دانلود مقالات ISI درباره آلک + ترجمه فارسی

Treatment, outcome and quality of life of 1239 patients with advanced non-small cell lung cancer - final results from the prospective German TLK cohort study

Keywords: آلک; ALK; Anaplastic Lymphoma Kinase; BMI; body mass index; CCI; Charlson Comorbidity Index; CI; confidence interval; CR; complete response; CRISP; clinical research platform into molecular testing, treatment and outcome of non-small cell lung carcinoma patien

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

CAR T-cell therapy for lung cancer and malignant pleural mesothelioma

Keywords: آلک; ACT; adoptive cell therapy; ADC; adenocarcinoma; ALK; anaplastic lymphoma kinase; CAF; cancer-associated fibroblast; CAR; chimeric antigen receptor; CEA; carcinoembryonic antigen; CTLA-4; cytotoxic T-lymphocyte associated protein 4; DNR; dominant negative

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis

Keywords: آلک; Neuroblastoma; Chemotherapy; YK-4-279; Mitosis; Drug resistance/synergy; ALK; Anaplastic Lymphoma kinase; EGF; Epidermal growth factor; ERK; extracellular signal-regulated kinases; GFP; green fluorescent protein; kDa; kilodaltons; MAPK; mitogen-activated

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Correlation between Classic Driver Oncogene Mutations in EGFR, ALK, or ROS1 and 22C3-PD-L1 ≥50% Expression in Lung Adenocarcinoma

Keywords: آلک; Lung cancer; PD-L1; PD-1; Pembrolizumab; EGFR; ALK;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

PD-L1 expression in advanced NSCLC: Insights into risk stratification and treatment selection from a systematic literature review

Keywords: آلک; ALK; anaplastic lymphoma kinase; CI; confidence interval; ECOG; The Eastern Cooperative Oncology Group; DCB; durable clinical benefit; DCR; disease control rate; EGFR; epidermal growth factor receptor; EGFRm+; EGFR mutation positive; FDA; Food and Drug Ad

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Combinational Analysis of FISH and Immunohistochemistry Reveals Rare Genomic Events in ALK Fusion Patterns in NSCLC that Responds to Crizotinib Treatment

Keywords: آلک; ALK; Fluorescence in situ hybridization; Immunohistochemistry; Discordant cases; Complicated rearrangement;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Detection of ALK and KRAS Mutations in Circulating Tumor DNA of Patients With Advanced ALK-Positive NSCLC With Disease Progression During Crizotinib Treatment

Keywords: آلک; ALK; Circulating cell-free DNA; Crizotinib-resistance; KRAS; NSCLC;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

F1174V mutation alters the ALK active conformation in response to Crizotinib in NSCLC: Insight from molecular simulations

Keywords: آلک; NSCLC; ALK; Crizotinib; Molecular dynamic; F1174V mutation;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Biomarker Development in COPD

Keywords: آلک; biomarkers; COPD; personalized medicine; ALK; anaplastic lymphoma kinase; CRP; C-reactive protein; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; NSCLC; non-small cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Real-World EQ5D Health Utility Scores for Patients With Metastatic Lung Cancer by Molecular Alteration and Response to Therapy

Keywords: آلک; ALK; EGFR; HUS; NSCLC; SCLC;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Leptomeningeal carcinomatosis in non-small cell lung cancer patients: A continuing challenge in the personalized treatment era

Keywords: آلک; Neoplastic; Meningitis; Lung; Intrathecal; EGFR; ALK; Metastasis;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of a potent dual ALK and EGFR T790M inhibitor

Keywords: آلک; ALK; EGFR T790M; Dual inhibitor; Non-small cell lung cancer; Rational drug design;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Effectiveness of crizotinib in a patient with ALK IHC-positive/FISH-negative metastatic lung adenocarcinoma

Keywords: آلک; ALK; Crizotinib; Fluorescent in situ hybridization; Immunohistochemistry; Non-small-cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Clinical approach of intratumoral heterogeneity in lung adenocarcinoma. Two clinical cases with changing somatic driver mutations

Keywords: آلک; EGFR; KRAS; ALK; Intratumoral heterogeneity; Biomarker;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Neoadjuvant Oncogene-Targeted Therapy in Early Stage Non-Small-Cell Lung Cancer as a Strategy to Improve Clinical Outcome and Identify Early Mechanisms of Resistance

Keywords: آلک; Acquired resistance; ALK; Clinical trial; Crizotinib; EGFR; MET exon 14; Neoadjuvant treatment; NSCLC; ROS1;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Neuroendocrine phenotype as an acquired resistance mechanism in ALK-rearranged lung adenocarcinoma

Keywords: آلک; Non-small cell lung carcinoma; Adenocarcinoma; ALK; Crizotinib; Neuroendocrine;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

ALK-positive inflammatory myofibroblastic tumor harboring ALK gene rearrangement, occurring after allogeneic stem cell transplant in an adult male

Keywords: آلک; Inflammatory myofibroblastic tumor; Stem cell transplant; ALK; Molecular analysis; Fluorescence in situ hybridization; Lymphoblastic lymphoma;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Alectinib Dose Escalation Reinduces Central Nervous System Responses in Patients with Anaplastic Lymphoma Kinase–Positive Non–Small Cell Lung Cancer Relapsing on Standard Dose Alectinib

Keywords: آلک; Alectinib; ALK; Anaplastic lymphoma kinase; Leptomeningeal metastases

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Antibody 1A4 with routine immunohistochemistry demonstrates high sensitivity for ALK rearrangement screening of Chinese lung adenocarcinoma patients: A single-center large-scale study

Keywords: آلک; ALK; 1A4; D5F3; FISH; Immunohistochemistry; Lung adenocarcinoma;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Case reportTFE3-positive renal cell carcinomas are not always Xp11 translocation carcinomas: Report of a case with a TPM3-ALK translocation

Keywords: آلک; Renal cell carcinoma; Translocation carcinoma; Fish; Immunohistochemistry; TFE3; ALK;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Alkylphloroglucinol derivatives and triterpenoids with soluble epoxide hydrolase inhibitory activity from Callistemon citrinus

Keywords: آلک; gallomyrtucommulone A (PubChem CID: 11505110); endoperoxide G3 (PubChem CID: 11207902); betulinic acid (PubChem CID: 64971); diospyrolide (PubChem CID: 3037455); ursolic acid (PubChem CID: 64945)Soluble epoxide hydroxylase (sEH); Callistemon citrinus; Alk

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

De novo ALK kinase domain mutations are uncommon in kinase inhibitor-naïve ALK rearranged lung cancers

Keywords: آلک; Mutation; Lung cancer; Adenocarcinoma; ALK; Kinase domain; Crizotinib;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Stratégie de testing moléculaire des carcinomes pulmonaires

Keywords: آلک; Cancer du poumon; EGFR; ALK; KRAS; ROS1; Algorithme de test; Biopsie; Lung cancer; EGFR; ALK; KRAS; ROS1; Algorithm of testing; Biopsy;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Feasibility of cytological specimens for ALK fusion detection in patients with advanced NSCLC using the method of RT-PCR

Keywords: آلک; NSCLC; ALK; Cytological specimens; RT-PCR; Crizotinib

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular dynamics simulations reveal the allosteric effect of F1174C resistance mutation to ceritinib in ALK-associated lung cancer

Keywords: آلک; ALK; Drug-resistance mutation; MD simulations; MM/GBSA; Allostery; P-loop;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

MicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth factor receptor mutations or anaplastic lymphoma kin

Keywords: آلک; miRNAs; microRNAs; EGFR; epidermal growth factor receptor; ALK; anaplastic lymphoma kinase; RT-PCR; Reverse Transcription-Polymerase Chain Reaction; PFS; progression-free survival; NSCLC; Non-small cell lung cancer; OS; Overall survival; CI; confidence in

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Clinicopathologic Features of NSCLC Diagnosed During Pregnancy or the Peripartum Period in the Era of Molecular Genotyping

Keywords: آلک; Pregnancy; ALK; EGFR; Lung cancer;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors

Keywords: آلک; ALK; Kinase; Anti-tumor; NSCLC; Pyrimidine;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Resistance mechanisms after tyrosine kinase inhibitors afatinib and crizotinib in non-small cell lung cancer, a review of the literature

Keywords: آلک; EGFR; ALK; Targeted therapy; Crizotinib resistance; Afatinib resistance; NSCLC;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Assessment of chemotherapy strategy using bevacizumab for non-squamous non-small cell lung cancer in a real-world setting: A multi-institutional observational study

Keywords: آلک; ALK; Anaplastic Lymphoma Kinase; BEV; Bevacizumab; BBP; Bevacizumab Beyond Progression; CBDCA; Carboplatin; CDDP; Cisplatin; CI; Confidence Interval; EGFR; Epidermal-growth Factor Receptor; EGFR-TKI; Epidermal-growth Factor Receptor Tyrosine Kinase Inhibi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Actualités sur les thérapies ciblées dans les cancers bronchiques non à petites cellules, hors immunothérapie

Keywords: آلک; Cancer bronchique non à petites cellules; EGFR; Mutation T790M; ALK; ACSé; Non-small cell lung cancer; EGFR; T790M resistance mutation; ALK; ACSé;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Custom Gene Capture and Next-Generation Sequencing to Resolve Discordant ALK Status by FISH and IHC in Lung Adenocarcinoma

Keywords: آلک; Lung; ALK; Discordant; FISH; IHC; NGS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Common pathways regulate Type III TGFβ receptor-dependent cell invasion in epicardial and endocardial cells

Keywords: آلک; βArr2; beta-arrestin2; ALK; activin receptor-like kinases; AV; atrioventricular; BMP; bone morphogenetic protein; ca; constitutively active; EMT; Epithelial-Mesenchymal Transformation; FGF; fibroblast growth factor; GFP; green fluorescent protein; GIPC

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Synergistic Activation upon MET and ALK Coamplification Sustains Targeted Therapy in Sarcomatoid Carcinoma, a Deadly Subtype of Lung Cancer

Keywords: آلک; MET; ALK; FISH; Sarcomatoid carcinoma; Lung; Survival;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

VIP and PACAP analogs regulate therapeutic targets in high-risk neuroblastoma cells

Keywords: آلک; MYCN; ALK; AKT; PKA; Invasion; Differentiation;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewLung cancer mutation profile of EGFR, ALK, and KRAS: Meta-analysis and comparison of never and ever smokers

Keywords: آلک; Lung cancer; Never smokers; EGFR; ALK; KRAS; Mutation;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors

Keywords: آلک; ALK; Cancer; NSCLC; LDK378; Tetrahydroisoquinoline (THIQ)

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Drastic initial response and subsequent response to two ALK inhibitors in a patient with a highly aggressive ALK-rearranged inflammatory myofibroblastic tumor arising in the pleural cavity

Keywords: آلک; Inflammatory myofibroblastic tumor; ALK; ASP3026; Ceritinib; NF1; Hyaluronan;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2016 سفارش ترجمه

A Phase III Study of Durvalumab (MEDI4736) With or Without Tremelimumab for Previously Treated Patients With Advanced NSCLC: Rationale and Protocol Design of the ARCTIC Study

Keywords: آلک; Anti-CTLA-4; Anti-PD-L1; ALK; EGFR; Tumor membrane staining;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

Comparative Efficacy of Ceritinib and Crizotinib as Initial ALK-Targeted Therapies in Previously Treated Advanced NSCLC: An Adjusted Comparison with External Controls

Keywords: آلک; ALK; NSCLC; ceritinib; crizotinib; indirect comparison;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

Recurrence of anaplastic lymphoma kinase (ALK) positive adenocarcinoma after 17 years: Case report

Keywords: آلک; NSCLC; ALK; Outcome; Stage one; Relapse;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

A Novel, Highly Sensitive ALK Antibody 1A4 Facilitates Effective Screening for ALK Rearrangements in Lung Adenocarcinomas by Standard Immunohistochemistry

Keywords: آلک; Lung adenocarcinoma; ALK; Immunohistochemistry; Antibody 1A4; Routine diagnostics;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers

Keywords: آلک; Lung cancer; NSCLC; Brain metastases; EGFR; ALK; Mutation; Rearrangement; Central nervous system; CNS;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Alectinib Salvages CNS Relapses in ALK-Positive Lung Cancer Patients Previously Treated with Crizotinib and Ceritinib

Keywords: آلک; ALK; Anaplastic lymphoma kinase; Leptomeningeal metastases; Alectinib;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Responses to the multitargeted MET/ALK/ROS1 inhibitor crizotinib and co-occurring mutations in lung adenocarcinomas with MET amplification or MET exon 14 skipping mutation

Keywords: آلک; Mutation; Lung cancer; Adenocarcinoma; MET; Exon 14; Amplification; PIK3CA; ALK; ROS1; Crizotinib; Ceritinib;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Automation of ALK gene rearrangement testing with fluorescence in situ hybridization (FISH): A feasibility study

Keywords: آلک; Fluorescence in situ hybridization; FISH; VP 2000; Automation; BioView; ALK

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase

Keywords: آلک; Kinase; ALK; ALCL; NSCLC; Inhibitors; Pyrrolotriazine;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Novel ALK fusion partners in lung cancer

Keywords: آلک; Lung cancer; ALK; Translocation; Rearrangement; Fusion partner; PCR

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Clinical impact of sequential treatment with ALK-TKIs in patients with advanced ALK-positive non-small cell lung cancer: Results of a multicenter analysis

Keywords: آلک; Alectinib; ALK; ALK-TKI; Ceritinib; Crizotinib; Non-small cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of 2-arylamino-4-(1-methyl-3-isopropylsulfonyl-4-pyrazol-amino)pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors

Keywords: آلک; ALK; Kinase inhibitor; NSCLC; PK properties; Antitumor efficacy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه