; glycated Low-Density Lipoprotein; H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; MAO; monoamine oxidase; MPTP;
Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
Keywords: AAD; active adenylation domain; 4-PBA; 4-phenylbutyric acid; 6-OHDA; 6-hydroxydopamine; ABCG5/8; ATP-binding cassette sub-family G member 5/8; AD; Alzheimer's disease; AIB1; amplified in breast cancer 1; AIP4; atrophin-1 interacting protein 4; AMPA; α-
Botulinum neurotoxin A subtype 2 reduces pathological behaviors more effectively than subtype 1 in a rat Parkinson's disease model
Keywords: 6-OHDA; 6-hydroxydopamine; ACh; acetylcholine; BoNT/A; botulinum neurotoxin subtype A; CNS; central nervous system; ChAT; choline acetyltransferase; PD; Parkinson's disease; PBS; phosphate-buffered saline; Acetylcholine; Botulinum neurotoxin; Parkinsonâ
Adipose stem cells-conditioned medium blocks 6-hydroxydopamine-induced neurotoxicity via the IGF-1/PI3K/AKT pathway
Keywords: Neuronal cell death; ASC-CM; 6-hydroxydopamine; IGF-1; AKT;
Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[18F]Mefway
Keywords: 6-hydroxydopamine; Hemiparkinsonian model; trans-[18F]Mefway; 5-HT1A receptors; MicroPET;
Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity
Keywords: AD; Alzheimer's disease; ANOVA; one-way analysis of variance; ATCC; American type culture collection; DA; dopamine; 7,8-DHF; 7,8-dihydroxyflavone; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescence; F
6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo
Keywords: GDF5; GDNF; 6-Hydroxydopamine; Dopaminergic; Parkinson's disease
Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease
Keywords: 6-OHDA; 6-hydroxydopamine; aCSF; artificial cerebrospinal fluid; MSN; medium spiny neuron; NMDAR; N-methyl-d-aspartate receptor; s/m EPSC; spontaneous/miniature excitatory postsynaptic current; sIPSC; spontaneous inhibitory postsynaptic current; TH; tyros
Radiological analysis of gastrointestinal dysmotility in a model of central nervous dopaminergic degeneration: Comparative study with conventional in vivo techniques in the rat
Keywords: (GI); gastrointestinal; (PD); Parkinson's disease; (SNpc); substantia nigra pars compact; (SO); sham-operated rats; (6-OHDA); 6-hydroxydopamine; (GC); geometric centre; (TH); tyrosine hydroxylase; (TBS); tris-buffered saline; (CBE); colonic expulsion of a
Activation of spinal α2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow
Keywords: I.t.; Intrathecal; I.p.; Intraperitoneal; PTX; Pertussis toxin; 6-OHDA; 6-hydroxydopamine; ADX; Adrenalectomy; ICR; Imprinting control region; PEC; The polyethylene glycol 400; ethanol; sodium carboxymethyl cellulose mixture; Gi; inhibitory G protein; DSP
Altered expression of dopamine receptors in cholinergic motoneurons of the hypoglossal nucleus in a 6-OHDA-induced Parkinson's disease rat model
Keywords: PD; Parkinson's disease; SN; substantia nigra; D1; dopamine receptor 1; D2; dopamine receptor 2; HN; hypoglossal nucleus; DMV; dorsal motor nucleus of the vagus; SqRT-PCR; semi-quantitative reverse transcription and polymerase chain reaction; 6-OHDA;
Research reportNeuropeptide S counteracts 6-OHDA-induced motor deficits in mice
Keywords: 6-OHDA; 6-hydroxydopamine; icv; intracerebroventricular injection; NPS; neuropeptide S; SN; substantia nigra; TH; tyrosine hidroxylase; Dopamine; Parkinson disease; Mouse; Neuropeptide S; Motor activity; 6-OHDA;
NMDA receptor antagonism potentiates the l-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats
Keywords: 6-OHDA rat model; Subthalamic nucleus; l-DOPA; NMDA receptor antagonist; Dopamine; In vivo microdialysis; 6-OHDA; 6-hydroxydopamine; AADC; aromatic amino acid decarboxylase enzyme; ANOVA; analysis of variances; AUC; area under the curve; DA; dopamine; DO
Research ReportSquamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models
Keywords: PD; Parkinson's disease; PI3K; phosphoinositide-3-kinase; α-Syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; TH; tyrosine hydroxylase; Co-IP; Co-Immunoprecipitation; FLZ; Parkinson's disease; Akt; α-synuclein; Tyrosine hydroxylase;
Research reportThe effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats
Keywords: 6-Hydroxydopamine; Parkinson's disease; Medial forebrain bundle; Striatum; Substantia nigra; Interneuron;
G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease
Keywords: GPR6; cAMP; Dopamine; Parkinson's disease; Dyskinesia; 6-Hydroxydopamine; In vivo microdialysis; Apomorphine