کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363508 981514 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of a novel tyrosine kinase inhibitor template
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and synthesis of a novel tyrosine kinase inhibitor template
چکیده انگلیسی

We report the design and synthesis of an insulin receptor kinase family-targeted inhibitor template using the inhibitor conformation observed in an IGF1R/inhibitor co-crystal complex by application of a novel molecular design approach that we have recently published. The synthesis of the template involves a one pot Opatz cyclization reaction that provides a versatile indole ester in good yields. We also developed the required chemistry to elaborate this template with additional substituents and have used this chemistry to prepare some initial compounds that show selective inhibition of anaplastic lymphoma kinase (ALK).

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 9, 1 May 2009, Pages 3308–3316
نویسندگان
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