دانلود مقالات ISI درباره آکت + ترجمه فارسی

Ecdysteroidogenesis and development in Heliothis virescens (Lepidoptera: Noctuidae): Focus on PTTH-stimulated pathways

Keywords: آکت; PG; prothoracic gland; BE; brain equivalent; PTTH; prothoracicotropic hormone; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; Akt; protein kinase B; TOR; target of rapamycin; EIA; enzyme immunoassay; 4E-BP; translational represso

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Cannabidiol induced apoptosis in human monocytes through mitochondrial permeability transition pore-mediated ROS production

Keywords: آکت; AKT; Protein kinase B; Bcl-2; B-cell lymphoma 2; calcein-AM; calcein-acetoxymethylester; CBD; cannabidiol; CM-H2DCF-DA; 5,6-chloromethyl-2,7-dichlorodihydrofluorescin diacetate; COX IV; cytochrome c oxidase subunit IV; CsA; cyclosporin A; Cyt c; cytochrom

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment

Keywords: آکت; 7TMR; seven transmembrane receptor; Akt; protein kinase B; APJ; apelin receptor; βarr; β-arrestin; BRET; bioluminescence resonance energy transfer; cAMP; cyclic adenosine monophosphate; ERK1/2; extra-cellular regulated kinase 1/2; GPCR; G protein-couple

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheime

Keywords: آکت; Alzheimer's; Aβ; Phospho-tau; Beta-secretase; Atypical PKC; PKC-iota/lambda; PKM-zeta; Insulin; Metformin; Akt;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Keywords: آکت; Autophagy; Combination therapy; Erlotinib; Vps34; High-content screening; AKT; Protein kinase B; ATG7; Autophagy-related protein 7; BafA1; Bafilomycin A1; Chk1; Checkpoint kinase 1; CQ; Chloroquine; FGFR; Fibroblast growth factor receptor; GFP; Green fluo

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation

Keywords: آکت; Cytotoxicity; PIKfyve; Ppilimod; YM201636; AKT; MK-2206;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells

Keywords: آکت; STX3; Breast cancer; PTEN; PI3K; Akt; mTOR;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Transcriptome analysis reveals novel insights into the response of low-dose benzo(a)pyrene exposure in male tilapia

Keywords: آکت; TGFi; TGF induced factor homeobox; TGF; transforming growth factor; IL1; interleukin 1; IL1i; IL1 inhibitors; IL1RL1; interleukin 1 receptor like 1; TNF; tumor necrosis factor; Nogo; reticulon 4 (RTN4/Nogo); NGF; nerve growth factor; STC; stanniocalcin 1;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells

Keywords: آکت; Adenosine receptors; Neuroregeneration; Glaucoma; Akt; 2-Cl-IB-MECA; IOP; intraocular pressure; RGC; retinal ganglion cell; NTG; normal tension glaucoma; AC; adenylyl cyclase; cAMP; cyclic adenosine monophosphate; PI3K; phosphoinositide 3-kinase; AdoR; ad

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway

Keywords: آکت; Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model

Keywords: آکت; AKT; ATXN1: ataxin-1 protein; iPSC; induced pluripotent stem cell; MSK1/2; mitogen- and stress-activated kinases 1 and 2; PKA; cyclic AMP-dependent protein kinase; SCA1; Spinocerebellar ataxia type 1; SCA1; Purkinje cells; Ataxia; Phosphorylation; ATXN1-S

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

FLCN: The causative gene for Birt-Hogg-Dubé syndrome

Keywords: آکت; AEC; alveolar epithelial type II cell; AKT; protein kinase B; AMPK/Ampk; 5′-AMP activated protein kinase; AMPKα (also AAK-2); AMPKα subunit; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; BHD; Birt-Hogg-Dubé; BAT; brown adipose tissue; C. ele

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

Signaling pathways activated by PACAP in MCF-7 breast cancer cells

Keywords: آکت; PACAP; MCF-7; p38; ERK1/2; AKT; ROS; Cancer; Signal transduction;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2018 سفارش ترجمه

Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling

Keywords: آکت; AKT; protein kinase B; AMP; Antimicrobial peptide; AMPK; AMP-activated protein kinase; CaMKKβ; Ca2+/calmodulin-dependent protein kinase kinase beta; CWA; Cathelicidin-WA; ERK; extracellular regulated protein kinase; HO-1; hemeoxygenase-1; IL-6; interleuk

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Polyglutamine expansion diseases: More than simple repeats

Keywords: آکت; Neurodegenerative disease; Polyglutamine protein; Aggregation modulation; Post-translational modification; Molecular partner; Ataxin-3; APR; aggregation-prone region; αB-c; AlphaB-crystallin; AR; androgen receptor; Atx1; ataxin-1; Atx3; ataxin-3; Atn1; a

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

15-Deoxy-Δ12,14-prostaglandin J2 activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136

Keywords: آکت; Akt; Cyclopentenone prostaglandins; 15-Deoxy-Δ12,14-prostaglandin J2; PTEN; Thiol modification;

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation

Keywords: آکت; ABL; Abelson murine leukemia viral oncogene homolog 1; ALIS; aggresome-like induced structure; ALL; acute lymphoblastic leukemia; BCR; breakpoint cluster region; CML; chronic myeloid leukemia; DCFH-DA; 2′, 7′-dichlorodihydrofluorescein diacetate; DCPI

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

Heteromultivalent targeting of integrin αvβ3 and neuropilin 1 promotes cell survival via the activation of the IGF-1/insulin receptors

Keywords: آکت; Angiogenesis; Silica nanoparticles; αvß3 integrin; VEGFR2 antagonist; AKT; IGF-1R/IR; Homomultimer and heteromultimer targeting;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors

Keywords: آکت; Apoptosis; Akt; Benzothiazole; Cancer; FAK; Oxadiazole; Thiazole;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

Keywords: آکت; PI3K; AKT; mTOR; Inhibitors; Targeted therapy; Immunotherapy; Combination therapy; Tumor microenvironment; Immunotherapeutic resistance;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease

Keywords: آکت; mGlu; Metabotropic glutamate receptor; PD; Parkinson's disease; T10; Triptolide; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; TNF; tumor necrosis factor; IL; interleukin; SN; substantia nigra; COX; cyclooxygenase; JN

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Keywords: آکت; Epilepsy; Rapamycin; Everolimus; Pharmacokinetics; Tolerability; Levetiracetam; AKT; protein kinase B; ASD; anti-seizure drug; 4E-BP1; initiation factor 4E binding protein; HPβCD; hydroxypropyl-ß-cyclodextrin; MTD; maximal tolerated dose; MES-T; maximal

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

The connexin 43 C-terminus: A tail of many tales

Keywords: آکت; Akt; protein kinase B; CCN; CYR61/connective tissue growth factor/nephroblastoma overexpressed; CDK1; cyclin-dependent kinase 1; CIP75; Cx43-interacting protein of 75 kDa; CIP85; Cx43-interacting protein of 85-kDa; CK1; casein kinase 1; Csk; C-terminal c

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin-dependent function in human eosinophils

Keywords: آکت; Eosinophil; Siglec-8; β2-integrin; apoptosis; phosphoproteomics; reduced nicotinamide adenine dinucleotide phosphate oxidase (NADPH); p38; c-Jun N-terminal kinase (JNK); Akt; DAPI; 4′-6-Diamidino-2-pheynlindole dihydrochloride; DAVID; Database for Anno

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Impairment of learning and memory performances induced by BPA: Evidences from the literature of a MoA mediated through an ED

Keywords: آکت; Bisphenol A; Endocrine disruption; Learning and memory; Nervous system; 5α-R; 5 α-reductase; AChE; acetylcholinesterase; Akt; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANSES; Agence Nationale de Sécurité Sanitaire

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2018 سفارش ترجمه

Atorvastatin impaired glucose metabolism in C2C12 cells partly via inhibiting cholesterol-dependent glucose transporter 4 translocation

Keywords: آکت; ABC; ATP-binding cassette; Akt; Protein kinase B; AUC; area under the concentrationtime curve; BW; body weight; CMC; carboxyl methyl cellulose; ERK; extracellular-regulated protein kinase; GCK; glucokinase; GLUT2; glucose transporter 2; GLUT4; glucose tra

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization

Keywords: آکت; 3-MA; 3-Methyl Adenine; Akt; Protein kinase B; AMP; Adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; Autophagy related genes; ATP; Adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; BCL-2; B-

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

Dueling for dual inhibition: Means to enhance effectiveness of PI3K/Akt/mTOR inhibitors in AML

Keywords: آکت; AML; mTOR; PI3K; Akt; Resistance mechanisms; Dual inhibitors; Rapalogs;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

The next generation of PI3K-Akt-mTOR pathway inhibitors in breast cancer cohorts

Keywords: آکت; Breast Cancer; PI3K/AKT/mTOR pathway; PI3K; AKT; mTOR; Clinical Trials;

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

Keywords: آکت; Akt; oncogene in the transforming retrovirus, AKT8; AP-1; activator protein 1; ARAF; v-raf murine sarcoma 3611 viral oncogene homologue; ASK1; apoptosis signal-regulating kinase 1; BCL2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma extra large; BRAF; v-raf

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy in ischemic stroke

Keywords: آکت; 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5′-triphosphate; BBB; blood-brain ba

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical benefits and pharmacology of scutellarin: A comprehensive review

Keywords: آکت; Aβ; β-amyloid peptide; ACE; angiotensin-converting enzyme; AD; Alzheimer's disease; ADE; adverse drug effect; ADR; adverse drug reaction; AIF; apoptosis-inducing factor; Akt; protein kinase B or PKB; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activat

دانلود رایگان متن کامل مقاله ISI 116 صفحه سال انتشار : 2018 سفارش ترجمه

Isoquinoline alkaloids from Coptis japonica stimulate the myoblast differentiation via p38 MAP-kinase and Akt signaling pathway

Keywords: آکت; Coptis japonica; Isoquinoline alkaloid; Myoblast differentiation; MyoD; p38 MAPK; Akt;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of AKT activity prevents autonomic nervous system imbalance

Keywords: آکت; AKT; Autonomic nervous system; FoxO; Loneliness stress; Spontaneous motility;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) ameliorated dexamethasone induced hepatic gluconeogenesis through activation of Akt/FoxO1 pathway

Keywords: آکت; K145; SphK2; Hepatic gluconeogenesis; Akt;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Preclinical Evaluation of MET Inhibitor INC-280 With or Without the Epidermal Growth Factor Receptor Inhibitor Erlotinib in Non-Small-Cell Lung Cancer

Keywords: آکت; Acquired resistance; AKT; Combination therapy; EGFR mutant; ERK;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibitory effect of 5-iodotubercidin on pigmentation

Keywords: آکت; 5-Iodotubercidin; Pigmentation; CREB; AKT; ERK; Zebrafish;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK and EMT related signals in hepatocellular carcinoma cells

Keywords: آکت; N-trans-feruloyloctopamine (FO); AKT; MAPK; E-cadherin; Epithelial to mesenchymal transition (EMT); Hepatocellular carcinoma;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Matrine inhibits bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway: An experimental study

Keywords: آکت; Bladder cancer; Matrine; PI3K; AKT; Proliferation; Invasion;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperCXCR6 promotes tumor cell proliferation and metastasis in osteosarcoma through the Akt pathway

Keywords: آکت; CXCR6; Akt; Proliferation; Invasion; Osteosarcoma;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet

Keywords: آکت; Adipocyte number; Adipogenesis; Glucose tolerance; Phytol; PI3K/Akt; Mice; Akt; protein kinase B; aP2; adipocyte protein 2; AS160; Akt substrate of 160 kDa; AUC; area under the curve; C/EBPα; CCAAT-enhancer-binding proteins; FoxO1; Forkhead box protein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway

Keywords: آکت; S1PR2; High glucose; Mitochondrial apoptosis; Akt; GSK-3β;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Mild hypothermia pretreatment protects hepatocytes against ischemia reperfusion injury via down-regulating miR-122 and IGF-1R/AKT pathway

Keywords: آکت; Mild hypothermia pretreatment; microRNA-122; Ischemia reperfusion; IGF-1R; AKT;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Dual hypopigmentary effects of punicalagin via the ERK and Akt pathways

Keywords: آکت; α-MSH; α-melanocyte-stimulating hormone; ERK; extracellular signal-regulated kinase; GSK3β; glycogen synthase kinase3β; MITF; microphthalmia-associated transcription factor; Akt; ERK; Melanogenesis; MITF; Punicalagin; Tyrosinase;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Antagonist of thromboxane A2 receptor by SQ29548 lowers DOCA-induced hypertension in diabetic rats

Keywords: آکت; Thromboxane A2 receptor; Diabetes; Akt; eNOS; Hypertension;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Activation of Akt and the signaling of phosphorylated Akt in the L5 dorsal root ganglia in aging rats

Keywords: آکت; Aging; Akt; Dorsal root ganglia; Satellite glial cell;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Oxaloacetate and adipose stromal cells-conditional medium synergistically protected potassium/serum deprivation-induced neuronal apoptosis

Keywords: آکت; Oxaloacetate; Adipose stromal cells; Neuronal apoptosis; Caspase-3; Akt; JNK; Neuroprotection;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes

Keywords: آکت; Antagonism; AKT; BRAF; Dabrafenib; Sorafenib;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Oligomeric proanthocyanidin derived from grape seeds inhibited NF-κB signaling in activated HSC: Involvement of JNK/ERK MAPK and PI3K/Akt pathways

Keywords: آکت; Oligomeric proanthocyanidin; Hepatic stellate cell; MAPK; PI3K; Akt;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2)

Keywords: آکت; Oxidative stress; Reactive oxygen species; Peroxiredoxin-3; Mammalian target of rapamycin (mTORC2); Rictor; Insulin resistance; Akt; Adipocytes;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه