Keywords: طراحی بازدارنده; Urease; Inhibitor design; Molecular modeling; Inhibitor-enzyme interactions;
مقالات ISI طراحی بازدارنده (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: طراحی بازدارنده; Malaria; Protease; Multidrug resistance; Inhibitor design; Plasmodium;
Keywords: طراحی بازدارنده; Protein-protein interaction; Computational tools; Inhibitor design; Peptidomimetic; Protein structure;
Synthesis, kinetics and inhibition of Escherichia coli Heptosyltransferase I by monosaccharide analogues of Lipid A
Keywords: طراحی بازدارنده; GT; glycosyltransferase; HepI; Heptosyltransferase I; Heptose; l-glycero-d-manno-heptose; ADP-Heptose; ADP-l-glycero-d-manno-heptose; LPS; lipopolysaccharide; ODLA; O-deacylated E. coli Kdo2-Lipid A; FDLA; fully-deacylated E. coli Kdo2-Lipid A; LPS; Lipop
Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2
Keywords: طراحی بازدارنده; PARP; Poly-ADP ribsose; Macrodomain; Inhibitor Design;
PAK4 crystal structures suggest unusual kinase conformational movements
Keywords: طراحی بازدارنده; Crystal structure; Kinase conformation; Protein structure; Inhibitor design; Gatekeeper; Back pocket;
((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies
Keywords: طراحی بازدارنده; Antibacterial resistance; Metallo-β-lactamase (MBL); VIM-2; Crystallography; Inhibitor design;
Additivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB)
Keywords: طراحی بازدارنده; SRA; sequence to reactivity algorithm; OMTKY3; turkey ovomucoid third domain; SGPA and SGPB; Streptomyces griseus protease A and B. In MEROPS database and recent literature these are listed as Streptogrisin A and B; PPE; porcine pancreatic elastase; HLE;
Virtual medicinal chemistry: In silico pre-docking functional group transformation for discovery of novel inhibitors of botulinum toxin serotype A light chain
Keywords: طراحی بازدارنده; High throughput docking; Virtual screening; Inhibitor design; Drug design; Hydroxamic acid; Botulinum neurotoxin; BoNT/A LC; Metalloproteinase; Biothreat agent; Biodefense;
Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents
Keywords: طراحی بازدارنده; CDK9 inhibitors; Inhibitor design; RNA polymerase II; Mcl-1 anti-apoptotic proteins; Anti-cancer drug discovery;
Enediol mimics as inhibitors of the d-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis
Keywords: طراحی بازدارنده; d-Arabinose 5-phosphate isomerase (A5PI); KdsD (EC 5.3.1.13); Francisella tularensis; Enediol; Inhibitor design
Design, synthesis and biological evaluation of peptidyl-vinylaminophosphonates as novel cysteine protease inhibitors
Keywords: طراحی بازدارنده; Cysteine; Protease inhibitors; Vinylaminophosphonates; Tsuji-Trost reaction; Inhibitor design; Synthesis;
Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase
Keywords: طراحی بازدارنده; Fructose-1,6-biphosphate aldolase; Giardia lamblia; Zn2+ coordination; Hydroxypyridinone; EXAFS; Inhibitor design
Computer- and structure-based lead design for epigenetic targets
Keywords: طراحی بازدارنده; Epigenetic targets; Histone modifiers; Virtual screening; Inhibitor design; Docking
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain
Keywords: طراحی بازدارنده; AMP; adenosine 5â²-monophosphate; IMP; inosine 5â²-monophosphate; IMPDH; inosine monophosphate dehydrogenase; NAD; nicotinamide adenine dinucleotide; NMN; nicotinamide mononucleotide; TR; tiazofurin; TAD; thiazole-4-carboxamide adenine dinucleotide; MPA
Structural biology of Mycobacterium tuberculosis proteins: The Indian efforts
Keywords: طراحی بازدارنده; Structural genomics; X-ray crystallography; NMR; Inhibitor design;
Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)
Keywords: طراحی بازدارنده; MIF; Inhibitor design; Protein–protein interactions; Cytokine; Inflammatory disease
Spectroscopic and structural analysis of somatic and N-domain angiotensin I-converting enzyme isoforms from mesangial cells from Wistar and spontaneously hypertensive rats
Keywords: طراحی بازدارنده; Angiotensin I-converting enzyme; N-domain ACE isoforms; Structure analysis; Circular dichroism; Hypertension; Inhibitor design
Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines
Keywords: طراحی بازدارنده; Inhibitor design; Synthesis; Imidazo[1,2-a]pyrazine; Anticancer activity; Structure activity relationship
Inhibitors to understand molecular mechanisms of NAD+-dependent deacetylases (sirtuins)
Keywords: طراحی بازدارنده; Histone deacetylases; Sirtuins; Inhibitor design
Kinetic analysis of site-directed mutants of methionine synthase from Candida albicans
Keywords: طراحی بازدارنده; Methionine synthase; Cobalamin independent; Site-directed mutagenesis; Candida albicans; Molecular model; Fusion protein; Active site mapping; Inhibitor design
Human sialidase inhibitors: Design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids
Keywords: طراحی بازدارنده; Sialidase; De novo design; Virtual screening; Inhibitor design; Fluoro benzoic acid; Ludi/CAP; Docking
Design and synthesis of a novel tyrosine kinase inhibitor template
Keywords: طراحی بازدارنده; Anaplastic lymphoma kinase; ALK; De novo ligand design; Kinase template synthesis; Insulin receptor kinase family; Inhibitor design
Induced-fit docking studies of the active and inactive states of protein tyrosine kinases
Keywords: طراحی بازدارنده; Protein kinase; Imatinib; Erlotinib; Inhibitor design; Loop movement
Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: Selective inhibitors of lysosomal sialidase (NEU1)
Keywords: طراحی بازدارنده; Sialidase; Inhibitor design; DANA; Selectivity; Homology models; Docking
Synthetic active site-directed inhibitors of metzincins: Achievement and perspectives
Keywords: طراحی بازدارنده; MMPs; Matrix metalloproteinase; Zinc protease; Inhibitor; Hydroxamate; Phosphinic peptide; Inhibitor design; ADAM; ADAMTS
Docking-based 3D-QSAR study for 11β-HSD1 inhibitors
Keywords: طراحی بازدارنده; 11β-HSD1; 3D-QSAR; Docking; Inhibitor design
Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors
Keywords: طراحی بازدارنده; Oligoamines; Aspartic protease inhibitors; HIV-1 protease; Inhibitor design
The Molecular Structure of Epoxide Hydrolase B from Mycobacterium tuberculosis and Its Complex with a Urea-Based Inhibitor
Keywords: طراحی بازدارنده; Mtb, Mycobacterium tuberculosis; EH, epoxide hydrolase; TB, tuberculosis; Mtm, Mycobacterium marinum; LEH, limonene EH; sEH, soluble EHMycobacterium tuberculosis; epoxide hydrolase; hydrolase fold; enzyme mechanism; inhibitor design
A minimalistic approach to identify substrate binding features in B1 Metallo-β-lactamases
Keywords: طراحی بازدارنده; Metallo-β-lactamases; Inhibitor design; Ligand binding; Monocyclic β-lactams
Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity
Keywords: طراحی بازدارنده; Parainfluenza virus; Sialidase; Sialic acids; Inhibition; Computational chemistry; Inhibitor design; Carbohydrates
Molecular insights of SAH enzyme catalysis and implication for inhibitor design
Keywords: طراحی بازدارنده; S-adenosylhomocysteine hydrolase (SAH); Docking; Enzyme catalysis; Inhibitor design
Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring
Keywords: طراحی بازدارنده; HIV-1; Integrase; Quinoline derivatives; Biological activity; Inhibitor design
NADP+ Expels both the Co-factor and a Substrate Analog from the Mycobacterium tuberculosis ThyX Active Site: Opportunities for Anti-bacterial Drug Design
Keywords: طراحی بازدارنده; thymidylate synthase; flavin; inhibitor design; bivalent drugs
Homology modeling of the DNA-binding domain of human Smad5: A molecular model for inhibitor design
Keywords: طراحی بازدارنده; Homology modeling; Smads; Transforming growth factor-beta; Phylogenetic analysis; Inhibitor design
Combinatorial design of nonsymmetrical cyclic urea inhibitors of aspartic protease of HIV-1
Keywords: طراحی بازدارنده; Inhibitor design; Aspartic protease of HIV-1; Library of nonsymmetrical cyclic ureas; Structure-based focusing; In silico screening; ADME properties