Keywords: Costameres; Intermediate filament; AKAPs; Hypertrophic and dilated cardiomyopathy; Muscular dystrophy; Â +Â dP/dt; maximal rate of left ventricular pressure rise; -dP/dt; maximal rate of left ventricular pressure fall; Â +Â dP/dt-EDP; end-diastolic pressu
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Keywords: PKA; cAMP; AKAP; Metabolism; Cancer; Mitochondria;
Keywords: AC; adenylyl cyclase; AKAP; A kinase anchoring protein; BACE; β-secretase; C1; AC catalytic domain 1; C2; AC catalytic domain 2; CaM; calmodulin; GPCR; G protein-coupled receptor; PDE; phosphodiesterase; PKA; protein kinase A; PKC; protein kinase C; PP2A
Keywords: ABHD5; alpha beta hydrolase domain protein 5; AKAP; A-kinase anchoring protein; ATGL; adipose triglyceride lipase; CMA; chaperone mediated autophagy; DAG; diacylglycerol; DGAT2; acyl-CoA:diacylglycerol acyltransferase 2; FA; fatty acid; hsc70; heat shock
Keywords: Ach; acetylcholine (Ach); Ad; adrenaline; AKAP; A kinase anchoring protein; Ano1; anoctamin-1 Ca2 +-activated Clâ channel encoded by the ANO1 gene; α-SMA; α-smooth muscle actin; ASMCs; atypical smooth muscle cells; eYFP; enhanced-yellow fluorescent p
Keywords: cardiomyopathy; catecholamine; gene therapy; heart failure; AAV; adeno-associated virus; AC; adenylyl cyclase; AC6mut; AC6 mutant, contains an amino acid substitution that reduces its catalytic activity; Ad5; adenovirus-5; AKAP; A-kinase-anchoring protein
Keywords: Ca2+ channel; K+ channel; Ca2+-activated Clâ channel; Transcription; Pre-mRNA splicing; Protein degradation; AD; Alzheimer's disease; ADPR; ADP ribose; AITC; allyl isothiocyanate; AKAP; A-kinase anchoring protein; AMPK; 5â² AMP-activated protein kinase
Keywords: AKAP; A-Kinase Anchoring Protein; ALL; acute lymphoblastic leukemia; A.S.; activation segment; CDK; cyclin-dependent kinase; CML; chronic myelogenous leukemia; C-spine; catalytic spine; EGFR; epidermal growth factor receptor; FGFR; fibroblast growth facto
Keywords: GFs; growth factors; ALG; alginate; HA; hyaluronic acid; HEP; heparin; PEI; polyethyleneimine; PHEMA; poly(2-hydroxyethyl methacrylate); PEG; poly(ethylene glycol); PEO; poly(ethylene oxide); DEX; dextran; PPO; poly(propylene oxide); PPG; poly(propylene g
Keywords: AF; atrial fibrillation; AKAP; A-kinase-anchoring protein; AP; action potential; β-AR; β-adrenoceptor; CaMKII; Ca2 +/calmodulin-dependent protein kinase type-II; CKIP-1; casein kinase-2 interacting protein-1; cMyBP-C; cardiac myosin-binding protein-C;
Keywords: AKAP; A-kinase-Anchoring Proteins; ATP; Adenosine Triphosphate; ADP; Adenosine Diphosphate; Ca2+; calcium; CaM; Calmodun; CamKII; Calcium/calmodulin-dependent Protein Kinase II; CSQ; Calsequestrin; CVD; Cardiovascular Disease; CmC; 4-chloro- m-cresol (CmC
Keywords: AKAP; A-kinase anchor protein; Ang II; angiotensin II; AP; action potential; APD; action potential duration; BH4; tetrahydrobiopterin; cAMP; cyclic adenosine monophosphate; CaM; calmodulin; CaMKII; Ca/calmodulin-dependent protein kinase II; CaMKIIδC; cyt
Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2
Keywords: Constrained peptide; PKA; AKAP; Isoform specificity; AKAP inhibitor; Stapled peptide;
Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA
Keywords: A-kinase anchoring protein (AKAP); Dopamine; Histone deacetylase (HDAC); Histone deacetylase inhibitor (HDAC inhibitor); Brain derived neurotrophic factor (BDNF); Ventral tegmental area (VTA); Early life stress; Maternal deprivation (MD); Epigenetics; His
Mitochondrial cAMP-PKA signaling: What do we really know?
Keywords: Mitochondria; cAMP; PKA; AKAP; Phosphorylation;
A-Kinase-Anchoring Protein (AKAP150) is expressed in Astrocytes and Upregulated in Response to Ischemia
Keywords: AKAP; A-Kinase-Anchoring Protein; BBSS; bicarbonate-buffered balanced salt solution; tMCAO; transient middle cerebral artery occlusion; potassium uptake; membrane potential; middle cerebral artery occlusion; siRNA; cortical astrocytes;
The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides
Keywords: Trypanosoma equiperdum; Regulatory subunits of the cAMP-dependent protein kinase; Gene cloning; Protein expression in bacteria; Protein purification; Biochemical characterization; Dourine; Trypanosomatid parasites; PKA; cAMP-dependent protein kinase; R; P
Disrupting sensitization of TRPV4
Keywords: AKAP; A-kinase anchoring protein; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; TAT; transactivator of transcription; TRP; transient receptor potential, with respective subtypes; AKAP; inflammation; protein-protein interaction; TRP channel;
Targeting kinase signaling pathways with constrained peptide scaffolds
Keywords: AKAP; A-kinase anchoring protein; Akt; protein kinase B; ALL; acute lymphoblastic leukemia; CBG; cyclin binding groove; CDK2; cyclin dependent kinase 2; CKII; casein kinase II; CKIIα; casein kinase II subunit alpha; CKIIβ; casein kinase II subunit beta;
Modulation of the TRPV4 ion channel as a therapeutic target for disease
Keywords: 4αPDD; 4α-phorbol 12,13-didecanoate; AHR; airway hyperresponsiveness; AKAP; A-kinase anchor protein; ALI; acute lung injury; BKCa; large conductance calcium-activated potassium channel; CFTR; cystic fibrosis transmembrane conductance regulator; COPD; ch
Calcineurin signaling in the heart: The importance of time and place
Keywords: AID; autoinhibitory domain of calcineurin; AKAP; A kinase anchor protein; AngII; angiotensin II; APD; action potential duration; β1-AR; β1-adrenergic receptors; CABIN-1; calcineurin binding protein 1; Carabin; TBC1 domain family member 10C; CHP; calcine
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
Keywords: GJ; Gap junction; Cx; Connexin; GJIC; GJ intercellular communication; PKA; cAMP-Dependent protein kinase; AKAP; A-kinase anchoring protein; AKB; A-kinase binding domain; ERM; Ezrin, radixin, moesin; hCG; Human chorion gonadotropin; ZO-1; Zonula occludens-
Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology
Keywords: PKA; cyclic-AMP dependent protein kinase/protein kinase A; cAMP; 3â²,5â²-cyclic adenosine monophosphate; ATP; adenosine 5-triphosphate; C subunits; catalytic subunits; R subunits; regulatory subunits; AKAP; A-kinase anchoring protein; AGC group of kinas
Invited reviewMRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease
Keywords: ABC; ATP-binding cassette; AC; adenylate cyclase; AKAP; A-kinase anchoring protein; AR; adenosine receptor; CABG; coronary artery bypass graft; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; COX; cyclooxygenase; δ-SPD; δ-sto
VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome
Keywords: AKAP; A-kinase anchor protein; ALS; Amyotrophic Lateral Sclerosis; CERT; ceramide transfer protein; ER; endoplasmic reticulum; ERAD; ER-associated destruction; FFAT; two phenylalanines in an acidic tract; MSP; major sperm protein; ORP; OSBP-related protei
Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness
Keywords: Neutrophil; β2-agonist; cyclic AMP; exchange protein directly activated by cyclic AMP; hospital-acquired infection; AKAP; A kinase anchoring protein; BALTI-2; Beta Agonist Lung Injury Trial-2; cAMP; Cyclic AMP; EPAC; Exchange protein directly activated b
Type II PKAs are anchored to mature insulin secretory granules in INS-1 β-cells and required for cAMP-dependent potentiation of exocytosis
Keywords: Pancreatic; Endocrine; Insulin; Exocytosis; Potentiation; Protein kinase-A; cAMP; Compartmentalization; AKAP; A-Kinase anchoring protein; Epac; Exchange proteins directly activated by cAMP; GEF; Guanine nucleotide exchange factor; GLP-1; Glucagon-like pep
Ca2Â +/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function
Keywords: Heart; Sinoatrial node pacemaker cells; Phosphodiesterase Type 1A; Calcium; cAMP; AC; adenylyl cyclase; AKAP; A-kinase-anchoring protein; AP; action potential; CaM; calmodulin; CaMKII; calmodulin-dependent protein kinase II; Cav-3; caveolin-3; FRET; fluor
Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics
Keywords: AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; AKAP; A-kinase anchor protein; AMP; 5â² adenosine monophosphate; AMPK; AMP-activated protein kinase; Arfgap1; ADP-ribosylation factor GTPase-activating protein 1; Arhgef2; Rho guanine nucleotide ex
FRET biosensors reveal AKAP-mediated shaping of subcellular PKA activity and a novel mode of Ca2Â +/PKA crosstalk
Keywords: AKAP; A-Kinase Anchoring Protein; AKAR3; A-Kinase activity reporter 3; β2AR; β2-adrenergic receptor; [Ca2 +]i; intracellular calcium concentration; CaM; calcium-calmodulin; cAMP; cyclic adenosine monophosphate; CB4; calmodulin binding domain 4; CFP; cy
Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics
Keywords: 3D lrECM; three-dimensional cultures of laminin-rich extracellular matrix; ACs; adenylyl cyclases; AKAP; A-kinase anchoring protein; ATP; adenosine triphosphate; β-AR; β adrenergic receptor; β-arr2; β-arrestin 2; BnT; benzylthio group; cAB; cAMP-bindi
GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation
Keywords: GSKIP; AKAP; GSK3; Drp1; Anchoring; Mitochondrial morphology;
Study of PTEN subcellular localization
Keywords: AKAP; A kinase anchoring protein; ArA; arachidonic acid; Ca2+; calcium; CLS; cytoplasmic localization signal; Co-IP; co-immunoprecipitation; COX; cytochrome c oxidase; ER; endoplasmic reticulum; ER-RFP; endoplasmic reticulum-targeted red fluorescent prote
Key role of phosphodiesterase 4A (PDE4A) in autophagy triggered by yessotoxin
Keywords: AKAP; A-kinase anchoring proteins; Bcl-2; B-cell lymphoma 2 anti-apoptotic protein; BSA; bovine serum albumin; C and R; catalytic and regulatory regions; cAMP; adenosine 3â²,5â²-cyclic monophosphate; Cav-1; caveolin-1; CREB; cAMP response element bindin
UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy
Keywords: PDEs; phosphodiesterases; AKAP; A-kinase anchoring protein; cAMP; 3â²,5â²-cyclic monophosphate; Epac; exchange protein directly activated by cAMP; PKA; protein kinase A; PKC; protein kinase C; PKD; protein kinase D; UCR; upstream conserved region; β-AR
Mitochondria: A kinase anchoring protein 1, a signaling platform for mitochondrial form and function
Keywords: AKAP; A kinase anchoring protein; BAD; Bcl-2-associated death promoter; cAMP; cyclic AMP; CaN; calcineurin; Casp; caspase; Drp1; dynamin-related protein 1; Fo-f; ATP synthase Fo complex; HIF-1a; hypoxia induced factor 1a; KH; K homology; LPL; lipoprotein
Associate Editor: P. HolzerHow anchoring proteins shape pain
Keywords: Accessory protein; AKAP; Pain; Scaffolding protein; Sensitisation; AKAP; A-kinase anchoring protein; AMPA; 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid; ASIC; Acid-sensing ion channel; cAMP; Cyclic adenosine monophosphate; CaV1.2; L-type vol
Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in can
Keywords: luteolin; 3â²,4â²,5,7-tetrahydroxyflavone; IFN; interferon; JAK; Janus kinase; STAT; signal transducer and activator of transcription; ISRE; interferon α-stimulated response element; PDE; phosphodiesterase; cAMP; cyclic adenosine 3â²,5â²-monophosphat
Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling
Keywords: 5-HT; 5-hydroxytryptamine; AKAP; A-kinase anchoring protein; DMSO; dimethyl sulfoxide; GRK; G protein-coupled receptor kinase; HEK293; human embryonic kidney cell line; IBMX; isobutylmethylxanthine; IP; immunoprecipitation; PDE; phosphodiesterase; PKA; pr
Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state
Keywords: AKAP; A-kinase anchor proteins; Akt; protein kinase B; CREB; cAMP response element-binding protein; HT; hydroxytyrosol; NHDF-neo; neonatal normal human dermal fibroblasts; NRF1; nuclear respiratory factor 1; OXPHOS; oxidative phosphorylation system; PGC-1
A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in cardiac fibroblasts
Keywords: GTP; guanosine triphosphate; AKAP; A-kinase anchoring protein; GEF; guanine nucleotide exchange factor; AT1Rs; type I angiotensin II receptors; sh; short hairpin; ECM; extracellular matrix; α-SMA; α-smooth muscle actin; TGF-β; transforming growth facto
Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease
Keywords: LRRK2; Parkinson's disease; Kinase; GTPase; Inhibitor; Endocytosis; Autophagy; Vesicle trafficking; Neuronal dysfunction; Rab protein; AKAP; A-kinase anchoring protein; ANK; ankyrin repeat; AP; adaptor protein; ARM; armadillo repeat; CHIP; carboxyl termin
Systems biology of synaptic plasticity: A review on N-methyl-d-aspartate receptor mediated biochemical pathways and related mathematical models
Keywords: AC; adenylyl cyclase; AKAP; A-kinase anchoring protein; AMPAR; A-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; CaM; calmodulin; CaMKII; Ca2+/CaM-dependent protein kinase II; cAMP; cyclic adenosine monophosphate; HFS; high frequency stimula
Annexins - Scaffolds modulating PKC localization and signaling
Keywords: AKAP; A-kinase-anchoring protein; Anx; annexin; Ca2Â +; calcium; DAG; diacylglycerol; EGFR; epidermal growth factor receptor; HSP; heat shock protein; IP3; inositol triphosphate; MAPK; mitogen-activated protein kinase; PI(4,5)P2; phosphoinositide 4,5-biph
Post-translational modification of mitochondria as a novel mode of regulation
Keywords: Abl; Abelson murine leukemia viral oncogene homolog 1; AKAP; A-kinase anchoring protein; DUB; deubiquitinating enzymes; FAO; fatty acid oxidation; GCN5L1; GCN5-like 1; IMM; inner mitochondrial membrane; IMS; intermembrane space; MEFs; mouse embryonic fibr
Increased density of AKAP5-expressing neurons in the anterior cingulate cortex of subjects with bipolar disorder
Keywords: A kinase anchor protein (AKAP) 5/79; Bipolar disorder; Prefrontal cortex; Immunohistochemistry; Stereology; ACC; Anterior Cingulate Cortex; AKAP; A-Kinase Anchor(ing) Protein; AMPA; α-Amino-3-hydroxy-5-Methyl-4-isoxazolepropionic Acid; BD; Bipolar Disord
Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes
Keywords: mAKAP; Muscle Specific A-Kinase anchoring Protein; MEF2; Myocyte Enhancer Factor 2; CaN; Calcineurin; CaNBD; Calcineurin Binding Domain; Scaffold; AKAP; Protein phosphatase; Calcineurin; MEF2;
Src kinases are important regulators of mitochondrial functions
Keywords: OXPHOS; oxidative phosphorylation; ETS; electron transport system; PKA; cAMP-dependent protein kinase; ROS; reactive oxygen species; Y; tyrosine; MEF; mouse embryonic fibroblasts; ER; endoplasmic reticulum; PKCδ; protein kinase C δ; RBM; rat brain mitoc
Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA
Keywords: 7-TM; seven transmembrane domain; AC; adenylate cyclase; AKAP; A-kinase anchoring protein; Bnz-cAMP; N6-benzoyl-cAMP; 8-CPT; 8-CPT-2-Me-cAMPS; cGCPs; cerebellar granule cell progenitors; IBMX; isobutylmethylxanthine; FSK; forskolin; GliA; Gli activator; G
Identification of voltage-gated K+ channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1)
Keywords: AKAP; A kinase anchor protein; ATP; adenosine tris-phosphate; BSA; bovine serum albumin; cDNA; complementary deoxyribonucleic acid; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; CHO; Chinese hamster ovary; CGRP; calcitonin gene-related