Design, synthesis and biological evaluation of peptidyl-vinylaminophosphonates as novel cysteine protease inhibitors

Peptidyl-vinylaminophosphonates, a new class of cysteine protease inhibitors have been designed and sythesized. Some of the synthesized molecules have shown inhibition against papain, a model cysteine protease with IC50 values in the range of 30-54 μM.