Activation of the Activin A-ALK-Smad pathway in systemic sclerosis
Keywords: آلک; Systemic sclerosis; Fibroblasts; Activin; ALK;
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Research ArticleTGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells
Keywords: آلک; Hepatic stellate cells; Rho kinase; LX-2 cell line; Endothelin-1; Transforming growth factor-β; Liver fibrosis; TGF-β; transforming growth factor-β; ALK; anaplastic lymphoma kinase; HSC; hepatic stellate cells; MAP kinase; mitogen activated protein kin
Role of IN-1233 in the Prevention of Neointimal Hyperplasia after Stent Placement in a Rat Artery Model
Keywords: آلک; ALK; activin receptor-like kinase; CIA; common iliac artery; EEL; external elastic lamina; IEL; internal elastic lamina; LA; luminal area; MA; medial area; NA; neointimal area; %NH; percentage of neointimal hyperplasia; N/M; neointimal-to-medial area ra
Detection of ALK Gene Rearrangement in Non-small Cell Lung Cancer: A Comparison of Fluorescence In Situ Hybridization and Chromogenic In Situ Hybridization with Correlation of ALK Protein Expression
Keywords: آلک; Lung cancer; ALK; Fluorescence in situ hybridization; Chromogenic in situ hybridization
Clinicopathologic Characteristics and Outcomes of Patients with Anaplastic Lymphoma Kinase-Positive Advanced Pulmonary Adenocarcinoma: Suggestion for an Effective Screening Strategy for These Tumors
Keywords: آلک; Lung; Adenocarcinoma; ALK; EGFR; TTF-1
Emerging importance of ALK in neuroblastoma
Keywords: آلک; Neuroblastoma; ALK; Tyrosine kinase receptor; Targeted therapy; Crizotinib; Drug resistance; Point mutations; Small molecule inhibitors; Combination treatment
Functional interaction of fibroblast growth factor-8, bone morphogenetic protein and estrogen receptor in breast cancer cell proliferation
Keywords: آلک; ActRI and ActRII; activin type-I and -II receptor; ALK; activin receptor-like kinase; Arom; aromatase; BMP; bone morphogenetic protein; BMPRI and BMPRII; BMP type-I and -II receptor; ER; estrogen receptor; ERK; extracellular signal-regulated kinase; FGF;
Community effect triggers terminal differentiation of myogenic cells derived from muscle satellite cells by quenching Smad signaling
Keywords: آلک; BMP, bone morphogenetic protein; ALK, activin-like kinase; MyHC, myosin heavy chain; BPV, bupivacaine hydrochlorideCommunity effect; BMP; Smad; ALK; Myogenesis; Osteogenesis
Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo
Keywords: آلک; Alk; activin receptor-like kinase; CPSF; cleavage polyadenylation specificity complex; HD; Hirschsprung disease; MR; mental retardation; PAH; pulmonary arterial hypertension; PD; Parkinson disease; SIP; Smad-interacting protein; Smicl; Smad-interacting CP
Identification of Oncogenic Point Mutations and Hyperphosphorylation of Anaplastic Lymphoma Kinase in Lung Cancer
Keywords: آلک; ALK; anaplastic lymphoma kinase; NSCLC; non-small cell lung cancer; NPM-ALK; nucleophosmin-anaplastic lymphoma kinase; ALCL; anaplastic large cell lymphoma; EML4-ALK; echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase; TAE684; NVP
Biologie des cancers bronchopulmonaires
Keywords: آلک; cancers pulmonaires; biologie moléculaire; antityrosine-kinases; EGFR; Ras; ALK; adénocarcinomes; résistance; thérapeutiques ciblées; lung cancer; molecular biology; anti-tyrosinekinases; EGFR; Ras; ALK; adenocarcinomas; resistance; targeted therapy;
Primary gastric inflammatory myofibroblastic tumor: A clinicopathologic and immunohistochemical study of 5 cases
Keywords: آلک; Stomach; Inflammatory myofibroblastic tumor; Histological features; Immunohistochemistry; ALK
All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK
Keywords: آلک; ALK; ATRA; Neuroblastoma
Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling
Keywords: آلک; ActRI and ActRII; activin type-I and type-II receptor; ALK; activin receptor-like kinase; BMP; bone morphogenetic protein; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; M-CSF; macrophage-colony stimulating factor; OPC
TGFβ signaling positions the ciliary band and patterns neurons in the sea urchin embryo
Keywords: آلک; TGFbeta signaling; Neurogenesis; Ciliary band; Oral signaling; Nodal; BMP; Lefty; Smad; Alk; Urchin;
Transforming Growth Factor (TGF)-β Type I Receptor Kinase (ALK5) Inhibitor Alleviates Profibrotic TGF-β1 Responses in Fibroblasts Derived from Peyronie's Plaque
Keywords: آلک; Peyronie's Diseas; Transforming Growth Factor-Bet; ALK; SKI216; Cell Cultur;
Anaplastic Lymphoma Kinase: Role in specific tumours, and development of small molecule inhibitors for cancer therapy
Keywords: آلک; ALK; Kinase inhibitor; PF-2341066; Neuroblastoma; NSCLC; ALCL
Immunohistochemical Surrogates for Genetic Alterations of CCDN1, PML, ALK, and NPM1 Genes in Lymphomas and Acute Myeloid Leukemia
Keywords: آلک; Monoclonal antibodies; CCND1; PML; ALK; Nucleophosmin; Lymphoma; Leukemia; Immunohistochemistry
Myofibroblastic Tumors in Children
Keywords: آلک; Pediatric; Soft tissue tumors; Desmoid fibromatosis; Inflammatory myofibroblastic tumor; Familial adenomatous polyposis; Gardner syndrome; ALK; β-catenin
Lymphohistiocytic anaplastic large cell lymphoma involving skin: A diagnostic challenge
Keywords: آلک; ALK; Anaplastic large cell lymphoma; CD30-positive T-cell lymphoproliferative disorder; Granuloma; Skin cancer
Aberrant copy numbers of ALK gene is a frequent genetic alteration in neuroblastomas
Keywords: آلک; Neuroblastoma; ALK; MYCN; Copy number alterations
ALK Gene Rearrangements: A New Therapeutic Target in a Molecularly Defined Subset of Non-small Cell Lung Cancer
Keywords: آلک; ALK; Lung cancer
Expression of ALK protein, mRNA and fusion transcripts in anaplastic large cell lymphoma
Keywords: آلک; Anaplastic large cell lymphoma; ALK; Anaplastic lymphoma kinase; Fusion transcript; Immunohistochemistry; Reverse transcription polymerase chain reaction
Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non–small cell lung carcinomas
Keywords: آلک; ALK; NSCLC; FISH; EML4-ALK fusion transcript
Hyperactivated STAT3 in ALK–positive diffuse large B-cell lymphoma with clathrin-ALK fusion
Keywords: آلک; ALK; B-cell lymphoma; STAT3; STAT5; Survivin; BCL-XL
Design and synthesis of a novel tyrosine kinase inhibitor template
Keywords: آلک; Anaplastic lymphoma kinase; ALK; De novo ligand design; Kinase template synthesis; Insulin receptor kinase family; Inhibitor design
Translocations in epithelial cancers
Keywords: آلک; Translocation; Epithelial; Rearrangement; Gene fusion; Chimera; MLL; ERG; ALK; HMGA2; COPA;
An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features
Keywords: آلک; Inflammatory myofibroblastic tumor; Round cell transformation; RANBP2; ALK
A 6-Year-Old Child with Fever of Unknown Origin, Anemia, and Abdominal Pain
Keywords: آلک; ALK; Anaplastic lymphoma kinase; CT; Computed tomography; HHV; Human herpesvirus; IL; Interleukin; IMT; Inflammatory myofibroblastic tumor; MRA; Magnetic resonance angiography; MRI; Magnetic resonance imaging; PCR; Polymerase chain reaction;
Inflammatory Myofibroblastic Tumors of the Genitourinary Tract-Single Entity or Continuum?
Keywords: آلک; urinary bladder; sarcoma; soft tissue neoplasms; immunohistochemistry; carcinosarcoma; ALK; anaplastic lymphoma kinase; EBV; Epstein Barr virus; FISH; fluorescence in situ hybridization; IMT; inflammatory myofibroblastic tumor; PMP; pseudosarcomatous myof
EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas
Keywords: آلک; EML4; ALK; Fusion gene; Non-small cell lung carcinoma; p53; EGFR
Prevalence of bone marrow involvement in systemic anaplastic large cell lymphoma: are immunohistochemical studies necessary?
Keywords: آلک; Bone marrow biopsy; Anaplastic large cell lymphoma; ALK; CD30; EMA; Granzyme
Smad2 functions as a co-activator of canonical Wnt/β-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300
Keywords: آلک; Alk; activin-like kinase; EV; empty vector; EMT; epithelial-mesenchymal transition; GST; glutathione S transferase; HAT; histone acetyltransferase; SBE; Smad-binding element; TBE; Tcf/Lef-binding element; Activin; Beta-catenin; Smads; Tcf/Lef; TGF-beta;
Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension
Keywords: آلک; ALK; activin-like kinase; CR-1; Cripto-1; CFC1; Cryptic; EGF-CFC; Epidermal Growth Factor-Cripto-1/FRL-1/Cryptic; EV; empty vector; GPI; glycosylphosphatidylinositol; Cripto-1; Cryptic; EGF-CFC family protein; GPI-anchored protein; Nodal;
What to Do When You Suspect Gastrointestinal Lymphoma: A Pathologist's Perspective
Keywords: آلک; ALK; anaplastic lymphoma kinase; CHOP; cyclophosphamide, doxorubicin, vincristine, and prednisone; CT; computed tomography; DLBCL; diffuse large B-cell lymphoma; FISH; fluorescence in situ hybridization; GI; gastrointestinal; IHC; immunohistochemistry; MA
Plasma Cell Granuloma: A Case Report of Multiple Lesions in the Lung and Review of the Literature
Keywords: آلک; Granuloma; Plasma cell; Lung neoplasm; Pulmonary surgical procedures; ALK;
Anaplastic lymphoma kinase is expressed in different subtypes of human breast cancer
Keywords: آلک; PTN; RPTPβ/ζ; ALK; Breast cancer; Tumor progression
Anaplastic lymphoma kinase–positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3′ ALK gene insertion to chromosome 4 q22-24
Keywords: آلک; ALK; Diffuse large B-cell lymphoma; Cytogenetics; Fluorescence in situ hybridization (FISH); 4q22-24
Regulatory expression of bone morphogenetic protein-6 system in aldosterone production by human adrenocortical cells
Keywords: آلک; ACD; actinomycin D; ACTH; adrenocorticotropin; ALK; activin receptor-like kinase; ActRII; activin type II receptor; Ang II; angiotensin II; BMP; bone morphogenetic protein; BMPRII; BMP type II receptor; CHX; cycloheximide; ERK; extracellular signal-regula
Receptor protection studies comparing recombinant and native nicotinic receptors: Evidence for a subpopulation of mecamylamine-sensitive native α3β4* nicotinic receptors
Keywords: آلک; ALK; alkylation; brACh; bromoacetylcholine bromide; DTNB; 5â²-dithio-bis(2-nitrobenzoic acid); DTT; dithiothreitol; nAChRs; nicotinic acetylcholine receptors; PSS; physiological saline solution; Nicotinic receptors; Mecamylamine; Receptor protection assa
The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut
Keywords: آلک; Alk; Visceral mesoderm; Drosophila; Hand
Intrinsic apoptotic pathway in anaplastic large cell lymphoma
Keywords: آلک; Caspase 9; APAF-1; Anaplastic large cell lymphoma; ALK; Apoptosis;
Characterization of alkylphenol degradation gene cluster in Pseudomonas putida MT4 and evidence of oxidation of alkylphenols and alkylcatechols with medium-length alkyl chain
Keywords: آلک; AC, alkylcatechol; AP, alkylphenol; BC, butylcatechol; BP, butylphenol; C23O, catechol 2,3-dioxygenase; IPTG, isopropyl-β-D-thiogalactoside; MM, minimal medium; NP, nonylphenol; OP, octylphenol; PH, phenol hydroxylase; THF, tetrahydrofuranalkylphenol; alk
Inhibitor-resistant type I receptors reveal specific requirements for TGF-β signaling in vivo
Keywords: آلک; Nodal; Activin; TGFβ; Xenopus; Zebrafish; ALK; Mesoderm induction; Left–right patterning
Transforming Growth Factor-β Signal Transduction in Angiogenesis and Vascular Disorders
Keywords: آلک; angiogenesis; endothelial cells; hereditary hemorrhagic telangiectasia; Smad; transforming growth factor-β; ALK; activin receptor-like kinase receptor; AVM; arteriovenous malformation; HHT; hereditary hemorrhagic telangiectasia; KO; knockout; R-Smad; rec
Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma
Keywords: آلک; Jak3; Stat3; ALK; Anaplastic large cell lymphoma;
Candida yeast long chain fatty alcohol oxidase is a c-type haemoprotein and plays an important role in long chain fatty acid metabolism
Keywords: آلک; FAO; long chain fatty alcohol oxidase; ALK; alkane; YNB; yeast nitrogen base; TE; Tris-HCl; EDTA; buffer; UTR; untranslated region; CDS; coding sequence; PCR; polymerase chain reaction; TLC; thin layer chromatography; GC-MS; gas chromatography-mass spec
Potential oncogenic action of tenascin-C in tumorigenesis
Keywords: آلک; ALK; anaplastic lymphoma kinase; Bardl; BRCA1-associated ring finger domain protein; KDdissociation constant; CASK; calmodulin-associated serine/threonine kinase; cdk; cyclin dependent kinase; CHAF1; chromatin assembly factor 1; CKI; cdk inhibitor; DKK1;