دانلود مقالات ISI درباره AD، بیماری آلزایمر + ترجمه فارسی

DnaJA1 Antagonizes Constitutive Hsp70-Mediated Stabilization of Tau

Keywords: AD، بیماری آلزایمر; CMA, chaperone-mediated autophagy; AD, Alzheimer's disease; IP, immunoprecipitationtau; chaperones; DnaJA1; Hsp70; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Intranasal administration of nerve growth factor ameliorate β-amyloid deposition after traumatic brain injury in rats

Keywords: AD، بیماری آلزایمر; Aβ, amyloid-β; AD, Alzheimer's disease; APP, amyloid protein precursor; CNS, central nervous system; ELISA, enzyme-linked immunosorbent assay; IN, intranasal; INA, intranasal application; MWM, Morris water maze; NGF, nerve growth factor; p75NTR, p75 neuro

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Brain Derived Neurotrophic Factor: A novel neurotrophin involved in psychiatric and neurological disorders

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's Disease; BDNF, Brain Derived Neurotrophic Factor; BDNFMet, Valine to Methionine substitution at position 66 in the pro-domain of BDNF gene; CSF, Cerebrospinal fluid; DT, Delirium Tremens; HD, Huntington's Disease; mBDNF, Proteolytically pr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

MicroRNAs in neurodegenerative diseases and their therapeutic potential

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; AGO, Argonaute; ALS, Amyotrophic lateral sclerosis; APP, amyloid precursor protein; BACE-1, β-amyloid precursor protein; BSE, bovine spongiform encephalopathy; CJD, Creutzfeldt–Jakob disease; DGCR8, DiGeorge syndrome critical regi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Calmodulin antagonizes amyloid-β peptides-mediated inhibition of brain plasma membrane Ca2+-ATPase

Keywords: AD، بیماری آلزایمر; Aβ, amyloid-β peptide; AD, Alzheimer's disease; PBS, Phosphate buffered saline; PC, Phosphatidylcholine; PMCA, Plasma membrane Ca2+-ATPase; TBS, Tris buffered salineAmyloid β-peptide; PMCA; Calmodulin; Chymotrypsin; Calpain

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model

Keywords: AD، بیماری آلزایمر; OA, okadaic acid; GSK3, glycogen synthase kinase 3; NFTs, neurofibrillary tangles; PTEN, phosphatase and tensin homologue deleted on chromosome 10; AD, Alzheimer's disease; PI3K, phosphoinositide 3-kinasePTEN; Akt/PKB; Glycogen synthase kinase 3; Alzheime

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, amyloid-beta; CAT, catalase; SOD, superoxide dismutase; Nrf2, nuclear factor erythroid 2-related factor 2; ERK1/2, extracellular signal-regulated kinases 1 and 2; HBSS, Hank's blanced salt solution; ELISA, enzyme-linked immuno

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats

Keywords: AD، بیماری آلزایمر; Aβ, β-amyloid peptide; AD, Alzheimer's disease; CAD, caspase-activated DNase; ELISA, enzyme-linked immunosorbent assay; IL-1β, interleukin 1β; POCD, post-operative cognitive dysfunction; SpO2, pulse oximeter oxygen saturation; TNF-α, tumor necrosis factor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats

Keywords: AD، بیماری آلزایمر; Aβ, amyloid beta; AD, Alzheimer's disease; ANOVA, Analysis of Variance; APP, amyloid precursor protein; ARE, antioxidant response element; CREB, Ca+/cAMP-response element binding protein; ECL, electrochemiluminescence; ERK, extracellular signal-regulated

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, β-amyloid peptide; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; ThT, thioflavin T; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; TEM, transmission electron microscope; APP, β-amyloi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models

Keywords: AD، بیماری آلزایمر; PD, Parkinson's disease; PP2A, phosphatase 2A; p-Ser 129, α-Synuclein phosphorylated at serine 129; Lv-, lentiviral; AD, Alzheimer's disease; FTDP-17, Frontotemporal dementia with Parkinsonism linked to chromosome 17; CBD, corticobasal degeneration; PSP,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Amyloid precursor protein (APP) regulates synaptic structure and function

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; APP, amyloid precursor protein; eGFP, enhanced green fluorescent protein; LTP, long-term potentiation; PPF, paired-pulse facilitation; CM, conditioned medium; PBS, phosphate-buffered saline; fEPSP, excitatory postsynaptic potentia

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: Possible implication for neurodegenerative diseases

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Asp, Airflow Spirogram; AT8 +, AT8 positively stained; CSp, Chest Spirogram; KF, Kolliker–Fuse; nA, Nucleus Ambiguus; NRA, Nucleus Retroambiguus; PAG, Periaqueductal Gray; Rf, Respiratory frequency; WT, WildtypeTauopathy; Anesthes

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The renaissance of Ca2+-binding proteins in the nervous system: secretagogin takes center stage

Keywords: AD، بیماری آلزایمر; AA, amino acid; AD, Alzheimer's disease; ARFGAP2/3, ADP-ribosylation factor GTPase-activating protein 2/3; bp, base pair; CA, cornu ammonis subfields of the hippocampus; [Ca2+]i, intracellular Ca2+ concentration; CB, calbindin D28k; CBP, Ca2+-binding prot

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer's disease brain

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, beta amyloid; apoE4, apolipoprotein 4; APP, amyloid precursor protein; nApoE4CF, Amino-terminal apoE4 carboxyl-terminal fragment; MMP, matrix metalloproteinase; NFTs, neurofibrillary tangles; PHF, paired helical filamentsApoli

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Dementia: Alzheimer pathology and vascular factors: From mutually exclusive to interaction

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's Disease; APP, Amyloid precursor protein; ApoE, Apolipoprtein E; CSF, Cerebrospinal fluid; DSM-IV, Diagnostic and statistical manual of mental disorders, 4th edition; DTI, Diffusion tensor imaging; MTA, Medial temporal lobe atrophy; PET, Po

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; APP, amyloid precursor protein; APLP2, amyloid precursor-like protein 2; UTR, untranslated region; miRNAs, microRNAs; Aβ, beta-amyloid peptide; CNS, central nervous system; PD, Parkinson's disease; SNCA, alpha-synuclein; Bcl-2, B-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Memory defect induced by beta-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms

Keywords: AD، بیماری آلزایمر; AChEIs, cholinesterase inhibitors; Aβ, beta-amyloid; AD, Alzheimer's disease; ChAT, choline acetyltransferase; M receptor, muscarinic cholinergic receptor; AChE, cholinesterase; BDNF, brain derived neurotrophic factor; LTP, long term potentiation; LTD, lo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Chemical profiling and biological screening of Thymus lotocephalus extracts obtained by supercritical fluid extraction and hydrodistillation

Keywords: AD، بیماری آلزایمر; AAPH, 2,2′-azobis(2-amidinopropane) dihydrochloride; ACh, acetylcholine; AChE, acetylcholinesterase; AD, Alzheimer's disease; ATCI, acetylthiocholine iodide; BChE, butyrylcholinesterase; BTCI, butyrylthiocholine chloride; ChE, cholinesterase; CO2, carbon

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Modulation of beta-amyloid aggregation by engineering the sequence connecting beta-strand forming domains

Keywords: AD، بیماری آلزایمر; Aβ, beta-amyloid; AD, Alzheimer's disease; HCD, Aβ hydrophobic central domain; HPLC, high performance liquid chromatography; MALDI-TOF, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; 5-FAM, 5-carboxyfluorescein; PBSA, phosph

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Protein biomarkers for in vitro testing of toxicology

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; ANXA3, Annexin A3; API, atmospheric pressure ionization; CE, capillary electrophoresis; Da, Dalton; DNMT, DNA methyltransferases; ESI, electro spray ionization; EST, embryonic stem cell test; ELISA, enzyme-linked immunosorbent ass

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Cholesterol Promotes the Interaction of Alzheimer β-Amyloid Monomer with Lipid Bilayer

Keywords: AD، بیماری آلزایمر; Aβ, amyloid-β; AD, Alzheimer's disease; APP, amyloid precursor protein; MD, molecular dynamics; SDC, self-diffusion coefficient; SASA, solvent-accessible surface area; PDB, Protein Data Bank; VDW, van der Waals; POPC, 1-palmitoyl-2-oleoylphosphatidylcholi

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

NMDA receptors and metaplasticity: Mechanisms and possible roles in neuropsychiatric disorders

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; 5AR, 5-alpha reductase; AMPARs, AMPA class of glutamate receptors; Aβ, beta-amyloid; BDNF, brain-derived neurotrophic factor; JNK, c-Jun-N-terminal kinase; CREB, cyclic AMP response element binding protein; LTP-D, depotentiation;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

Keywords: AD، بیماری آلزایمر; DG, DNA glycosylase; AP, abasic; APE1, AP endonuclease 1; PNKP, polynucleotide 5′ kinase/3′ phosphatase; ROS, reactive oxygen species; AD, Alzheimer's disease; PD, Parkinson's disease; Pol, DNA polymerase; Lig, DNA ligase; FEN-1, flap endonuclease 1; BER,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein

Keywords: AD، بیماری آلزایمر; Aβ, Amyloid β peptide; AD, Alzheimer's disease; CD, circular dichroism; CP, cross polarization; DIPSHIFT, dipolar coupling and chemical shift correlation; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; DMPS, 1,2-dimyristoyl-sn-glycero-3-phosphoserine;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease

Keywords: AD، بیماری آلزایمر; ADEPT, Alzheimer's Disease Exercise Program Trial; CDR, Clinical Dementia Rating; MCI, mild cognitive impairment; AD, Alzheimer's disease; the Y, YMCA of Greater Kansas City; THR, target heart rate; KU ADC, University of Kansas Alzheimer's Disease Center;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, amyloid-β peptide; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; APP, amyloid-β precursor protein; ANOVA, analysis of variance; BDNF, brain derived neurotrophic factor; Ct, cycle threshold; DGS, donor goat serum

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; Aβ, β-amyloid; APP, amyloid precursor protein; CNS, central nervous system; hAPP, human APP; CSF, cerebrospinal fluid; PDB, Protein Data Bank; CDR, complementarity-determining region; PBS, phosphate-buffered saline; BSA, bovine se

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease

Keywords: AD، بیماری آلزایمر; Aβ, amyloid-beta; AD, Alzheimer's disease; BACE-1, beta-site APP-cleaving enzyme 1; miRNAs, microRNAs; miR-124, microRNA-124miR-124; BACE1/β-secretase; Aβ-induced neurotoxicity; Cell death; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Insulin in the brain: There and back again

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APP, Amyloid precursor protein; BBB, Blood–brain barrier; BEC, Brain endothelial cell; CNS, Central nervous system; CSF, Cerebrospinal fluid; DM1, Diabetes mellitus type

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells

Keywords: AD، بیماری آلزایمر; AA, arachidonic acid; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; asa, aspirin; cel, celecoxib; CNS, central nervous system; COX-1, cyclooxygenase-1; COX-2, cyclooxygenase-2; eto, etoricoxib; HWBA, human whole blood assay; IκBα, inhibitor

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; PD, Parkinson's disease; CR, Congo red; ThT, thioflavin T; EM, electron microscopy; FCS, fluorescence correlation spectroscopy; ANS, 1-anilino-8-naphthalene sulfonate; MD, molecular dynamics; ROS, reactive oxygen species; MTT, 3-(

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; ADAD, autosomal dominant Alzheimer's disease; ApoE4, apolipoprotein allele ɛ4; APP, amyloid precursor protein; BACE, β-secretase; CERAD, Consortium to Establish a Registry of Alzheimer's Disease; CSF, cerebrospinal fluid; EOAD, ea

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

Keywords: AD، بیماری آلزایمر; Aβ, amyloid-β-peptide; AD, Alzheimer's disease; CD, circular dichroism; NMDAR, N-methyl-d-aspartate receptors; PD, Parkinson's disease; PrP, prion protein; αSyn, α-synuclein; ThT, thioflavin T; TSEs, transmissible spongiform encephalopathies; TEM, transmi

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells

Keywords: AD، بیماری آلزایمر; Aβ, amyloid β peptide; AD, Alzheimer's disease; APPSwe, amyloid precursor protein Swedish mutant; CPA, cyclopiazonic acid; ER, endoplasmic reticulum; FCCP, carbonyl cyanide p-(trifluoromethoxy) phenyl hydrazone; G-418, geneticin; PS1, presenilin 1; SERCA,

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Central angiotensin converting enzyme facilitates memory impairment in intracerebroventricular streptozotocin treated rats

Keywords: AD، بیماری آلزایمر; ACE, angiotensin converting enzyme; AChE, acetylcholinesterase; aCSF, artificial cerebrospinal fluid; AD, Alzheimer's disease; Aβ, amyloid beta; BSA, bovine serum albumin; DCF-DA, 2′,7′-dichlorofluorescein-diacetate; DTNB, 5,5′-dithiobis (2-nitrobenzoic a

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

Keywords: AD، بیماری آلزایمر; Parkinson's disease; Neuroinflammation; Systemic inflammation; Microglia; Cytokines; Immunomodulatory therapies1-MPP+, 1-methyl-4-phenylpyridinium; 3′-UTR, three prime untranslated region; 6-OHDA, 6-hydroxydopamine; AD, Alzheimer's disease; ALS, amyotroph

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Nanotechnological advances for the delivery of CNS therapeutics

Keywords: AD، بیماری آلزایمر; ABC transporter, ATP-binding cassette membrane transporter; AD, Alzheimer's disease; ApoE, apolipoprotein E; BBB, blood–brain barrier; BCNU, 1,3-bis(2-chloroethyl)-1-nitrosourea; BCSFB, blood–cerebro spinal fluid barrier; BCRP, Breast Cancer Resistance Pr

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Molecular Interactions of Alzheimer's Aβ Protofilaments with Lipid Membranes

Keywords: AD، بیماری آلزایمر; Aβ, amyloid β; AD, Alzheimer's disease; MD, molecular dynamics; POPE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine; COM, center(s) of massAlzheimer's amyloid β peptide fibrils; amyloid protofilament structure; molecular dynamics simulations; amyl

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

The effect of Alzheimer's disease and Parkinson's disease on olfaction: A meta-analysis

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; PD, Parkinson's disease; UPSIT, University of Pennsylvania smell identification testAlzheimer's disease; Meta-analysis; Olfaction; Parkinson's disease

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Tau as a therapeutic target in neurodegenerative disease

Keywords: AD، بیماری آلزایمر; MAP, microtubule associated protein; NFT, neurofibrillary tangle; AD, Alzheimer's disease; MTBR, microtubule binding repeat; Aβ, amyloid beta; PiD, Pick's disease; CBD, corticobasal degeneration; PSP, progressive supranuclear palsy; FTDP-17, frontotempora

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

Keywords: AD، بیماری آلزایمر; AChEIs, acetylcholinesterase inhibitors; Aβ, amyloid-β; APP, amyloid precursor protein; AD, Alzheimer's disease; ApoE ε4, apolipoprotein E; BACE, β-site βAPP cleaving enzyme; IVIg, intravenous immunoglobulin; NFTs, neurofibrillary tangles; NMDA, N-methyl-

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

Do tocotrienols have potential as neuroprotective dietary factors?

Keywords: AD، بیماری آلزایمر; 12-HPETE, 12-hydroperoxy-eicosatetraenoic acid; α-TTP, α-tocopherol transfer protein; Aβ, amyloid-β; AD, Alzheimer's disease; AHA, American Heart Association; APP, amyloid precursor protein; DMBA, 7,12-dimethylbenz[α]anthracene; ERK, extracellular signal-

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

Metal ions as modulators of protein conformation and misfolding in neurodegeneration

Keywords: AD، بیماری آلزایمر; Aβ, amyloid-β peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; CJD, Creutzfeldt–Jakob disease; CNS, central nervous system; CSF, cerebrospinal fluid; HD, Huntington's disease; IDP, intrinsically disorde

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

Preclinical studies of potential amyloid binding PET/SPECT ligands in Alzheimer's disease

Keywords: AD، بیماری آلزایمر; Aβ, amyloid β; AD, Alzheimer's disease; APP, amyloid precursor protein; BBB, blood-brain barrier; BTA, benzothiazole; CSF, cerebrospinal fluid; CT, computed tomography; MOM, methoxymethyl; MRI, magnetic resonance imaging; NSAID, nonsteroidal anti-inflamma

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

Therapeutic approaches to preventing cell death in Huntington disease

Keywords: AD، بیماری آلزایمر; HD, Huntington disease; AD, Alzheimer's disease; PD, Parkinson's disease; MS, multiple sclerosis; ALS, amyotrophic lateral sclerosis; FBDD, fragment-based drug discovery; HTT, huntingtin gene; Htt, huntingtin protein; CAG, cytosine-adenine-guanine; Q, glu

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Brain excitability and connectivity of neuronal assemblies in Alzheimer's disease: From animal models to human findings

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; MCI, Mild Cognitive Impairment; aMCI, amnestic Mild Cognitive Impairment; CSF, cerebrospinal fluid; MRI, Magnetic Resonance Imaging; Aβ, amyloid-β; APP, Amyloid Precursor Protein; NFTs, NeuroFibrillary Tangles; PS, presenilin; CFC

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Phytocannabinoids as novel therapeutic agents in CNS disorders

Keywords: AD، بیماری آلزایمر; AD, Alzheimer's disease; AED, anti-epileptic drugs; AEA, arachidonylethanolamide; 2-AG, 2-arachidonylglycerol; CBC, cannabichromene; CBD, cannabidiol; CBDV, cannabidivarin; CB, cannabinoid; CBG, cannabigerol; CBN, cannibinol; DAGLα, diacylglycerol lipase

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Structural features and cytotoxicity of amyloid oligomers: Implications in Alzheimer's disease and other diseases with amyloid deposits

Keywords: AD، بیماری آلزایمر; Aβ, amyloid beta; AD, Alzheimer's disease; FRET, fluorescence resonance energy transfer; CD, circular dichroism; DLS, dynamic light scattering; NMR, nuclear magnetic resonance; MALDI-TOF, matrix-assisted laser desorption/ionization-time-of flight; NUP, na

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2012 سفارش ترجمه

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

Keywords: AD، بیماری آلزایمر; Aβ, beta-amyloid; AD, Alzheimer's disease; AMPK, AMP activated protein kinase; Atg, autophagic related gene; CNS, central nervous system; Deptor, DEP-domain-containing mTOR-interacting protein; 4EBP1, eukaryotic initiation factor 4E-binding protein 1; eIF

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2012 سفارش ترجمه