دانلود مقالات ISI درباره پروتئین anchoring A-kinase + ترجمه فارسی

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Absence of synemin in mice causes structural and functional abnormalities in heart

Keywords: پروتئین anchoring A-kinase; Costameres; Intermediate filament; AKAPs; Hypertrophic and dilated cardiomyopathy; Muscular dystrophy;  + dP/dt; maximal rate of left ventricular pressure rise; -dP/dt; maximal rate of left ventricular pressure fall;  + dP/dt-EDP; end-diastolic pressu

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

خانواده پرویلپین پروتئین قطره چربی: گیرنده های لیپولیز داخل سلولی

The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis

Keywords: پروتئین anchoring A-kinase; ABHD5; alpha beta hydrolase domain protein 5; AKAP; A-kinase anchoring protein; ATGL; adipose triglyceride lipase; CMA; chaperone mediated autophagy; DAG; diacylglycerol; DGAT2; acyl-CoA:diacylglycerol acyltransferase 2; FA; fatty acid; hsc70; heat shock

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

پیشرفت های اخیر در استراتژی های درمانی که بر تنظیم بیان کانال یون تمرکز می کنند

Recent advances in therapeutic strategies that focus on the regulation of ion channel expression

Keywords: پروتئین anchoring A-kinase; Ca2+ channel; K+ channel; Ca2+-activated Cl− channel; Transcription; Pre-mRNA splicing; Protein degradation; AD; Alzheimer's disease; ADPR; ADP ribose; AITC; allyl isothiocyanate; AKAP; A-kinase anchoring protein; AMPK; 5′ AMP-activated protein kinase

دانلود رایگان متن کامل مقاله ISI 171 صفحه سال انتشار : 2016 سفارش ترجمه

یک مرور تاریخی از پروتئین کیناز و مهار کننده های مولکولی کوچک هدفمند

A historical overview of protein kinases and their targeted small molecule inhibitors

Keywords: پروتئین anchoring A-kinase; AKAP; A-Kinase Anchoring Protein; ALL; acute lymphoblastic leukemia; A.S.; activation segment; CDK; cyclin-dependent kinase; CML; chronic myelogenous leukemia; C-spine; catalytic spine; EGFR; epidermal growth factor receptor; FGFR; fibroblast growth facto

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2015 سفارش ترجمه

استراتژی تحویل فاکتورهای بیولوژیک از هیدروژل های پلیمری مهندسی برای درمان درمانی

Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine

Keywords: پروتئین anchoring A-kinase; GFs; growth factors; ALG; alginate; HA; hyaluronic acid; HEP; heparin; PEI; polyethyleneimine; PHEMA; poly(2-hydroxyethyl methacrylate); PEG; poly(ethylene glycol); PEO; poly(ethylene oxide); DEX; dextran; PPO; poly(propylene oxide); PPG; poly(propylene g

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2014 سفارش ترجمه

Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA

Keywords: پروتئین anchoring A-kinase; A-kinase anchoring protein (AKAP); Dopamine; Histone deacetylase (HDAC); Histone deacetylase inhibitor (HDAC inhibitor); Brain derived neurotrophic factor (BDNF); Ventral tegmental area (VTA); Early life stress; Maternal deprivation (MD); Epigenetics; His

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides

Keywords: پروتئین anchoring A-kinase; Trypanosoma equiperdum; Regulatory subunits of the cAMP-dependent protein kinase; Gene cloning; Protein expression in bacteria; Protein purification; Biochemical characterization; Dourine; Trypanosomatid parasites; PKA; cAMP-dependent protein kinase; R; P

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2018 سفارش ترجمه

Disrupting sensitization of TRPV4

Keywords: پروتئین anchoring A-kinase; AKAP; A-kinase anchoring protein; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; TAT; transactivator of transcription; TRP; transient receptor potential, with respective subtypes; AKAP; inflammation; protein-protein interaction; TRP channel;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Targeting kinase signaling pathways with constrained peptide scaffolds

Keywords: پروتئین anchoring A-kinase; AKAP; A-kinase anchoring protein; Akt; protein kinase B; ALL; acute lymphoblastic leukemia; CBG; cyclin binding groove; CDK2; cyclin dependent kinase 2; CKII; casein kinase II; CKIIα; casein kinase II subunit alpha; CKIIβ; casein kinase II subunit beta;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells

Keywords: پروتئین anchoring A-kinase; GJ; Gap junction; Cx; Connexin; GJIC; GJ intercellular communication; PKA; cAMP-Dependent protein kinase; AKAP; A-kinase anchoring protein; AKB; A-kinase binding domain; ERM; Ezrin, radixin, moesin; hCG; Human chorion gonadotropin; ZO-1; Zonula occludens-

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology

Keywords: پروتئین anchoring A-kinase; PKA; cyclic-AMP dependent protein kinase/protein kinase A; cAMP; 3′,5′-cyclic adenosine monophosphate; ATP; adenosine 5-triphosphate; C subunits; catalytic subunits; R subunits; regulatory subunits; AKAP; A-kinase anchoring protein; AGC group of kinas

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Invited reviewMRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease

Keywords: پروتئین anchoring A-kinase; ABC; ATP-binding cassette; AC; adenylate cyclase; AKAP; A-kinase anchoring protein; AR; adenosine receptor; CABG; coronary artery bypass graft; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; COX; cyclooxygenase; δ-SPD; δ-sto

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Protein-protein interactions of PDE4 family members - Functions, interactions and therapeutic value

Keywords: پروتئین anchoring A-kinase; Phosphodiesterase; A-kinase anchoring protein; Drug targets; cAMP; Compartmentalisation; Protein kinase A; Protein-protein interaction;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Type II PKAs are anchored to mature insulin secretory granules in INS-1 β-cells and required for cAMP-dependent potentiation of exocytosis

Keywords: پروتئین anchoring A-kinase; Pancreatic; Endocrine; Insulin; Exocytosis; Potentiation; Protein kinase-A; cAMP; Compartmentalization; AKAP; A-Kinase anchoring protein; Epac; Exchange proteins directly activated by cAMP; GEF; Guanine nucleotide exchange factor; GLP-1; Glucagon-like pep

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

FRET biosensors reveal AKAP-mediated shaping of subcellular PKA activity and a novel mode of Ca2 +/PKA crosstalk

Keywords: پروتئین anchoring A-kinase; AKAP; A-Kinase Anchoring Protein; AKAR3; A-Kinase activity reporter 3; β2AR; β2-adrenergic receptor; [Ca2 +]i; intracellular calcium concentration; CaM; calcium-calmodulin; cAMP; cyclic adenosine monophosphate; CB4; calmodulin binding domain 4; CFP; cy

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2016 سفارش ترجمه

Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics

Keywords: پروتئین anchoring A-kinase; 3D lrECM; three-dimensional cultures of laminin-rich extracellular matrix; ACs; adenylyl cyclases; AKAP; A-kinase anchoring protein; ATP; adenosine triphosphate; β-AR; β adrenergic receptor; β-arr2; β-arrestin 2; BnT; benzylthio group; cAB; cAMP-bindi

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling

Keywords: پروتئین anchoring A-kinase; A-kinase anchoring protein; Protein kinase A; Protein-protein interaction; Cardiovascular; Cancer;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy

Keywords: پروتئین anchoring A-kinase; PDEs; phosphodiesterases; AKAP; A-kinase anchoring protein; cAMP; 3′,5′-cyclic monophosphate; Epac; exchange protein directly activated by cAMP; PKA; protein kinase A; PKC; protein kinase C; PKD; protein kinase D; UCR; upstream conserved region; β-AR

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Associate Editor: P. HolzerHow anchoring proteins shape pain

Keywords: پروتئین anchoring A-kinase; Accessory protein; AKAP; Pain; Scaffolding protein; Sensitisation; AKAP; A-kinase anchoring protein; AMPA; 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid; ASIC; Acid-sensing ion channel; cAMP; Cyclic adenosine monophosphate; CaV1.2; L-type vol

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling

Keywords: پروتئین anchoring A-kinase; 5-HT; 5-hydroxytryptamine; AKAP; A-kinase anchoring protein; DMSO; dimethyl sulfoxide; GRK; G protein-coupled receptor kinase; HEK293; human embryonic kidney cell line; IBMX; isobutylmethylxanthine; IP; immunoprecipitation; PDE; phosphodiesterase; PKA; pr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in can

Keywords: پروتئین anchoring A-kinase; luteolin; 3′,4′,5,7-tetrahydroxyflavone; IFN; interferon; JAK; Janus kinase; STAT; signal transducer and activator of transcription; ISRE; interferon α-stimulated response element; PDE; phosphodiesterase; cAMP; cyclic adenosine 3′,5′-monophosphat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in cardiac fibroblasts

Keywords: پروتئین anchoring A-kinase; GTP; guanosine triphosphate; AKAP; A-kinase anchoring protein; GEF; guanine nucleotide exchange factor; AT1Rs; type I angiotensin II receptors; sh; short hairpin; ECM; extracellular matrix; α-SMA; α-smooth muscle actin; TGF-β; transforming growth facto

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Systems biology of synaptic plasticity: A review on N-methyl-d-aspartate receptor mediated biochemical pathways and related mathematical models

Keywords: پروتئین anchoring A-kinase; AC; adenylyl cyclase; AKAP; A-kinase anchoring protein; AMPAR; A-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; CaM; calmodulin; CaMKII; Ca2+/CaM-dependent protein kinase II; cAMP; cyclic adenosine monophosphate; HFS; high frequency stimula

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease

Keywords: پروتئین anchoring A-kinase; LRRK2; Parkinson's disease; Kinase; GTPase; Inhibitor; Endocytosis; Autophagy; Vesicle trafficking; Neuronal dysfunction; Rab protein; AKAP; A-kinase anchoring protein; ANK; ankyrin repeat; AP; adaptor protein; ARM; armadillo repeat; CHIP; carboxyl termin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Post-translational modification of mitochondria as a novel mode of regulation

Keywords: پروتئین anchoring A-kinase; Abl; Abelson murine leukemia viral oncogene homolog 1; AKAP; A-kinase anchoring protein; DUB; deubiquitinating enzymes; FAO; fatty acid oxidation; GCN5L1; GCN5-like 1; IMM; inner mitochondrial membrane; IMS; intermembrane space; MEFs; mouse embryonic fibr

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Src kinases are important regulators of mitochondrial functions

Keywords: پروتئین anchoring A-kinase; OXPHOS; oxidative phosphorylation; ETS; electron transport system; PKA; cAMP-dependent protein kinase; ROS; reactive oxygen species; Y; tyrosine; MEF; mouse embryonic fibroblasts; ER; endoplasmic reticulum; PKCδ; protein kinase C δ; RBM; rat brain mitoc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA

Keywords: پروتئین anchoring A-kinase; 7-TM; seven transmembrane domain; AC; adenylate cyclase; AKAP; A-kinase anchoring protein; Bnz-cAMP; N6-benzoyl-cAMP; 8-CPT; 8-CPT-2-Me-cAMPS; cGCPs; cerebellar granule cell progenitors; IBMX; isobutylmethylxanthine; FSK; forskolin; GliA; Gli activator; G

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Extramitochondrial OPA1 and adrenocortical function

Keywords: پروتئین anchoring A-kinase; [Ca2+]m; mitochondrial Ca2+ concentration; AKAP; A-kinase anchoring protein; CaMKII; Ca2+/calmodulin-dependent kinase II; COX IV; cytochrome c oxidase IV; db-cAMP; dibutiryl-cAMP; emOPA1; extramitochondrial OPA1; HSL; hormone-sensitive lipase; IMM; inner

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Receptor-mediated Ca2 + and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin

Keywords: پروتئین anchoring A-kinase; AKAP; A-Kinase Anchoring Protein; ATP; adenosine triphosphate; β2AR; β2-adrenergic receptor; BAPTA-AM; 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester); BIM; bisindolylmaleimide; [Ca2 +]i; intracellular calcium

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes

Keywords: پروتئین anchoring A-kinase; LTCC; L-type Ca2+ channel; EC; excitation-contraction; ICa,L; L-type Ca2+ current; SR; sarcoplasmic reticulum; T-tubules; transverse tubules; CICR; Ca2+-induced Ca2+ release; [Ca2+]i; free intracellular Ca2+ concentration; PKA; protein kinase A; Cav; ca

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Cyclic AMP-mediated immune regulation - Overview of mechanisms of action in T cells

Keywords: پروتئین anchoring A-kinase; AC; Adenylyl cyclase; AKAP; A-kinase anchoring protein; AKAP-KL; AKAP-kidney lung; AKB; A-kinase binding domain; AP-1; Activator protein 1; ATF; Activation transcription factor; C; Catalytic (subunit of PKA); CBP; CREB-binding protein; CNG; Cyclic nucleot

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Stimulation of β2-adrenergic receptors inhibits calcineurin activity in CD4+ T cells via PKA–AKAP interaction

Keywords: پروتئین anchoring A-kinase; Adrenergic receptor; Sympathetic nervous system; Noradrenaline; T cells; Calcineurin; Protein phosphatase 2B; Protein kinase A; A-kinase anchoring protein

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of PKA anchoring to A-kinase anchoring proteins impairs consolidation and facilitates extinction of contextual fear memories

Keywords: پروتئین anchoring A-kinase; A-kinase anchoring protein; Ht31; Learning; Memory; Fear conditioning; Mouse; Hippocampus; Extinction; SuperAKAP-IS

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation

Keywords: پروتئین anchoring A-kinase; A-kinase anchoring protein; Cyclic adenosine monophosphate; Protein kinase B/Akt; cAMP-dependent protein kinase; Exchange proteins directly activated by cAMP; Neuron; AKAP150; HT-4

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Both exposure to a novel context and associative learning induce an upregulation of AKAP150 protein in mouse hippocampus

Keywords: پروتئین anchoring A-kinase; A-kinase anchoring protein; Contextual fear conditioning; Memory

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels

Keywords: پروتئین anchoring A-kinase; Excitable membrane; Synaptic transmission; KCNQ/M K+ channels; A-kinase anchoring protein; Protein kinase C; Muscarinic acetylcholine receptor; Postsynaptic modulation;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2005 سفارش ترجمه

A novel isoform of Cbl-associated protein that binds protein kinase A

Keywords: پروتئین anchoring A-kinase; A-kinase anchoring protein; Protein kinase A; Cbl-associated protein; Heart; SORBS1;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Synaptic and subcellular localization of A-kinase anchoring protein 150 in rat hippocampal CA1 pyramidal cells: Co-localization with excitatory synaptic markers

Keywords: پروتئین anchoring A-kinase; protein kinase A; calcineurin; post-synaptic density; GABAA receptors; receptor phosphorylation; receptor targeting; AKAP; A-kinase anchoring protein; AKAP150-IR; A-kinase anchoring protein 150 immunoreactivity; EM; electron microscopic; GABAA; GABA recep

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Kinase signaling cascades in the mitochondrion: a matter of life or death

Keywords: پروتئین anchoring A-kinase; AKAP; A-kinase anchoring protein; Akt/PKB; protein kinase B; DAG; diacylglycerol; ERK; extracellular signal-regulated protein kinase; GSK3β; glycogen synthase kinase 3β; IP3; inositol triphosphate; JNK/SAPK; c-Jun N terminal kinase/stress-activated prot

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Tyrosine phosphorylation in mitochondria: A new frontier in mitochondrial signaling

Keywords: پروتئین anchoring A-kinase; AKAP; A-kinase anchoring protein; CcO; cytochrome c oxidase; DSP; dual-specificity phosphatase; EGFR; epidermal growth factor receptor; ETC; electron transport chain; Hsp; heat shock protein; MKP-1; MAPK phosphatase 1; PH; Pleckstrin homology; PHGPx; phos

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Nesprin-1α contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope

Keywords: پروتئین anchoring A-kinase; cAMP; adenosine 3′:5′-cyclic monophosphate; AKAP; A-kinase anchoring protein; GFP; green fluorescent protein; GST; glutathione-S-transferase; PDE4D3; type 4D3 phosphodiesterase; RyR; ryanodine receptor; mAKAP; Nesprin-1; Nuclear envelope; Spectrin rep

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Macromolecular complexes of cystic fibrosis transmembrane conductance regulator and its interacting partners

Keywords: پروتئین anchoring A-kinase; Cystic fibrosis transmembrane conductance regulator; Macromolecular complex; PDZ protein; Interacting partner; ABC; ATP-binding cassette; AFM; atomic force microscopy; AKAP; A-kinase anchoring protein; AMPK; AMP-activated kinase; AP-2; adaptor protein com

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه

Peptide inhibitors of protein kinases-discovery, characterisation and use

Keywords: پروتئین anchoring A-kinase; AKAP; A-Kinase Anchoring Protein; EGF-R; Epidermal Growth Factor-Receptor; GSK; Glycogen Synthase Kinase; IC50; concentration of compound to achieve 50% inhibition; JIP; JNK Interacting Protein; JNK; c-Jun N-terminal Kinase; Ki; inhibition constant; MLCK;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2005 سفارش ترجمه